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Phase 3 Positive Topline Results for Tavapadon
By selectively activating D1/D5
dopamine
receptors along the nigrostriatal pathway, tavapadon has the potential to offer the right balance of
dopamine
signaling to
improve motor control while avoiding D2/D3 overstimulation, which is believed to underlie many of the side effects of current
By selectively activating D1/D5
dopamine
receptors along the nigrostriatal pathway, tavapadon has the potential to offer the right balance of
dopamine
signaling to
improve motor control while avoiding D2/D3 overstimulation, which is believed to underlie many of the side effects of current
nednedned
in
Cure Parkinson's
3 months ago
Dopamine the problem?
Is
dopamine
and possibly c/l making things worse? Seems kinda like Dr. Sackler Bernstein is saying. My fear is mindless taking CL will burn me later... Any thoughts? https://www.science.org/content/article/
dopamine
-may-exacerbate-parkinsons-disease
Is
dopamine
and possibly c/l making things worse? Seems kinda like Dr. Sackler Bernstein is saying. My fear is mindless taking CL will burn me later... Any thoughts? https://www.science.org/content/article/
dopamine
-may-exacerbate-parkinsons-disease
stocktiki
in
Cure Parkinson's
5 months ago
Next NoSilverBullet webinar on 17th of June: Sackner-Bernstein, MD, on "Why I am optimistic that we might now have a Silver Bullet for PD".
First, he discovered that the brain cells (dopaminergic neurons) in Parkinson’s patients are exposed to excess
dopamine
, reaching toxic levels.
First, he discovered that the brain cells (dopaminergic neurons) in Parkinson’s patients are exposed to excess
dopamine
, reaching toxic levels.
Michel0220
in
Cure Parkinson's
2 months ago
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Going bananas
Has anyone tried tried just bananas for
dopamine
?https://www.researchgate.net/publication/12591094_High_Content_of_Dopamine_a_Strong_Antioxidant_in_Cavendish_Banana#:~:text=Banana%20contained%20dopamine%20at%20high,one%20of%20the%20antioxidative%20foods.
Has anyone tried tried just bananas for
dopamine
?https://www.researchgate.net/publication/12591094_High_Content_of_Dopamine_a_Strong_Antioxidant_in_Cavendish_Banana#:~:text=Banana%20contained%20dopamine%20at%20high,one%20of%20the%20antioxidative%20foods.
PDCyclist
in
Cure Parkinson's
4 months ago
Rhodiola may increase dopamine sensitivity
https://draxe.com/nutrition/rhodiola-rosea/
https://draxe.com/nutrition/rhodiola-rosea/
Dabaa
in
Cure Parkinson's
2 months ago
Experience with tapering Neupro, Dopamine Agonists, and managing DAWS
I'm particularly interested in hearing from those who have experienced
dopamine
agonist withdrawal syndrome (DAWS), as documented in scientific literature.
I'm particularly interested in hearing from those who have experienced
dopamine
agonist withdrawal syndrome (DAWS), as documented in scientific literature.
WittyPD
in
Cure Parkinson's
1 month ago
Has anyone done an Organic Acid Test(OAT)?
I can usually sort out test results well enough but these
dopamine
related neurotransmitters have me baffled so I may pay extra for a consultation. Thanks!
I can usually sort out test results well enough but these
dopamine
related neurotransmitters have me baffled so I may pay extra for a consultation. Thanks!
Debgiffen
in
Cure Parkinson's
2 months ago
How do I taper .50mg pram?
Also has anyone use supplements to help with the drop in
dopamine
? Like l tyrosine or any supplements that increase
dopamine
? Thanks so much!
Also has anyone use supplements to help with the drop in
dopamine
? Like l tyrosine or any supplements that increase
dopamine
? Thanks so much!
loloball2
in
Restless Legs Syndrome
4 months ago
Unleashing the Power of Intensive Brain Training in Parkinson's: Promising Findings
Nine out of ten participants experienced this increase, suggesting improved functioning of existing
dopamine
neurons. Neuromelanin levels also displayed an average increase, albeit with more variability among participants.
Nine out of ten participants experienced this increase, suggesting improved functioning of existing
dopamine
neurons. Neuromelanin levels also displayed an average increase, albeit with more variability among participants.
Esperanto
in
Cure Parkinson's
3 months ago
Piperine and L-dopa producing probiotic
Testing in animals showed that it can achieve consistent L-DOPA levels in blood plasma and steady brain
dopamine
levels without any unwanted fluctuation.
Testing in animals showed that it can achieve consistent L-DOPA levels in blood plasma and steady brain
dopamine
levels without any unwanted fluctuation.
Rufous2
in
Cure Parkinson's
2 months ago
Exercise & PD
I.e. are there cases of DAT scans showing an improvement in
dopamine
? Have they actually had PD in the first place? Does it mean they improve on non-motor symptoms? Some take less medication due to exercise - so
dopamine
must increase naturally to enable function?
