New 2024 AUA/ASTRO/SUO Guidelines for... - Advanced Prostate...

Advanced Prostate Cancer

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New 2024 AUA/ASTRO/SUO Guidelines for Salvage Therapy

Tall_Allen profile image
14 Replies

auanet.org/guidelines-and-q...

Not surprising. I think they should recommend adjuvant ADT at a PSA≥0.35 instead of ≥0.7 because I think patients are hoping for curative SRT and not just equivalent survival.

prostatecancer.news/2022/05...

Also, they did not incorporate the results of the EMBARK and PRESTO trials that proved the benefits of adding Xtandi and Erleada, respectively, for a non-metastatic recurrence when the PSADT is rapid.

prostatecancer.news/2023/05...

prostatecancer.news/2022/09...

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Tall_Allen profile image
Tall_Allen
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cesces profile image
cesces

Thank you for the post and for the links

dans_journey profile image
dans_journey

Thanks for sharing, Allen.

GMorz profile image
GMorz

thanks so much . Is there a number they classified psa detectable or is it any psa above zero?

Tall_Allen profile image
Tall_Allen in reply toGMorz

Whether PSA is detectable or not only depends upon the sensitivity of the particular PSA test. The arbitrary definition of biochemical recurrence hasn't changed (0.2).

GMorz profile image
GMorz in reply toTall_Allen

Thank you for replying

GreenStreet profile image
GreenStreet

Based on some previous research I saw earlier but can’t recall I thought that 3 PSA rises if PSA above 0.03 gave best result of cure. I think my ST which did not work was administered at 0.06 with my PSA post operation at 0.06 and then went down gradually to 0.03 but no lower. Trigger was pulled when three successive PSA rises of 0.01 took it back to 0.06. Had 6 months HT too. That was back in 2017.

Tall_Allen profile image
Tall_Allen in reply toGreenStreet

In 2017, that was the best info we had.

Elbers123 profile image
Elbers123

Ironically I’m heading to a salvage discussion today. I will be asking , among other things, about ADT and combining a gen 1 and next gen to the treatment. As I read the new guidelines they only offer this on a trial. I’ll mention the embark trial and see where it goes.

Tall_Allen profile image
Tall_Allen in reply toElbers123

You don't seem to meet the EMBARK criteria for PSA and PSADT. It is only for men for whom curative salvage is out of the picture, not you.

The SOC for you is prostate bed radiation + 4-6 months of ADT.

Elbers123 profile image
Elbers123 in reply toTall_Allen

Thanks. I had a great discussion with the doctors. They were the obvious experts in the room. Yet they took the time to go over my case and how it aligned with the recent salvage and BCR trials. They also are having a decipher test run. I’ll prob end up exactly SOC but they will let tests come back first.

God_Loves_Me profile image
God_Loves_Me

Whats are the medicine combinations or ADT + enzalutamide ? I am not sure what are the ADT ?

Tall_Allen profile image
Tall_Allen in reply toGod_Loves_Me

ADT=androgen deprivation therapy = any of several medicines that prevent the testes from manufacturing testosterone (e.g., Lupron, Firmagon, Orgovyx, Eligard, Zoladex, or orchiectomy)

God_Loves_Me profile image
God_Loves_Me in reply toTall_Allen

Oh i thought how someone can do bicalutamide + xtandi

Tall_Allen profile image
Tall_Allen in reply toGod_Loves_Me

Bicalutamide is seldom used as the sole form of ADT in the US

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