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ARASENS Darolutamide vs Placebo
This Kaplan-Meier plot show the Castration - Resistant Prostate Cancer Free survival probability (%) for two groups: (A)
Darolutamide
+ ADT + Docetaxel, versus (B)
Placebo
+ ADT + Docetaxel, taken at two different times: 2 years and 4 years. There is a very large increase in survival
This Kaplan-Meier plot show the Castration - Resistant Prostate Cancer Free survival probability (%) for two groups: (A)
Darolutamide
+ ADT + Docetaxel, versus (B)
Placebo
+ ADT + Docetaxel, taken at two different times: 2 years and 4 years. There is a very large increase in survival
janebob99
in
Advanced Prostate Cancer
4 months ago
ARASENS TRIAL: Darolutamide
This Kaplan-Mieir plot show the Castration - Resistant Prostate Cancer Free survival probability (%) vs time for two groups: (A) Darolutamide + ADT + Docetaxel, versus (B) Placebo + ADT + Docetaxel. There is a very large increase in survival probability with the Darolutamide group (A) vs Placebo group
This Kaplan-Mieir plot show the Castration - Resistant Prostate Cancer Free survival probability (%) vs time for two groups: (A) Darolutamide + ADT + Docetaxel, versus (B) Placebo + ADT + Docetaxel. There is a very large increase in survival probability with the Darolutamide group (A) vs Placebo group
janebob99
in
Advanced Prostate Cancer
4 months ago
ADT with radiation?
I have a G 4+3, considered to be unfavorable intermediate risk, but a Decipher score of .4, considered to be low risk. I have opted to have radiation to treat my PCa. Do I need to take ADT with the radiation therapy? My MO suggested 4 to 6 months of Orgavix (not sure if I'm spelling it correctly). If
I have a G 4+3, considered to be unfavorable intermediate risk, but a Decipher score of .4, considered to be low risk. I have opted to have radiation to treat my PCa. Do I need to take ADT with the radiation therapy? My MO suggested 4 to 6 months of Orgavix (not sure if I'm spelling it correctly). If
CBRD
in
Advanced Prostate Cancer
4 months ago
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After 16 days into a 1/8gr NDT increase im starting to feel worse (did feel better for it) is this T4 kicking in or its converted T3 ?
Hi All, I was feeling better for 2 weeks on an 1/8 gr NDT increase from 1 1/4gr pr dy to 1 3/8gr pr dy. Day 16 and im starting to sweat at night, feel jittery inside which wears off 7 hours after meds. Would this be the additional T4 thats effecting me or the additional T3 thats coverted from the
Hi All, I was feeling better for 2 weeks on an 1/8 gr NDT increase from 1 1/4gr pr dy to 1 3/8gr pr dy. Day 16 and im starting to sweat at night, feel jittery inside which wears off 7 hours after meds. Would this be the additional T4 thats effecting me or the additional T3 thats coverted from the
Gillybean1
in
Thyroid UK
4 months ago
life Insurance
I wanted to get opinions regarding my life insurance 800K which will be expiring in a couple of months. I have the option to roll it over to a universal policy but it’s going to cost me 2K a month. I’m still Homone sensitive. And been on ADT and Nubeqa (daroludimide) for the last couple of years. Had
I wanted to get opinions regarding my life insurance 800K which will be expiring in a couple of months. I have the option to roll it over to a universal policy but it’s going to cost me 2K a month. I’m still Homone sensitive. And been on ADT and Nubeqa (daroludimide) for the last couple of years. Had
JDKotter
in
Advanced Prostate Cancer
4 months ago
ISO a third MO opinion for my dad
Hi all! My dad was diagnosed with pca in 2021, prostate removal that summer. After radical - was told no treatment necessary and lo and behold January the following year psa went from .04 to 1.2 in 3 months. Put on adt and zytiga (not sure of spelling), scans show pelvic bed spots and 1 on s1, radiation
Hi all! My dad was diagnosed with pca in 2021, prostate removal that summer. After radical - was told no treatment necessary and lo and behold January the following year psa went from .04 to 1.2 in 3 months. Put on adt and zytiga (not sure of spelling), scans show pelvic bed spots and 1 on s1, radiation
Dsmejkal88
in
Advanced Prostate Cancer
4 months ago
Dr Dipnarine Maharaj Immune Regenerative Medicine in Boynton Beach FL
Has anyone heard of him? I am about to start ADT and salvage radiation in 2 months (PSA 0.052) . So in mean time I was going to check him out and wondered if anyone who does a ton of research has heard of him?
