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Looking for Estrogen Users...
Hello, I'm doing a survey of estrogen users. I'd like to find out: 1. How many patches or gel pumps do you use a day, or a week? And what dose of E2 patches do you use? 2. What's your PSA? 3. What's your estradiol? 4. What's your testosterone? 5. What's your DHT (if you measure it)? 6. How
Hello, I'm doing a survey of estrogen users. I'd like to find out: 1. How many patches or gel pumps do you use a day, or a week? And what dose of E2 patches do you use? 2. What's your PSA? 3. What's your estradiol? 4. What's your testosterone? 5. What's your DHT (if you measure it)? 6. How
janebob99
in
Advanced Prostate Cancer
7 months ago
Low testosterone is associated with extremely poor survival metrics, post-ADT.
These companion plots compare: (A) median survival times, (B) PSA doubling times, and (C) Time to PSA Failure for two different levels of testosterone: Low and Normal. The low testosterone has a median value of 162 ng/dL [120-236] and the average normal T = 680 ng/dL. The cohort is 58 men with unfavorable
These companion plots compare: (A) median survival times, (B) PSA doubling times, and (C) Time to PSA Failure for two different levels of testosterone: Low and Normal. The low testosterone has a median value of 162 ng/dL [120-236] and the average normal T = 680 ng/dL. The cohort is 58 men with unfavorable
janebob99
in
Prostate Cancer Network
7 months ago
My own PSA values over time: 70% drop in just 3 months on Dutasteride and no ADT
Here are my own PSA values versus time plot. You can see there is an exponential rise in PSA starting at around 6/1/23, and doubling from PSA = 5 to 10 in about 8 months. My MRI at PSA = 10 showed a T3a tumor about 1.3 cm long (PIRADS 5). A subsequent targeted biopsy showed Gleason 3+4 in 4 cores,
Here are my own PSA values versus time plot. You can see there is an exponential rise in PSA starting at around 6/1/23, and doubling from PSA = 5 to 10 in about 8 months. My MRI at PSA = 10 showed a T3a tumor about 1.3 cm long (PIRADS 5). A subsequent targeted biopsy showed Gleason 3+4 in 4 cores,
janebob99
in
Prostate Cancer Network
7 months ago
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Doubling Times and PSA acceleration - Part II
This is a more realistic schematic plot of PSA levels increasing over time at an ever faster rate (acceleration). What could cause this? My theory is that as the tumor grows, the number of androgen receptors (ARs) increases proportionally. That makes sense...more PCa cells inside a tumor...more ARs
This is a more realistic schematic plot of PSA levels increasing over time at an ever faster rate (acceleration). What could cause this? My theory is that as the tumor grows, the number of androgen receptors (ARs) increases proportionally. That makes sense...more PCa cells inside a tumor...more ARs
janebob99
in
Prostate Cancer Network
7 months ago
PSA levels will increase over time, depending on the level of testosterone - Part I
Here's a schematic plot of the increase in PSA level (or increase in tumor volume) over time, for various levels of testosterone (while the tumor is relatively small). At very low levels of testosterone (for example, T = 10 ng/dL), the increase in PSA level is very small after a given time (for example
Here's a schematic plot of the increase in PSA level (or increase in tumor volume) over time, for various levels of testosterone (while the tumor is relatively small). At very low levels of testosterone (for example, T = 10 ng/dL), the increase in PSA level is very small after a given time (for example
janebob99
in
Prostate Cancer Network
7 months ago
Baseline PSMA-Pet scan?
My MO has given me instructions to end treatment 7/31. I've been on Lupron & Zytiga/5mg prednisone since 8/1/2022. I started out with Gleason (3+4) 7. Last May I had pelvic radiation to hit lymph nodes as per a 2021 PSMA-Pet scan. Now it's time to stop all treatment at the 2 year mark. My MO just kind
My MO has given me instructions to end treatment 7/31. I've been on Lupron & Zytiga/5mg prednisone since 8/1/2022. I started out with Gleason (3+4) 7. Last May I had pelvic radiation to hit lymph nodes as per a 2021 PSMA-Pet scan. Now it's time to stop all treatment at the 2 year mark. My MO just kind
duxlubber
in
Advanced Prostate Cancer
7 months ago
Shawty got low, low, low, & the Beat goes On. PSA update!
https://youtu.be/ckKFxMw6z0c?si=uEmAdIKQg-1jg-Hw https://youtu.be/9lkfrtztqEY?si=EBG_OJ3pB1LcBRQ0 I dunno why it's still droppin' almost a year post 28 IMRTs but I ain't gon complain 😜 Maybe I have Someone to watch over me https://youtu.be/g8J2Gb-hMIY?si=FYnNKgYTgkpdC4ud Life is Beautiful https
https://youtu.be/ckKFxMw6z0c?si=uEmAdIKQg-1jg-Hw https://youtu.be/9lkfrtztqEY?si=EBG_OJ3pB1LcBRQ0 I dunno why it's still droppin' almost a year post 28 IMRTs but I ain't gon complain 😜 Maybe I have Someone to watch over me https://youtu.be/g8J2Gb-hMIY?si=FYnNKgYTgkpdC4ud Life is Beautiful https
dockam
in
Advanced Prostate Cancer
7 months ago
Result of Liver Biopsy - Any Insights?
