Experiences with

Olaparib

Hi there, I’ve been on Olaparib for three weeks now and so far have only experienced mild nausea. However, I do have a very watery mouth some days which is quite unpleasant. Does anyone else have this side effect and is there anything that helps alleviate it? Denise

I have just started on olaparib- 16 capsules a day which amounts to 800mg. I was just wondering if those who have been prescribed this are on tablets or capsules and if so why the difference. It is hard to swallow that amount daily. Rosie

After that, went to Olaparib (Lynparza) took care of liver mets but not PSA, so added Zytiga, and that worked very well for over 1-1/2 years - until last summer. MO took him off the Lynparza, and switched the steroid from prednisone to dexamethasone to get more time on Zytiga..

Hello All This is to let you know NICE have announced today that olaparib will be available as second line maintenance treatment via the Cancer Drugs Fund, for those with the BRCA mutation.

Hi everyone, My dad is doing well at the beginning of his treatment (on a Zytiga and a double-blind trail of olaparib). His PSA numbers dropped quick and he is feeling great. He wants to go on vacation but won't go without travel insurance.

Hello All The National Centre for Pharmacoeconomics has completed a rapid review of olaparib for the treatment of ovarian cancer, as maintenance treatment following first line platinum-based chemotherapy .

FINDINGS 711 patients consented for targeted screening between April 1, 2015, and Aug 30, 2018. 161 patients had DDR gene aberrations, 98 of whom were randomly assigned and treated (49 patients for each olaparib dose), with 92 evaluable for the primary endpoint (46 patients for each olaparib dose)

There is more information on the SMC website here: https://www.scottishmedicines.org.uk/media/4953/decision-explained-olaparib-lynparza.pdf Best wishes Anna Ovacome Support

Now on Olaparib off Xtandi ...psa rose to 4.8. But, met in C5 C6 area is really painful. Pain in my neck, left shoulder, arm and fingers are tingly. Very limited motion now in my left arm. CT scan showed narrowing ... thanks to my wonderful PCa onologist, I got into a neurosurgeon right away.

Doctor suggested to use OLAPARIB as gene test came positive. Anyone here used it or using it ? How effective is it ? We are from India. It's very costly here. Anyone know the way to get it in less price ?

I hope this interview is attainable. https://www.practiceupdate.com/expertopinion/4329/67/11?elsca1=emc_enews_weekinreview&elsca2=email&elsca3=practiceupdate_advancedprostatecancer&elsca4=advancedprostatecancer&elsca5=newsletter&rid=MzQwNTM3NTczMjUxS0&lid=10332481

So they started me on Olaparib and scheduled the lumpectomy which I did in August 2019 back on Olaparib tough issues with fatigue reflux and constipation which they said would settle. And it has thank god. I’m on the strongest dose 8 capsule twice a day.

Your comments would be used to inform two NICE submissions, one about making olaparib plus bevacizumab available first line (which was studied on the PAOLA trial) and one about making niraparib available first line (which was studied on the PRIMA trial).

Consult at Johns Hopkins offered Pembro and Olaparib combo clinical trial . I did not have BRCA1/2 or ATM gene mutations and not sure of efficacy of this trial for me. Have read of adverse effects of those on trial. Weighing pros/cons.

inhibitor-based combination regimens have shown activity in mCRPC, including the CheckMate 650 trial of nivolumab (Opdivo) plus the CTLA-4 checkpoint inhibitor ipilimumab (Yervoy) and KEYNOTE-365, which showed promising antitumor activity and well-tolerated TRAEs when pembrolizumab was combined with olaparib

This is because the Scottish Medicines Consortium (SMC) will be making their announcement in the next few weeks about olaparib availability.

Anyone on olaparib and the coc protocol?? Advice needed??

When I was diagnosed Avastin was THE maintenance drug.Due to research many more maintenance drugs have been licensed,especially Parp inhibitors.Ive been on Parp (Olaparib ) since Jan 2016.

disease with two to three cycles of Lu177 therapy followed by ADT and Docetaxel chemo: https://up.picr.de/37234873ob.png The PRINCE trial is combining the Lu177 therapy with Immunotherapy (Pembroluzimab): https://up.picr.de/37234878hz.png Then there is the LuPARP trial combining Lu177 therapy with Olaparib

MO offered us a trial of olaparib in combination with AZD6738 . Husband did not have braca or any other gene mutations show up on DNA testing so I asked why we would go on this. He said "if it works, it will help bone mets" .