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Loxo305 trial
I looked at it but apparently there are several phases, this is the one we are looking at: BRUIN CLL-322: a Phase 3 open-label, randomized study of fixed duration pirtobrutinib (LOXO-305) plus venetoclax and
rituximab
versus venetoclax and
rituximab
in previously treated Chronic Lymphocytic Leukemia
I looked at it but apparently there are several phases, this is the one we are looking at: BRUIN CLL-322: a Phase 3 open-label, randomized study of fixed duration pirtobrutinib (LOXO-305) plus venetoclax and
rituximab
versus venetoclax and
rituximab
in previously treated Chronic Lymphocytic Leukemia
Alex830
in
CLL Support
2 years ago
mild struggles
hi. It’s been seven years since I was on this site. Diagnosed 2007. FCR. Then again in 2012. Various treatments. 2014 ibrutinib. 2016 Venetoclax and obinutuzumab on trial. It worked. 2021 CLL back in bone marrow. Now starting to grow slowly. Haemaglobin only 13. I like more. I’m 54.
hi. It’s been seven years since I was on this site. Diagnosed 2007. FCR. Then again in 2012. Various treatments. 2014 ibrutinib. 2016 Venetoclax and obinutuzumab on trial. It worked. 2021 CLL back in bone marrow. Now starting to grow slowly. Haemaglobin only 13. I like more. I’m 54.
Corin850
in
CLL Support
9 months ago
None bleeds
Has anyone on
Rituximab
and methotrexate experienced nose bleeds I'm trying to figure out if its related to the meds.
Has anyone on
Rituximab
and methotrexate experienced nose bleeds I'm trying to figure out if its related to the meds.
Youelbeverly
in
NRAS
2 years ago
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TSH suddenly elevated.
Any thoughts regarding
rituximab
and TSH? Or could this be linked to me having been unwell? Any thoughts gratefully received. I am dairy, gluten and soya free in my diet and I have removed chemicals from my lifestyle wherever possible.
Any thoughts regarding
rituximab
and TSH? Or could this be linked to me having been unwell? Any thoughts gratefully received. I am dairy, gluten and soya free in my diet and I have removed chemicals from my lifestyle wherever possible.
ZoMa
in
Thyroid UK
1 year ago
What’s next?
I was diagnosed, in December of 2018, with CLL and placed on W&W. Less than a year later I started FCR. After completing FCR my blood counts rose steadily until I reached stage 4 which led to two years of Venclexta (400mg daily) treatments. Throughout all treatments I’ve had monthly bloodwork, yearly
I was diagnosed, in December of 2018, with CLL and placed on W&W. Less than a year later I started FCR. After completing FCR my blood counts rose steadily until I reached stage 4 which led to two years of Venclexta (400mg daily) treatments. Throughout all treatments I’ve had monthly bloodwork, yearly
Pokerguy
in
CLL Support
10 months ago
Rituximab for Rheumatoid Vasculitis
I had an infusion of
Rituximab
on June 2022 and have felt no improvement whatsoever. All my illnesses remain as bad as ever. Anyone else have Rheumatoid Vasculitis and had RTX and have noticed improvement. Thanks
I had an infusion of
Rituximab
on June 2022 and have felt no improvement whatsoever. All my illnesses remain as bad as ever. Anyone else have Rheumatoid Vasculitis and had RTX and have noticed improvement. Thanks
sunshineday
in
Vasculitis UK
2 years ago
acalabrutinib and tegretol
Hi everyone My 70-year-old father had FCR five years ago, with great results. We’ve just been advised he needs to start treatment again, and they’ve chosen Acalabrutinib. He has been advised he had to go off his medication for epilepsy, which is Tegretol. We’re obviously not thrilled about it but
Hi everyone My 70-year-old father had FCR five years ago, with great results. We’ve just been advised he needs to start treatment again, and they’ve chosen Acalabrutinib. He has been advised he had to go off his medication for epilepsy, which is Tegretol. We’re obviously not thrilled about it but
MelaniePet
in
CLL Support
11 months ago
stomach
The only thing to have helped is when I have an infusion of
rituximab
. Unfortunately it does not last the six months . Most days I can eat a biscuit or part of a yogurt . I build up gradually over a couple of days , until the pain starts again . Then no more food for a couple of days .
The only thing to have helped is when I have an infusion of
rituximab
. Unfortunately it does not last the six months . Most days I can eat a biscuit or part of a yogurt . I build up gradually over a couple of days , until the pain starts again . Then no more food for a couple of days .
artists
in
Vasculitis UK
2 years ago
Life after Rituximab? What is the next chapter?
Diagnose with GPA in December 2019 and after the usual cocktail of Steroids Cyclophosphamide and an unsuccessful spell with Azathioprine I now approach my next infusion of
Rituximab
in a couple of weeks. My Consultant is saying because my ANCA marker is so low this should be my last one.
Diagnose with GPA in December 2019 and after the usual cocktail of Steroids Cyclophosphamide and an unsuccessful spell with Azathioprine I now approach my next infusion of
Rituximab
in a couple of weeks. My Consultant is saying because my ANCA marker is so low this should be my last one.
