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Benfotiamine In The Mix For PD Again?
The following new animal study (December 2023) suggests that the fat soluble form of vitamin B1, Benfotiamine, may also be suitable for PD : https://www.sciencedirect.com/science/article/abs/pii/S0014299923007483?via%3Dihub Here is a relevant study quote :
' The results demonstrated that treatment
The following new animal study (December 2023) suggests that the fat soluble form of vitamin B1, Benfotiamine, may also be suitable for PD : https://www.sciencedirect.com/science/article/abs/pii/S0014299923007483?via%3Dihub Here is a relevant study quote :
' The results demonstrated that treatment
chartist
in
Cure Parkinson's
7 months ago
How to use the prone position more efficiently
In a post on HealthUnlocked https://healthunlocked.com/rlsuk/posts/150167349/could-this-be-why-some-of-us-have-less-rls-while-sleeping-in-the-prone-position?responses=150181979&utm_source=notification&utm_medium=email&utm_campaign=email_individual_response , it's mentioned that the prone position is
In a post on HealthUnlocked https://healthunlocked.com/rlsuk/posts/150167349/could-this-be-why-some-of-us-have-less-rls-while-sleeping-in-the-prone-position?responses=150181979&utm_source=notification&utm_medium=email&utm_campaign=email_individual_response , it's mentioned that the prone position is
VladimirF
in
Restless Legs Syndrome
7 months ago
Suffering like hell since I tried to taper off a dopamin agonist
Hi all, From Feb to Aug, I succesfully tapered off Venlafaxine extended release that I had taken for 28 years. I had started taking this medicine when I was 20 after what was probably a post-traumatic stress episode diagnosed as 'fibromyalgia' by my doctors back at that time. I tried several times to
Hi all, From Feb to Aug, I succesfully tapered off Venlafaxine extended release that I had taken for 28 years. I had started taking this medicine when I was 20 after what was probably a post-traumatic stress episode diagnosed as 'fibromyalgia' by my doctors back at that time. I tried several times to
Mikatrap
in
Restless Legs Syndrome
7 months ago
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New therapies for RLS!! New research finally!
I have had RLS for 30 years, but when prescribed pramaprexole, of course, it made the monster worse. I did some research and there are two new therapies coming out. One is a new drug discovered by professor Dr. Stefan Clemens at Brody school of medicine...he discovered why augmentation happens...
I have had RLS for 30 years, but when prescribed pramaprexole, of course, it made the monster worse. I did some research and there are two new therapies coming out. One is a new drug discovered by professor Dr. Stefan Clemens at Brody school of medicine...he discovered why augmentation happens...
beartoothgirl406
in
Restless Legs Syndrome
7 months ago
AGA - American College of Gastroenterology Clinical Practice Guideline: Pharmacological Management of Chronic Idiopathic Constipation - 2023
https://journals.lww.com/ajg/fulltext/2023/06000/american_gastroenterological_association_american.13.aspx Abstract INTRODUCTION: Chronic idiopathic constipation (CIC) is a common disorder associated with significant impairment in quality of life. This clinical practice guideline, jointly developed
https://journals.lww.com/ajg/fulltext/2023/06000/american_gastroenterological_association_american.13.aspx Abstract INTRODUCTION: Chronic idiopathic constipation (CIC) is a common disorder associated with significant impairment in quality of life. This clinical practice guideline, jointly developed
Meleber
in
IBS Network
9 months ago
Vitamin B2 Deficiency Can Cause B6 Toxicity! PWP Are Commonly Deficient In B2.
