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Enzalutamide
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The MAO inhibitors phenelzine and clorgyline revert enzalutamide resistance in castration resistant prostate cancer
I am not using enza (yet) wondering if it's worth taking some nutmeg to keep those mao in check anyway! :-P https://www.nature.com/articles/s41467-020-15396-5
I am not using enza (yet) wondering if it's worth taking some nutmeg to keep those mao in check anyway! :-P https://www.nature.com/articles/s41467-020-15396-5
Maxone73
in
Fight Prostate Cancer
4 months ago
Making a Case for Intermittent ADT in Metastatic Hormone Sensitive Prostate Cancer
Some on this site are now on monotherapy with bicalutamide,
enzalutamide
, apalutamide or darolutamide, and doing well... A study that involves those options along with using SBRT in oligometastatic disease could change the current SOC... Consider this a call for new studies...
Some on this site are now on monotherapy with bicalutamide,
enzalutamide
, apalutamide or darolutamide, and doing well... A study that involves those options along with using SBRT in oligometastatic disease could change the current SOC... Consider this a call for new studies...
NPfisherman
in
Fight Prostate Cancer
25 days ago
Could I try BAT to restore sensitivity to previously used antiandrogen treatments.
I failed Abiraterone and SOC doesn't allow the switch to
Enzalutamide
. I was reading on the use of BAT to resensitize mCRPC. Would this be a therapy that could work or is it too late now that I have failed. I know its not SOC but I am running out of choices and looking for some clarity.
I failed Abiraterone and SOC doesn't allow the switch to
Enzalutamide
. I was reading on the use of BAT to resensitize mCRPC. Would this be a therapy that could work or is it too late now that I have failed. I know its not SOC but I am running out of choices and looking for some clarity.
Islandboy2021
in
Advanced Prostate Cancer
8 months ago
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How long to Castrate Resistance: ADT+/- ARSI
Another measure is PSA progression which is available for all groups as a proxy for regimen failure: This is 2.3% (8/355) for ADT+E combo; 26% (93/358) for ADT mono; and 10% (37/355) for
Enzalutamide
monotherapy. Paul/MateoBeach
Another measure is PSA progression which is available for all groups as a proxy for regimen failure: This is 2.3% (8/355) for ADT+E combo; 26% (93/358) for ADT mono; and 10% (37/355) for
Enzalutamide
monotherapy. Paul/MateoBeach
MateoBeach
in
Advanced Prostate Cancer
7 months ago
Phase III Study: Saruparib Combo with New Hormonal Agents in mCSPC +/- HRR Mutations: AUA 2024 EvoPAR-Prostate01 Trial
The safety and efficacy of saruparib plus new hormonal agents for the treatment of mCSPC and mCRPC are being assessed in the Phase I/IIa PETRANHA study (NCT05367440), with the initial data indicated that saruparib (60 mg QD) can be safely combined with
enzalutamide
, abiraterone acetate, or darolutamide
The safety and efficacy of saruparib plus new hormonal agents for the treatment of mCSPC and mCRPC are being assessed in the Phase I/IIa PETRANHA study (NCT05367440), with the initial data indicated that saruparib (60 mg QD) can be safely combined with
enzalutamide
, abiraterone acetate, or darolutamide
God_Loves_Me
in
Advanced Prostate Cancer
25 days ago
ADT or not?
Hi, i have Stage 4 PCA, Gleason 5+4 so I am on Degaralix and
Enzalutamide
. I tend to refer to this treatment as ADT as shorthand because to my mind they both reduce testosterone. I wonder if I’m misusing ADT or does it matter?
Hi, i have Stage 4 PCA, Gleason 5+4 so I am on Degaralix and
Enzalutamide
. I tend to refer to this treatment as ADT as shorthand because to my mind they both reduce testosterone. I wonder if I’m misusing ADT or does it matter?
FortyWinks
in
Advanced Prostate Cancer
9 months ago
Need help understanding Enzalutamide
Help us understand what to expect with the SE of
Enzalutamide
. Soapchick
Help us understand what to expect with the SE of
Enzalutamide
. Soapchick
Hidden
in
Advanced Prostate Cancer
9 months ago
Post Degaralix
I know it’s doing it’s thing, along with
enzalutamide
but feeling my quality of life balance is tipping to far the other way. Hoping I’ll feel differently by the end of today.
I know it’s doing it’s thing, along with
enzalutamide
but feeling my quality of life balance is tipping to far the other way. Hoping I’ll feel differently by the end of today.
FortyWinks
in
Advanced Prostate Cancer
8 months ago
The Science is Coming
Good to see the mini AZD5069 trial with
enzalutamide
offering another route to taming the beast. I am no scientist but as I understand it the target is myeloid white blood cells which can act to fuel tumours.
Good to see the mini AZD5069 trial with
enzalutamide
offering another route to taming the beast. I am no scientist but as I understand it the target is myeloid white blood cells which can act to fuel tumours.
GreenStreet
in
Prostate Cancer Network
8 months ago
Xtandi and insomnia
Anybody else have severe insomnia from
enzalutamide
? I'm only getting ~3 hours sleep since starting. Pretty deep fatigue too. Any advice on ways to manage this?
