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ASH 2018: ECOG trial shows superiority of Ibrutinib and rituximab over FCR
Stilgenbauer discusses the practice changing significance of this study that proved that ibrutinib and
rituximab
was superior to FCR for both overall and progression free survival for frontline patients <70 years old..
Stilgenbauer discusses the practice changing significance of this study that proved that ibrutinib and
rituximab
was superior to FCR for both overall and progression free survival for frontline patients <70 years old..
bkoffman
CLL CURE Hero
in
CLL Support
5 years ago
New to this community - CLL diagnosis Feb 2018
I was diagnosed with CLL in February 2018, following a period of feeling very tired, low Hb, shortness of breath and night sweats. After numerous blood tests, CT scan, gastroscopy and colonoscopy (to rule out any bleeding) I was given my diagnosis and told that I needed chemo treatment, due to symptoms
I was diagnosed with CLL in February 2018, following a period of feeling very tired, low Hb, shortness of breath and night sweats. After numerous blood tests, CT scan, gastroscopy and colonoscopy (to rule out any bleeding) I was given my diagnosis and told that I needed chemo treatment, due to symptoms
Kingfisher20
in
CLL Support
5 years ago
11q deletion, my experience and short story
I just finished reading a post concerning an 11q deletion being mutated or not. I have the 11q deletion, and have had it since first diagnosed in 2009 at age 60. 11q was not a big deal back then, as not as much was known about it 10 years ago. 17p was always the bad marker, and I always dreaded that
I just finished reading a post concerning an 11q deletion being mutated or not. I have the 11q deletion, and have had it since first diagnosed in 2009 at age 60. 11q was not a big deal back then, as not as much was known about it 10 years ago. 17p was always the bad marker, and I always dreaded that
steve5441
in
CLL Support
5 years ago
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splenic marginal zone lymphoma treatments
Does anyone know of the next line of treatment if
rituximab
and ibrutinib has not worked? Is there something that can be taken for an elderly person? And I have seen some posts about tongue ulcers and ibrutinib; is this a common problem and what is best to treat?
Does anyone know of the next line of treatment if
rituximab
and ibrutinib has not worked? Is there something that can be taken for an elderly person? And I have seen some posts about tongue ulcers and ibrutinib; is this a common problem and what is best to treat?
lukidude
in
Non Hodgkin's Lymphoma Friends
5 years ago
Rituximab
Finally after complete 4werk course of
Rituximab
we are seeing gradual improvement. It is been four weeks since his last treatment Monday He received a count of 84,000. Unfortunately he is also experiencing a drop in his IgG.
Finally after complete 4werk course of
Rituximab
we are seeing gradual improvement. It is been four weeks since his last treatment Monday He received a count of 84,000. Unfortunately he is also experiencing a drop in his IgG.
Mythreeboys
in
ITP Support Association
5 years ago
Ibrutinib Partial Response
I have been on Ibrutinib a little over a year now Male currently 49 yrs. old my WBC count was as high as 350k now hovering at 85k. I am now on my second oncologist first one was adamant about FCR which I refused since I wanted a chemo free treatement. I have read so much about the new combination Venetoclax
I have been on Ibrutinib a little over a year now Male currently 49 yrs. old my WBC count was as high as 350k now hovering at 85k. I am now on my second oncologist first one was adamant about FCR which I refused since I wanted a chemo free treatement. I have read so much about the new combination Venetoclax
Litevibe
in
CLL Support
5 years ago
What do all these Acronyms mean?
Is there a post that explains all these acronyms you all seem to know? I am having trouble understanding many of the posts because I have no idea what they mean. I am new to this forum and it all sounds like alphabet soup to me. What is ALC ? IhGV? FRC or is it FCR? Clearly there is a lot to learn, but
Is there a post that explains all these acronyms you all seem to know? I am having trouble understanding many of the posts because I have no idea what they mean. I am new to this forum and it all sounds like alphabet soup to me. What is ALC ? IhGV? FRC or is it FCR? Clearly there is a lot to learn, but
t2aa
in
CLL Support
5 years ago
Worried mum
Hi I am fairly new hear and haven’t posted before. But I have read many posts and been really greatful to be amongst people who get it. My daughter has been unwell and has low platelets. I have been told that CLL can be “slightly “ hereditary- and to be honest even the thought of my child going through
Hi I am fairly new hear and haven’t posted before. But I have read many posts and been really greatful to be amongst people who get it. My daughter has been unwell and has low platelets. I have been told that CLL can be “slightly “ hereditary- and to be honest even the thought of my child going through
Lexi1205
in
CLL Support
5 years ago
What is a non chemotherapy treatment regimen to treat CLl
I have just had my regular 6 week visit to my oncologist/haematologist .My readings have jumped after being stable since last November. ALC 84. Has been at 69 since last April. Dx 2016 Alc 21 has gradually increased . However my eGFR has dropped to 44 reference no is > 59. Creatinine is 139.above the
I have just had my regular 6 week visit to my oncologist/haematologist .My readings have jumped after being stable since last November. ALC 84. Has been at 69 since last April. Dx 2016 Alc 21 has gradually increased . However my eGFR has dropped to 44 reference no is > 59. Creatinine is 139.above the
Joffre1
in
CLL Support
5 years ago
restless legs
Consultant said it was the chemo - Bendamustine and
Rituximab
. Can I do anything about it?[i] I 'm going for a lie down xx[/i]
Consultant said it was the chemo - Bendamustine and
Rituximab
. Can I do anything about it?[i] I 'm going for a lie down xx[/i]
snowdroprose
in
CLL Support
5 years ago
Solve the problems
Rituximab
.. chemotherapeutic treatments ! So far two ! The reason why am doing this is I'm just wondering why this is happening started looking online and seeing different things so I want to put my story out there !!!