Has anyone heard of him? I am about to start ADT and salvage radiation in 2 months (PSA 0.052) . So in mean time I was going to check him out and wondered if anyone who does a ton of research has heard of him?
Peppertree602
in
Advanced Prostate Cancer
4 months ago
New 2024 AUA/ASTRO/SUO Guidelines for Salvage Therapy
https://www.auanet.org/guidelines-and-quality/guidelines/salvage-therapy-for-prostate-cancer Not surprising. I think they should recommend adjuvant ADT at a PSA≥0.35 instead of ≥0.7 because I think patients are hoping for curative SRT and not just equivalent survival. https://www.prostatecancer.news
https://www.auanet.org/guidelines-and-quality/guidelines/salvage-therapy-for-prostate-cancer Not surprising. I think they should recommend adjuvant ADT at a PSA≥0.35 instead of ≥0.7 because I think patients are hoping for curative SRT and not just equivalent survival. https://www.prostatecancer.news
Tall_Allen
in
Advanced Prostate Cancer
4 months ago
PSA doubled in last 30 days after 4 months stable since Provenge. What's next?
Update: PSA remained roughly 1.7 to 1.8 for last 4 months after Provenge but yesterday's 30-day PSA test revealed a jump to 3.190 so something is growing quick. I have been off of all ADT since finishing fourth LU-177 injection five months ago and one SBRT treatment 4 months ago. After LU-177, PSA
Update: PSA remained roughly 1.7 to 1.8 for last 4 months after Provenge but yesterday's 30-day PSA test revealed a jump to 3.190 so something is growing quick. I have been off of all ADT since finishing fourth LU-177 injection five months ago and one SBRT treatment 4 months ago. After LU-177, PSA
SViking
in
Advanced Prostate Cancer
4 months ago
my first post
Hello there, I’ve been dealing with this since 1/2015. I’ve had brachytherapy, chemotherapy, hormone therapy, cyber knife, immunotherapy, more chemotherapy, now taking Everolimus and letrozole. I’ve always felt that this was a chronic disease after the medications stopped working onto the next regimen
Hello there, I’ve been dealing with this since 1/2015. I’ve had brachytherapy, chemotherapy, hormone therapy, cyber knife, immunotherapy, more chemotherapy, now taking Everolimus and letrozole. I’ve always felt that this was a chronic disease after the medications stopped working onto the next regimen
Sabrina02
in
SHARE Uterine Cancer Support
4 months ago
PSA vs Testosterone Nadir for CRPC and Non-CRPC
This plot from Safriadi (2022) compares the mean values of PSA nadir versus Testosterone Nadir comparing Non-Castrate Resistant PC (Non-CRPC) to Castrate-Resistant PC (CRPC) men. For Non-CRPC men, the range of T-nadir was 2.5-49 ng/dL (mean = 21) and range for PSA nadir was 0.02-9 ng/mL (mean=2). For
This plot from Safriadi (2022) compares the mean values of PSA nadir versus Testosterone Nadir comparing Non-Castrate Resistant PC (Non-CRPC) to Castrate-Resistant PC (CRPC) men. For Non-CRPC men, the range of T-nadir was 2.5-49 ng/dL (mean = 21) and range for PSA nadir was 0.02-9 ng/mL (mean=2). For
janebob99
in
Advanced Prostate Cancer
4 months ago
Rising PSA post RP,IRT,ADT
Have 2 consecutive rising PSA - .04,.05,.1. Year post RP,IRT,ADT.. understand if goes to .2 new scans and possible Radiation. I surely don't like the ADT.. Any thoghts
Have 2 consecutive rising PSA - .04,.05,.1. Year post RP,IRT,ADT.. understand if goes to .2 new scans and possible Radiation. I surely don't like the ADT.. Any thoghts
ChristopherH
in
Advanced Prostate Cancer
4 months ago
results from Blue Horizon
please find attached my recent blood results from blue horizon. They have commented that my TSH is too low and I should consider reducing my NDT. As I feel well atm I would be grateful for some opinions on this as my Free T3 though high in range isn’t over. My Ferritin is always high but my GP seems
please find attached my recent blood results from blue horizon. They have commented that my TSH is too low and I should consider reducing my NDT. As I feel well atm I would be grateful for some opinions on this as my Free T3 though high in range isn’t over. My Ferritin is always high but my GP seems
Mandcol
in
Thyroid UK
4 months ago
At the crossroads (again)
My profile is up to date, but, briefly, have failed chemo, ADT (am castrate resistant), failed Keytruda and now Pluvicto. Scans yest. & today show progression along with PSA rise. All my mets are in bone. So, my SOC choices are cabazataxel or radium 223. Other options are trial, which are a crapshoot
My profile is up to date, but, briefly, have failed chemo, ADT (am castrate resistant), failed Keytruda and now Pluvicto. Scans yest. & today show progression along with PSA rise. All my mets are in bone. So, my SOC choices are cabazataxel or radium 223. Other options are trial, which are a crapshoot
rsgdmd
in
Advanced Prostate Cancer
4 months ago
Is This Normal??