Investigator1
in
Vasculitis UK
2 years ago
rituximab and filgotinib
anyone any experience with either of these two drugs please? I’m on tocilizumab but it’s effectiveness is waning and I’ve been offered these as an alternative. I have anti-ccp positive RA, Fibromyalgia and osteoporosis. Diagnosed in 2003.
anyone any experience with either of these two drugs please? I’m on tocilizumab but it’s effectiveness is waning and I’ve been offered these as an alternative. I have anti-ccp positive RA, Fibromyalgia and osteoporosis. Diagnosed in 2003.
tamnwill
in
NRAS
1 year ago
Windermere
I had FCR in 2012 was in remission until 2018. Then started ibrutinib and still on it, how long is it likely to keep me in remission.
I had FCR in 2012 was in remission until 2018. Then started ibrutinib and still on it, how long is it likely to keep me in remission.
Windemere
in
CLL Support
11 months ago
Systemic sclerosis
I would like to know about health system in the UK and the
rituximab
and iloprost.
I would like to know about health system in the UK and the
rituximab
and iloprost.
Lo1234
in
Scleroderma & Raynaud's UK (SRUK)
2 years ago
Covid without Rituximab - Any Similar Experiences
I was at the Hospital today having my 3 monthly bloods in prep for my
Rituximab
in November.
I was at the Hospital today having my 3 monthly bloods in prep for my
Rituximab
in November.
Investigator1
in
Vasculitis UK
2 years ago
This one is a bit "left field" but here goes...
"Can any one hear me", says the Robin? OK! Infatuation with Robins aside... After my spectacular successful knee replacement I decide to buy myself a new mountain bike. BUT... bear with me... I have been 5yrs remission since FCR, Lymphocyte count 0.7 so on prophylactic Aciclovir (against Herpes infection
"Can any one hear me", says the Robin? OK! Infatuation with Robins aside... After my spectacular successful knee replacement I decide to buy myself a new mountain bike. BUT... bear with me... I have been 5yrs remission since FCR, Lymphocyte count 0.7 so on prophylactic Aciclovir (against Herpes infection
JigFettler
Volunteer
in
CLL Support
11 months ago
All good things must come to an end
He presented 2 options with one being venetoclax along with
rituximab
( 6 mnths) and the other a clinical trial which he believes I would be perfect for because other than CLL I am in good health. I have been on Ibrutinib for almost 5 years now with great results.
He presented 2 options with one being venetoclax along with
rituximab
( 6 mnths) and the other a clinical trial which he believes I would be perfect for because other than CLL I am in good health. I have been on Ibrutinib for almost 5 years now with great results.
rcusher
in
CLL Support
2 years ago
Evusheld availability in UK
I have GPA vasculitis but now in remission on 6 monthly
rituximab
and off prednisolone for 9 months. I continue to shield and shop online but do eat out in pub gardens in the summer. I am due the 24-month dose of
rituximab
in November 2022.
I have GPA vasculitis but now in remission on 6 monthly
rituximab
and off prednisolone for 9 months. I continue to shield and shop online but do eat out in pub gardens in the summer. I am due the 24-month dose of
rituximab
in November 2022.
RichardGPA65yrs
in
Vasculitis UK
2 years ago
Being Positive and Supportive
As I read all the kind responses to my post about finally feeling better I realize the best way to support this group and the best medicine for me and my family is to be positive, hopeful and upbeat. During the FCR treatment in 2018 I was just that! Then after 11 skin cancer surgeries, Covid, and many
As I read all the kind responses to my post about finally feeling better I realize the best way to support this group and the best medicine for me and my family is to be positive, hopeful and upbeat. During the FCR treatment in 2018 I was just that! Then after 11 skin cancer surgeries, Covid, and many
skipro
in
CLL Support
1 year ago
CT thorax results: borderline lymphs
Hi everyone, My father has CLL/SLL from 2018 and had his first treatment at 2019 with Bendamustine and
Rituximab
because of very enlarged lymph nodes. After his treatment the lymph nodes decreaded to the original size.
Hi everyone, My father has CLL/SLL from 2018 and had his first treatment at 2019 with Bendamustine and
Rituximab
because of very enlarged lymph nodes. After his treatment the lymph nodes decreaded to the original size.
TOFK
in
CLL Support
2 years ago
Rituximab and Flu Vaccination
Hi, I am due my next
Rituximab
infusion tomorrow. I was wondering how long after infusion do I have to wait before taking Flu Vaccination ? Many thanks, Marian
Hi, I am due my next
Rituximab
infusion tomorrow. I was wondering how long after infusion do I have to wait before taking Flu Vaccination ? Many thanks, Marian
Haired
in
LUPUS UK
2 years ago
MRD blood test after Venetoclax treatment
I finished Venetoclax treatment last year in the uk. My haematologist is awaiting the result of a MRD blood test and if negative then he tells me I will be discharged. Bit of a surprise to me as I was diagnosed in 2004 and have been routinely monitored since then. I had FCR treatment in 2014. My blood
I finished Venetoclax treatment last year in the uk. My haematologist is awaiting the result of a MRD blood test and if negative then he tells me I will be discharged. Bit of a surprise to me as I was diagnosed in 2004 and have been routinely monitored since then. I had FCR treatment in 2014. My blood
yorkie19
in
CLL Support
1 year ago
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