Vitamin B6 recycling. Image credit https://www.frontiersin.org/files/Articles/276491/fneur-08-00333-HTML/image_m/fneur-08-00333-g002.jpg From: https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2017.00333/full Vitamin B6 is a coenzyme required for over 100 different biochemical transformations
Vitamin B6 recycling. Image credit https://www.frontiersin.org/files/Articles/276491/fneur-08-00333-HTML/image_m/fneur-08-00333-g002.jpg From: https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2017.00333/full Vitamin B6 is a coenzyme required for over 100 different biochemical transformations
park_bear
in
Cure Parkinson's
7 months ago
ADD Medication
I just had an interesting thought and inquiry about the relationship between specific neurotransmitters like dopamine and norepinephrine as a relates to very long chain, fatty acid metabolism, in peroxisomes. Surprisingly, there is a bit of a link, but it’s not clearly understood. My question is,
I just had an interesting thought and inquiry about the relationship between specific neurotransmitters like dopamine and norepinephrine as a relates to very long chain, fatty acid metabolism, in peroxisomes. Surprisingly, there is a bit of a link, but it’s not clearly understood. My question is,
bluejadedwho
in
AMN EASIER
8 months ago
t3 only treatment need advice
When i got hypo i figured out fast that t4 only only worsend everything. My doc added 10 t3 it was better but not optimal. She put me on 4 Grain NDT and i did well for 2 years. Then got one symptom and we played with NDT dosages lower, higher, brands and a combo with NDT plus 10 T3... I transitioned
When i got hypo i figured out fast that t4 only only worsend everything. My doc added 10 t3 it was better but not optimal. She put me on 4 Grain NDT and i did well for 2 years. Then got one symptom and we played with NDT dosages lower, higher, brands and a combo with NDT plus 10 T3... I transitioned
charley123
in
Thyroid UK
8 months ago
Potential therapeutic effects and pharmacological evidence of sinomenine in central nervous system disorders
Published online 2022 Sep 16, I realize it is a rat study, but it is sinomenine is used in Traditional Chinese Medicine. Pharmacological effects of sinomenine in Parkinson’s disease PD is a common neurodegenerative disorder characterized by progressive degeneration of dopaminergic neurons in the
Published online 2022 Sep 16, I realize it is a rat study, but it is sinomenine is used in Traditional Chinese Medicine. Pharmacological effects of sinomenine in Parkinson’s disease PD is a common neurodegenerative disorder characterized by progressive degeneration of dopaminergic neurons in the
Sydney75
in
Cure Parkinson's
8 months ago
Dyskinesia question
Is peak-dose dyskinesia essentially the same as wearing-off dyskinesia? In other words, are they both just a response to fluctuations in dopamine levels, and whether you experience one or the other (or both?) is just by chance, or is the difference in timing related to other factors? I'm sorry if that's
Is peak-dose dyskinesia essentially the same as wearing-off dyskinesia? In other words, are they both just a response to fluctuations in dopamine levels, and whether you experience one or the other (or both?) is just by chance, or is the difference in timing related to other factors? I'm sorry if that's
1LittleWillow
in
Cure Parkinson's
8 months ago
TTFD - I think I made a judgment error.
My Motion Disorder Specialist indicated that activity consumes dopamine. I have read that one way to increase production of dopamine is exercise. It is not unreasonable to conclude exercise can cause a demand of dopamine higher than your body can produce. I quit TTFD because of tremor (I was walking
My Motion Disorder Specialist indicated that activity consumes dopamine. I have read that one way to increase production of dopamine is exercise. It is not unreasonable to conclude exercise can cause a demand of dopamine higher than your body can produce. I quit TTFD because of tremor (I was walking
Gcf51
in
Cure Parkinson's
8 months ago
Parkinson's wife
My husband was diagnosed about 4 years ago though I suspect Parkinsons was developing long before that. Main problem - neither Sinemet or Madopar has any effect on bradykinesia or tremor (let alone the non motor symptoms)and increasing medication e.g. Neupro patch = rotigotine dopamine agonist only
My husband was diagnosed about 4 years ago though I suspect Parkinsons was developing long before that. Main problem - neither Sinemet or Madopar has any effect on bradykinesia or tremor (let alone the non motor symptoms)and increasing medication e.g. Neupro patch = rotigotine dopamine agonist only
veronicacoath
in
Cure Parkinson's
8 months ago
observations of progressing PD for PWP......Eyes
Eyes can tricky be things. As the eyes start to dry out the causal agent can be illusive and is often multifaceted. First the autonomic nervous system when in failure has been shown to reduce blinking. Try to train yourself to blink often of your own volition. The smooth muscles that intricately
Eyes can tricky be things. As the eyes start to dry out the causal agent can be illusive and is often multifaceted. First the autonomic nervous system when in failure has been shown to reduce blinking. Try to train yourself to blink often of your own volition. The smooth muscles that intricately
beehive23
in
Cure Parkinson's
8 months ago
Multiple mechanisms to clear a-synuclein with natural substances (in mice).