Anybody else have severe insomnia from
enzalutamide
? I'm only getting ~3 hours sleep since starting. Pretty deep fatigue too. Any advice on ways to manage this?
Djangler
in
Advanced Prostate Cancer
10 months ago
New combo shows promising results in clinical trial: enzalutamide plus CC-115
https://www.x-mol.net/paper/article/1726434947306901504
https://www.x-mol.net/paper/article/1726434947306901504
Maxone73
in
Advanced Prostate Cancer
6 months ago
AUA 2023: PSA Response and Time-to-Castration Resistance Among Patients with mCSPCa Initiated on Apalutamide, Enzalutamide, or Abiraterone
on all measures
enzalutamide
ranked 2nd on all measures abiraterone ranked 3rd on all measures ------------------------------------------------------- [u]How much should I care?
on all measures
enzalutamide
ranked 2nd on all measures abiraterone ranked 3rd on all measures ------------------------------------------------------- [u]How much should I care?
skiingfiend
in
Advanced Prostate Cancer
10 months ago
Switching from Abi to Enza?
My father has become pre-diabetic now and the doctor has advised to switch to
Enzalutamide
as it has fewer side effects. I wanted to check if anyone else did something like this (switching to Enza when Abi is still working), and whether you think this is a good idea? Many thanks in advance.
My father has become pre-diabetic now and the doctor has advised to switch to
Enzalutamide
as it has fewer side effects. I wanted to check if anyone else did something like this (switching to Enza when Abi is still working), and whether you think this is a good idea? Many thanks in advance.
Rodeoz15
in
Advanced Prostate Cancer
9 months ago
BAT Patient Guide
"A larger randomized study comparing overall patient survival following treatment with sequential BAT → Xtandi versus
enzalutamide
or chemotherapy alone will be required to obtain FDA approval of this approach.
"A larger randomized study comparing overall patient survival following treatment with sequential BAT → Xtandi versus
enzalutamide
or chemotherapy alone will be required to obtain FDA approval of this approach.
dhccpa
in
Advanced Prostate Cancer
8 months ago
More Evidence Linking ADT for PCa to Adverse Neurocognitive Effects -Meta-analysis shows increased risk of dementia, Parkinson's, depression
The risk was even higher in men treated with newer androgen receptor signaling inhibitors (ARSIs), but the association was not consistent across the ARSI class: increased risk with
enzalutamide
(Xtandi) and apalutamide (Erleada) but decreased risk with abiraterone (Zytiga).
The risk was even higher in men treated with newer androgen receptor signaling inhibitors (ARSIs), but the association was not consistent across the ARSI class: increased risk with
enzalutamide
(Xtandi) and apalutamide (Erleada) but decreased risk with abiraterone (Zytiga).
cujoe
in
Fight Prostate Cancer
5 months ago
Just been told I have two years to live.
Since then, been on
Enzalutamide
(sourced from India). No side effects except exhaustion. Too early to tell if working. Yesterday, oncologist said I have two years to live. PSA 135. Totally shocked. Anyone had similar experience? Is it worth getting a second opinion? Any suggestions?
Since then, been on
Enzalutamide
(sourced from India). No side effects except exhaustion. Too early to tell if working. Yesterday, oncologist said I have two years to live. PSA 135. Totally shocked. Anyone had similar experience? Is it worth getting a second opinion? Any suggestions?
ChristopherM123
in
Advanced Prostate Cancer
9 months ago
Very promising trial!
They were given a combination of AZD5069, an experimental drug that prevents white blood cells from being dragged inside tumours, and
enzalutamide
, a hormone therapy commonly used to treat prostate cancer.
They were given a combination of AZD5069, an experimental drug that prevents white blood cells from being dragged inside tumours, and
enzalutamide
, a hormone therapy commonly used to treat prostate cancer.
Maxone73
in
Advanced Prostate Cancer
8 months ago
The University of California has raked in a previously undisclosed $1.6 billion from Xtandi sales sales
UCLA chemist Michael Jung designed a molecule called
enzalutamide
, known commercially as Xtandi.
UCLA chemist Michael Jung designed a molecule called
enzalutamide
, known commercially as Xtandi.
rsgdmd
in
Advanced Prostate Cancer
2 months ago
Using Provenge before AR inhibitors.
https://www.urologytimes.com/view/sipuleucel-t-boosts-survival-versus-abiraterone-or-
enzalutamide
-alone-in-real-world-mcrpc-analysis
https://www.urologytimes.com/view/sipuleucel-t-boosts-survival-versus-abiraterone-or-
enzalutamide
-alone-in-real-world-mcrpc-analysis
dhccpa
in
Advanced Prostate Cancer
15 days ago
Radium223 has not been a success, is Enzalutamide a good next option?
Now doctors are suggesting that possible option is to switch onto Xtandi/
Enzalutamide
. Anyone in the same or similar situation? Any advice would be welcomed .... Thanks
Now doctors are suggesting that possible option is to switch onto Xtandi/
Enzalutamide
. Anyone in the same or similar situation? Any advice would be welcomed .... Thanks
Ronnie7C
in
Advanced Prostate Cancer
10 months ago
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