I.e. are there cases of DAT scans showing an improvement in
dopamine
? Have they actually had PD in the first place? Does it mean they improve on non-motor symptoms? Some take less medication due to exercise - so
dopamine
must increase naturally to enable function?
forest1
in
Cure Parkinson's
4 months ago
My niece
I've warned her against taking
dopamine
agonists. Please recommend any doctor in the Birmingham UK area. She is even willing to go to London
I've warned her against taking
dopamine
agonists. Please recommend any doctor in the Birmingham UK area. She is even willing to go to London
Coeso
in
Restless Legs Syndrome
3 months ago
Which treatment after dopamine agonist withdrawal?
I'm currently fighting to withdraw from
dopamine
agonist (DA) after a severe augmentation. I was prescribed some other drugs to help me go through this process (tramadol, pregabaline, clonazepan, wellbrutin).
I'm currently fighting to withdraw from
dopamine
agonist (DA) after a severe augmentation. I was prescribed some other drugs to help me go through this process (tramadol, pregabaline, clonazepan, wellbrutin).
Mikatrap
in
Restless Legs Syndrome
1 month ago
Dr Berkowski Article on Dopamine Agonists Oct '23.
https://www.calameo.com/sleeplabmagazine/books/006372046fb2b80cd3776 Dr Berkowski is one of the top US experts on RLS and he firmly believes
dopamine
agonists cause permanent damage to
dopamine
receptors. This means pregabalin and gabapentin often don't work for us, nor do iron infusions.
https://www.calameo.com/sleeplabmagazine/books/006372046fb2b80cd3776 Dr Berkowski is one of the top US experts on RLS and he firmly believes
dopamine
agonists cause permanent damage to
dopamine
receptors. This means pregabalin and gabapentin often don't work for us, nor do iron infusions.
Joolsg
in
Restless Legs Syndrome
6 months ago
advice about intravenous iron
On Levodopa and
dopamine
agonists like ropinorole and pramipexole. Lately hemoglobin levels has fallen quite a lot from 11.1 gm% in Jan 2024.
On Levodopa and
dopamine
agonists like ropinorole and pramipexole. Lately hemoglobin levels has fallen quite a lot from 11.1 gm% in Jan 2024.
Divii
in
Cure Parkinson's
16 days ago
advice about iron infusion
On Levodopa and
dopamine
agonists like ropinorole and pramipexole. Lately hemoglobin levels has fallen quite a lot from 11.1 gm% in Jan 2024.
On Levodopa and
dopamine
agonists like ropinorole and pramipexole. Lately hemoglobin levels has fallen quite a lot from 11.1 gm% in Jan 2024.
Divii
in
Pernicious Anaemia Society
16 days ago
Asking for a friend re patient leaflet info in the UK
If it was on the leaflet when my friend started on
Dopamine
Agonist meds but her GP didn't warn about it and kept increasing the Ropinerole to extremely high doses when augmentation was obviously happening could there still be a claim for negligence.
If it was on the leaflet when my friend started on
Dopamine
Agonist meds but her GP didn't warn about it and kept increasing the Ropinerole to extremely high doses when augmentation was obviously happening could there still be a claim for negligence.
Pippins2
in
Restless Legs Syndrome
23 days ago
Patients with Parkinson’s disease (PD) report a strong craving for sweets
[u]
Consuming food with a high-sugar content is assumed to lead to an increase in insulin concentration, which could positively influence
concentration in the brain and unconsciously be used by patients as kind of “self-medication” to compensate for a lack of
dopamine
[/u]
in PD.
[u]
Consuming food with a high-sugar content is assumed to lead to an increase in insulin concentration, which could positively influence
concentration in the brain and unconsciously be used by patients as kind of “self-medication” to compensate for a lack of
dopamine
[/u]
in PD.
Bolt_Upright
in
Cure Parkinson's
5 months ago
Dopamine Agonist Withdrawal Syndrome (DAWS)
https://dc.etsu.edu/asrf/2024/schedule/123/ A case report of DAWS presenting as confusion, emotional liability and headache. Most of us who have been through withdrawal from Ropinirole, Pramipexole and Neupro recognise these symptoms, but hopefully, this article and others will help doctors to understand
https://dc.etsu.edu/asrf/2024/schedule/123/ A case report of DAWS presenting as confusion, emotional liability and headache. Most of us who have been through withdrawal from Ropinirole, Pramipexole and Neupro recognise these symptoms, but hopefully, this article and others will help doctors to understand
Joolsg
in
Restless Legs Syndrome
4 months ago
Update on STEM-PD clinical trial – stem cell-based transplant for Parkinson’s disease
Secondary objectives of the trial include assessment of transplanted cell survival through
dopamine
PET imaging as well as evaluation of clinical efficacy three years post transplantation.
Secondary objectives of the trial include assessment of transplanted cell survival through
dopamine
PET imaging as well as evaluation of clinical efficacy three years post transplantation.
nednedned
in
Cure Parkinson's
2 months ago
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