For informational purposes only Alpha Synuclein 1. INTRODUCTION: There are no effective treatments nor drugs available to modify disease progression
For informational purposes only Alpha Synuclein 1. INTRODUCTION: There are no effective treatments nor drugs available to modify disease progression
House2
in
Cure Parkinson's
8 months ago
Progression ,still no cofirmation
My wife is starting to deteriorate quite rapidly now, but no one in this area of Lincolnshire seems to know anything called PSP and trying to get the Specialists to acknowledge it seems impossible, but she is showing all the signs of PSP, Falls (backwards) difficulty swalloing, Slavering, running
My wife is starting to deteriorate quite rapidly now, but no one in this area of Lincolnshire seems to know anything called PSP and trying to get the Specialists to acknowledge it seems impossible, but she is showing all the signs of PSP, Falls (backwards) difficulty swalloing, Slavering, running
autex2000
in
PSP Association
8 months ago
Aspen Neuroscience Granted Fast Track Designation
FDA Grants Fast Track Designation to ANPD001, Autologous Investigational Cell Therapy for the Treatment of Parkinson’s Disease SAN DIEGO, Oct. 19, 2023 /PRNewswire/ — Aspen Neuroscience today announced that the U.S. Food and Drug Administration (FDA) has granted Fast Track Designation for ANPD001 for
FDA Grants Fast Track Designation to ANPD001, Autologous Investigational Cell Therapy for the Treatment of Parkinson’s Disease SAN DIEGO, Oct. 19, 2023 /PRNewswire/ — Aspen Neuroscience today announced that the U.S. Food and Drug Administration (FDA) has granted Fast Track Designation for ANPD001 for
redhawk1
in
Cure Parkinson's
8 months ago
Bayer Investing in New Cell Therapy Facility
Bayer Opens First Cell Therapy Manufacturing Facility to Advance Regenerative Medicines on a Global Scale $250 million (USD) plant will help produce transformational cell and gene therapies on a global scale Creating readiness for first production runs of potential commercial launches, including bemdaneprocel
Bayer Opens First Cell Therapy Manufacturing Facility to Advance Regenerative Medicines on a Global Scale $250 million (USD) plant will help produce transformational cell and gene therapies on a global scale Creating readiness for first production runs of potential commercial launches, including bemdaneprocel
redhawk1
in
Cure Parkinson's
8 months ago
DAWS success story?
Hi all, After a brutal stop of pramipexole (extended release) two weeks ago, predated by a tapering off Venlafaxine from March to August, I'm experiencing the hell of DAWS (Dopamine Agonist Withdrawal Syndrom). I'm now hospitalized in a neurology service, and they are giving me pregabalin, dypirimadole
Hi all, After a brutal stop of pramipexole (extended release) two weeks ago, predated by a tapering off Venlafaxine from March to August, I'm experiencing the hell of DAWS (Dopamine Agonist Withdrawal Syndrom). I'm now hospitalized in a neurology service, and they are giving me pregabalin, dypirimadole
Mikatrap
in
Restless Legs Syndrome
8 months ago
FINALLY found a scientific study that supports my theory about Brain Iron and Serum Iron. Finally!!!
First, the relevant quote from the article: “The serum iron concentration was significantly higher in the RLS group than in the control group, but remained within normal ranges in both groups. In this study, there was a significant correlation between serum and CSF iron concentrations, both in the RLS
First, the relevant quote from the article: “The serum iron concentration was significantly higher in the RLS group than in the control group, but remained within normal ranges in both groups. In this study, there was a significant correlation between serum and CSF iron concentrations, both in the RLS
DesertOasis
in
Restless Legs Syndrome
8 months ago
To Infuse or not to Infuse
I figured it was time to put the 45 infusion stories I could find all together so people can make an informed decision. Simply tap on the link and within a few lines you will know whether the person gave it a thumbs up or down. If you read the replies you may find more stories. I welcome anyone who
I figured it was time to put the 45 infusion stories I could find all together so people can make an informed decision. Simply tap on the link and within a few lines you will know whether the person gave it a thumbs up or down. If you read the replies you may find more stories. I welcome anyone who
DesertOasis
in
Restless Legs Syndrome
8 months ago
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