Rituximab
.. chemotherapeutic treatments ! So far two ! The reason why am doing this is I'm just wondering why this is happening started looking online and seeing different things so I want to put my story out there !!!
Blue5151
in
Scleroderma & Raynaud's UK (SRUK)
5 years ago
I'm on Rituximab and wondering if it is safe to be around people that have been given live jabs?
just be for cancer patients on
rituximab
.
just be for cancer patients on
rituximab
.
mille
in
NRAS
5 years ago
Prof Fegan talks from ASH 2018 | Telomere length can predict the outcome of FCR chemoimmunotherapy in CLL
Here, Christopher Fegan, MB, MD, FRCP, FRCPath, of Cardiff University, Cardiff, UK, introduces telomere length as a key determinant of telomere function, before presenting exciting data that suggests telomere length is a powerful predictor of outcome following fludarabine, cyclophosphamide and
rituximab
Here, Christopher Fegan, MB, MD, FRCP, FRCPath, of Cardiff University, Cardiff, UK, introduces telomere length as a key determinant of telomere function, before presenting exciting data that suggests telomere length is a powerful predictor of outcome following fludarabine, cyclophosphamide and
rituximab
HAIRBEAR_UK
Administrator
in
Leukaemia CARE
5 years ago
What causes ITP..?
One more week to go and then my latest
Rituximab
treatment will be over and then fingers crossed those platelets increase and stabilize :) Regards, Martin.
One more week to go and then my latest
Rituximab
treatment will be over and then fingers crossed those platelets increase and stabilize :) Regards, Martin.
Johnsonmartinp
in
ITP Support Association
5 years ago
Immunotherapy
This article from the Mayo Clinic talks about monoclonal antibody treatment (for example
Rituximab
/Rituxan) https://tinyurl.com/y7uyutp7
This article from the Mayo Clinic talks about monoclonal antibody treatment (for example
Rituximab
/Rituxan) https://tinyurl.com/y7uyutp7
Shar0n
Volunteer
in
Non Hodgkin's Lymphoma Friends
5 years ago
Anyone had these drugs? Comments please.
My Hem/Onc is prescribing Bendamustine and
Rituximab
as first line treatment. Dr said there is a protocol for 65 and under and one for 70 and older. I’m 68 so being closer to 70 that will be my course. (I believe dosage is lower). 2 days once a month for 6 months I’m in Alberta Canada.
My Hem/Onc is prescribing Bendamustine and
Rituximab
as first line treatment. Dr said there is a protocol for 65 and under and one for 70 and older. I’m 68 so being closer to 70 that will be my course. (I believe dosage is lower). 2 days once a month for 6 months I’m in Alberta Canada.
Estate1
in
CLL Support
5 years ago
Chemo-Free Treatment Best Option for CLL Patients Under 70
Results of the phase III ECOG trial found that the combination of ibrutinib (Imbruvica) plus
rituximab
(Rituxan) came out superior to the chemotherapy and immunotherapy (chemoimmunotherapy) grouping of fludarabine, cyclophosphamide, and
rituximab
, known as FCR.
Results of the phase III ECOG trial found that the combination of ibrutinib (Imbruvica) plus
rituximab
(Rituxan) came out superior to the chemotherapy and immunotherapy (chemoimmunotherapy) grouping of fludarabine, cyclophosphamide, and
rituximab
, known as FCR.
GlennSabin
in
CLL Support
5 years ago
Chemo-Free Treatment Best Option for CLL Patients Under 70
Results of the phase III ECOG trial found that the combination of ibrutinib (Imbruvica) plus
rituximab
(Rituxan) came out superior to the chemotherapy and immunotherapy (chemoimmunotherapy) grouping of fludarabine, cyclophosphamide, and
rituximab
, known as FCR.
Results of the phase III ECOG trial found that the combination of ibrutinib (Imbruvica) plus
rituximab
(Rituxan) came out superior to the chemotherapy and immunotherapy (chemoimmunotherapy) grouping of fludarabine, cyclophosphamide, and
rituximab
, known as FCR.
GlennSabin
in
CLL America Support
5 years ago
FYI/Trial data to be discussed this weekend
In CLL, there are multiple trials of interest being presented with the potential to have an impact on practice, including the phase III Alliance North American Intergroup Study A041202 exploring ibrutinib alone or in combination with
rituximab
vs standard chemoimmunotherapy with bendamustine plus
rituximab
In CLL, there are multiple trials of interest being presented with the potential to have an impact on practice, including the phase III Alliance North American Intergroup Study A041202 exploring ibrutinib alone or in combination with
rituximab
vs standard chemoimmunotherapy with bendamustine plus
rituximab
Newchallnge
in
CLL Support
5 years ago
Question - how many different varieties of antibodies can B-cells make? Hint - it's hypermutation (IGHV mutation) that makes it possible
Answer, 1 quintillion or 1,000,000,000,000,000,000 or 10^18 according to[i] a team led by Drs. Bryan Briney and Dennis R. Burton at Scripps Research examined antibody-producing B cells isolated from blood samples of 10 people between the ages of 18 and 30. ... Additional studies are needed to more accurately
Answer, 1 quintillion or 1,000,000,000,000,000,000 or 10^18 according to[i] a team led by Drs. Bryan Briney and Dennis R. Burton at Scripps Research examined antibody-producing B cells isolated from blood samples of 10 people between the ages of 18 and 30. ... Additional studies are needed to more accurately
AussieNeil
Administrator
in
CLL Support
5 years ago
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