Con't know if it's good for metastatic but still...CRPC is good enough
Molecule name: AZD5069
“This is tremendously exciting and it suggests we have an entirely new way to treat prostate cancer on the horizon,” said Johann de Bono, a professor of experimental cancer medicine at the Institute of Cancer Research and consultant medical oncologist at the Royal Marsden NHS foundation trust.
In a trial led by the ICR, the Royal Marsden and the Institute of Oncology Research in Switzerland, scientists recruited 23 patients with advanced prostate cancer that had stopped responding to hormone therapy.
They were given a combination of AZD5069, an experimental drug that prevents white blood cells from being dragged inside tumours, and enzalutamide, a hormone therapy commonly used to treat prostate cancer.
Of 21 patients who could be evaluated, five (24%) showed evidence of their tumours responding to the combination, the ICR reported.
Their tumours shrunk by more than 30%, they experienced “dramatic decreases” in circulating levels of prostate specific antigen (PSA), a marker often elevated by cancer, or their blood levels of circulating tumour cells dropped, it said.