This is the result of my liver biposy. Any insights on the comment? ----- CLINICAL HISTORY>>:: Prostate Ca with hepatic mets ?Small cell transformation versus other. FINAL DIAGNOSIS>>:: LIVER NODULE, CORE BIOPSY: - POORLY DIFFERENTIATED PROSTATIC ADENOCARCINOMA WITH SMALL CELL TRANSFORMATION
This is the result of my liver biposy. Any insights on the comment? ----- CLINICAL HISTORY>>:: Prostate Ca with hepatic mets ?Small cell transformation versus other. FINAL DIAGNOSIS>>:: LIVER NODULE, CORE BIOPSY: - POORLY DIFFERENTIATED PROSTATIC ADENOCARCINOMA WITH SMALL CELL TRANSFORMATION
skiingfiend
in
Advanced Prostate Cancer
7 months ago
Interesting study on combination of statins and metformin in high-risk patient outcomes
https://www.academia.edu/99363002/Individual_and_joint_effects_of_metformin_and_statins_on_mortality_among_patients_with_high_risk_prostate_cancer?email_work_card=view-paper Interesting paper - basically showing that statins reduce PCa mortality among high-risk PCa patients, metformin doesn't appear
https://www.academia.edu/99363002/Individual_and_joint_effects_of_metformin_and_statins_on_mortality_among_patients_with_high_risk_prostate_cancer?email_work_card=view-paper Interesting paper - basically showing that statins reduce PCa mortality among high-risk PCa patients, metformin doesn't appear
Don_1213
in
Advanced Prostate Cancer
7 months ago
Non metastasis castrate resistant
When you are on ADT and become Non metastatic Castrate resistant and your testosterone levels are below zero, what is the cancer feeding off to cause the PSA to still rise? Hoping for your replies so as to give me some understanding. Thank you.
When you are on ADT and become Non metastatic Castrate resistant and your testosterone levels are below zero, what is the cancer feeding off to cause the PSA to still rise? Hoping for your replies so as to give me some understanding. Thank you.
Sailameme
in
Advanced Prostate Cancer
7 months ago
High risk vs. aggressive cancer
I understand the definition of high-risk prostate cancer (Gleason, PSA and/or spread), but that doesn't necessarily seem to be the same thing as aggressive cancer. How can aggressiveness be determined for high risk, localized cancer? Thanks for any insight and information.
I understand the definition of high-risk prostate cancer (Gleason, PSA and/or spread), but that doesn't necessarily seem to be the same thing as aggressive cancer. How can aggressiveness be determined for high risk, localized cancer? Thanks for any insight and information.
RugbyVLS
in
Advanced Prostate Cancer
7 months ago
MY pBAT Stats From June to March 8 months
Hi All, Just thought I would give an update on my pBAT (Testosterone propianate BAT) for the last 8 months. I do T propianate injections every other day while on High T for 2 weeks then slam the door with Darolutamide for 2 weeks and then one week to clear the Daro. Rinse and repeat. I also take intermittent
Hi All, Just thought I would give an update on my pBAT (Testosterone propianate BAT) for the last 8 months. I do T propianate injections every other day while on High T for 2 weeks then slam the door with Darolutamide for 2 weeks and then one week to clear the Daro. Rinse and repeat. I also take intermittent
KocoPr
in
Fight Prostate Cancer
7 months ago
Problems
Hi everyone thanks for all your replies it was so helpful 😁 one thing more if you could help I have been in afib since last Monday and it won't settle can this be normal,I am as I said waiting for some more tests and then see the specialist but finding it hard to keep going through this at the moment
Hi everyone thanks for all your replies it was so helpful 😁 one thing more if you could help I have been in afib since last Monday and it won't settle can this be normal,I am as I said waiting for some more tests and then see the specialist but finding it hard to keep going through this at the moment
bobify
in
Atrial Fibrillation Support
1 year ago
Revised Plot of PSA vs Testosterone: Estrogen vs Lupron ADT
Ugh...I made a BIG mistake on the previous posting! I just realized that Dr. Morgentaler had listed the Testosterone level in unusual units (
ng/mL
), not the usual units of (
ng/dL)
. So, my X-axis was off by a factor of 10. Here is the revised plot. The exciting discovery is that the
Ugh...I made a BIG mistake on the previous posting! I just realized that Dr. Morgentaler had listed the Testosterone level in unusual units (
ng/mL
), not the usual units of (