Is it normal after nearly 5 years on ADT + Zytig, Prednisone, and Xgeva, to have constant "Flu-Like" symptoms, (sans a fever)? Some days, everything hurts, legs hurt at night , feel like my blood is boiling while I try to sleep. Are these "side effects" or just part of the advanced cancer? Excruciating
Is it normal after nearly 5 years on ADT + Zytig, Prednisone, and Xgeva, to have constant "Flu-Like" symptoms, (sans a fever)? Some days, everything hurts, legs hurt at night , feel like my blood is boiling while I try to sleep. Are these "side effects" or just part of the advanced cancer? Excruciating
TommyCarz2
in
Advanced Prostate Cancer
4 months ago
Gynecomastia from ADT - how much?
Gynecomastia from ADT - how much? I am considering asking my oncologist for transdermal estrogn (TDE) therapy instead of Orgovyx to combat my prostate cancer. Since gynecomastia and breast pain are pretty much the only bad side effects from TDE and less troubling to me than metabolic disturbance,
Gynecomastia from ADT - how much? I am considering asking my oncologist for transdermal estrogn (TDE) therapy instead of Orgovyx to combat my prostate cancer. Since gynecomastia and breast pain are pretty much the only bad side effects from TDE and less troubling to me than metabolic disturbance,
Lost_Sheep
in
Prostate Cancer Network
4 months ago
Took my ndt at 3pm. Blood test at 08.40 in the morning! Have I messed up??
Hi guys, I'm on NDT. I've been waiting a while for a blood test as I have a lot going on, not just thyroid. Will the blood test result be ok? Feel so stupid! TIA
Hi guys, I'm on NDT. I've been waiting a while for a blood test as I have a lot going on, not just thyroid. Will the blood test result be ok? Feel so stupid! TIA
KornishPiskie
in
Thyroid UK
4 months ago
OS versus Testosterone Nadir - 5
This plot shows the Overall Survival Probability after RT and ADT, for Advance Prostate Cancer men, comparing two different ranges of testosterone nadir (< 10 ng/dL, and 10-20 ng/dL) after 11 years. The
best
outcomes
are significantly associated with a
lower testosterone nadir ( <
This plot shows the Overall Survival Probability after RT and ADT, for Advance Prostate Cancer men, comparing two different ranges of testosterone nadir (< 10 ng/dL, and 10-20 ng/dL) after 11 years. The
best
outcomes
are significantly associated with a
lower testosterone nadir ( <
janebob99
in
Advanced Prostate Cancer
4 months ago
OS versus Testosterone Nadir - 4
This plot shows the Overall Survival Probability after RT and ADT, for Advance Prostate Cancer men, comparing different levels of testosterone nadir (< 10 ng/dL, 10-20, and 20-50, The
best
outcomes
are significantly associated with a
lower testosterone nadir ( < 10 ng/dL).
[b
This plot shows the Overall Survival Probability after RT and ADT, for Advance Prostate Cancer men, comparing different levels of testosterone nadir (< 10 ng/dL, 10-20, and 20-50, The
best
outcomes
are significantly associated with a
lower testosterone nadir ( < 10 ng/dL).
[b
janebob99
in
Advanced Prostate Cancer
4 months ago
PSA relapse rate vs testosterone nadir - 3
This plot shows the PSA relapse rate after RT and ADT, for Intermediate and High Risk men, comparing different levels of testosterone nadir ( 50 nd/dL). (ref: 2019) The
best
outcomes
are significantly associated with a
lower testosterone nadir ( < 20 ng/dL),
and the relationship
This plot shows the PSA relapse rate after RT and ADT, for Intermediate and High Risk men, comparing different levels of testosterone nadir ( 50 nd/dL). (ref: 2019) The
best
outcomes
are significantly associated with a
lower testosterone nadir ( < 20 ng/dL),
and the relationship
janebob99
in
Advanced Prostate Cancer
4 months ago
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