' The results demonstrated that treatment with BFT ameliorated MPTP-induced disorders in behavior, body balance, and dopamine levels in the mid-brain. Among the post-treated groups, a high dose of BFT was the most effective treatment. Mean values are indicated in ±SEM, n = 5***(p < 0.001) when compared with the vehicle control, n = 5 ### (p < 0.001) when compared with the disease control; (p < 0.001) when compared with the BFT per se; (p < 0.001) when compared with the low dose of BFT; (p < 0.001) when compared with the high dose of BFT. Our finding suggests that BFT contributed to superior antioxidant, and anti-inflammatory and could be a novel therapeutic method for PD management. In conclusion, BFT could be a potential drug candidate for curbing and preventing PD. '
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Sounds interesting. Has anyone tried it yet? I weigh about 75kg, so I would have to take 75x0.2grams = 15 grams of BFT (benfotiamine) daily. That's a lot! Or have I miscalculated? I once took 2.5 grams of B1 for a while - but didn't notice any changes.
There is an adjustment that must be applied to translate from animal models to humans. In the case of rats, divide the dosage by 8, for mice divide by 12.
Even when you convert the dose to human equivalent, the dose is still high compared to current human study dosing. The 100mg kg dose for humans would be approximately 16.2 mg/kg and double that for the 200 mg/kg dose or 32.4 mg/kg. I haven't seen human studies at this dose for benfotiamine yet.
If a person weighed 140 lb which converts to 63.5 kg at a dose of 16.2 mg/kg would that be 1028.7 mg? I want to be sure that I am doing the calculation on this correctly. Would that involve taking a little over 1000 mg and it appears that many of the benfotamine supplements are availabe in the 300 mg per capsule but some are other doses like 250 mg and 150 mg.
I have tried all forms of thiamine: thiamine HCl intramuscular injection, thiamine HCl pills at all doses, sublingual thiamine, alli-thiamine, benfothiamine, TTFD. All several times but always with much lower results than HDT STANDARD BY DR Costantini before HU, i.e. 2 intramuscular injections of thiamine HCL100 mg , twice a week with breaks of a few days in case of excess symptoms, which are only two or three as indicated in the medicine leaflet. In the last year, I have strictly returned to this protocol and I feel good. In my opinion, everything else is alteration that leads to greater complexity and confusion, but it still works because thiamine is always thiamine and always does the same things: a restorative effect on the cells of the nervous system at an energetic level and it work in synergy with levodopa.
This is my experience, since 2015 on thiamine hcl injections by dr C.
A potential treatment using an inexpensive vitamin. I dare say the idea will sink without trace given the complete absence of any profit potential. I wonder whether the solution to PD was always very simple but opportunities have been overlooked in the rush to find an complicated patentable novel therapy?
So I am on the sublingual B1 (refer to Daphne Bryan's book and study) Daphne seems to think u should not take Benefedimine (B1) with the sublingual form so after taking it for a couple months I threw I stopped taking it. This is all so confusing...It's hard to know what supplements u should and should not take ..ugh
I've heard that it can help (I take a small daily dose myself) but not as much as concentrating on lowering systemic inflammation especially from foods and inceasing antioxidant intake.
Wish there were a study of TTFD. This one mentions 100mg a day of fursultiamine (a name for TTFD) in treatment for Alzheimer’s. (I overdose on 50mg.) ncbi.nlm.nih.gov/pmc/articl...
I am currently seeing some positive results with 5mg ALINAMIN F and 1000mg B1 hcl oral.
That article also mentions a human study on benfotiamine...
A randomised controlled trial supplementing benfotiamine (600mg/day for 1 year) reported improved cognitive function in AD patients, and a study supplementing fursultiamine (100mg/day for 3 months) resulted in improved cognitive function in cases with mild AD.
Drug company says: Fursultiamine is primarily used as a cognitive enhancer, particularly in the treatment of cognitive impairment associated with dementia and Alzheimer's disease. It is also used in the treatment of fatigue, depression, anxiety, and Parkinson's disease. fengchengroup.com/pharmaceu...
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