ng/dL)
. So, my X-axis was off by a factor of 10. Here is the revised plot. The exciting discovery is that the
janebob99
in
Advanced Prostate Cancer
7 months ago
Morgentaler Saturation Model: PSA vs Testosterone - Estrogen Patch vs Lupron ADT
This is a plot of % reduction in PSA from a Maximum Value versus Testosterone, for two different datasets: Estrogen Patch and Lupron ADT. Both curves (red and green lines) show a linear response starting from (0,0), up to about 200-250 ng/dL. Then, the lines curve over to a lower slope (especially
This is a plot of % reduction in PSA from a Maximum Value versus Testosterone, for two different datasets: Estrogen Patch and Lupron ADT. Both curves (red and green lines) show a linear response starting from (0,0), up to about 200-250 ng/dL. Then, the lines curve over to a lower slope (especially
janebob99
in
Advanced Prostate Cancer
7 months ago
PSA vs Testosterone at high T levels - Linear Model
This is a plot of PSA versus Testosterone in men with prostate cancer. The blue points are taken from a YouTube video lecture by A. Morgentaler (2020). https://www.youtube.com/watch?v=wafNZV-Hkqk The green point is from Safraidi (2022): https://oamjms.eu/index.php/mjms/article/view/9388 Note the
This is a plot of PSA versus Testosterone in men with prostate cancer. The blue points are taken from a YouTube video lecture by A. Morgentaler (2020). https://www.youtube.com/watch?v=wafNZV-Hkqk The green point is from Safraidi (2022): https://oamjms.eu/index.php/mjms/article/view/9388 Note the
janebob99
in
Advanced Prostate Cancer
7 months ago
PSMA Scan to be scheduled - thank you Tall Allen
I want to thank Tall Allen for his suggestion that I see an oncologist. I had a RP followed by radiation in 2013. My PSA was undetectable until 2021, when it started to rise. This week I saw a radiation oncologist (whom I found through a friend) to ask him a lot of questions and to get his advice.
I want to thank Tall Allen for his suggestion that I see an oncologist. I had a RP followed by radiation in 2013. My PSA was undetectable until 2021, when it started to rise. This week I saw a radiation oncologist (whom I found through a friend) to ask him a lot of questions and to get his advice.
Geno2853
in
Advanced Prostate Cancer
7 months ago
ADT response and questions for MO
Hi, I am newish to this forum, still on a steep learning curve but I want to thank you for your contributions and discussions. This is my first time posting. My partner is 60 yrs old, as I understand it he had low PSA 3 yrs ago, not tested until Nov 2023, PSA50, stage 4, 1 met in 'sit' bone. Started
Hi, I am newish to this forum, still on a steep learning curve but I want to thank you for your contributions and discussions. This is my first time posting. My partner is 60 yrs old, as I understand it he had low PSA 3 yrs ago, not tested until Nov 2023, PSA50, stage 4, 1 met in 'sit' bone. Started
Lovecherries
in
Advanced Prostate Cancer
7 months ago
One questions doctors never seem to be able to answer is at what PSA level do you start to experience pain or physical problems?
One questions doctors never seem to be able to answer is at what PSA level do you start to experience pain or physical problems? If you have had surgery, Salvage Radiation, ADT, SRBT and then stopped ADT with a continuing rise in you PSA when did you start to have pain or physical problems?
One questions doctors never seem to be able to answer is at what PSA level do you start to experience pain or physical problems? If you have had surgery, Salvage Radiation, ADT, SRBT and then stopped ADT with a continuing rise in you PSA when did you start to have pain or physical problems?
Exrunner
in
Advanced Prostate Cancer
7 months ago
Enzalutamide vs Lupron Survival
This shows the main results of the EMBARK trial, comparing Metatasis Free Survival and PSA Recurrence Free Survival for three groups: Enzalutamide only, Lupron only, or combined Enzalutamide + Lupron. The best survivals were for the combination of Enzalutamide + Lupron. Enzalutamide is a 2nd generation
This shows the main results of the EMBARK trial, comparing Metatasis Free Survival and PSA Recurrence Free Survival for three groups: Enzalutamide only, Lupron only, or combined Enzalutamide + Lupron. The best survivals were for the combination of Enzalutamide + Lupron. Enzalutamide is a 2nd generation
janebob99
in
Prostate Cancer Network
7 months ago
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