Benfotiamine In The Mix For PD Again?

[chartist]

The following new animal study (December 2023) suggests that the fat soluble form of vitamin B1, Benfotiamine, may also be suitable for PD :

sciencedirect.com/science/a...

Here is a relevant study quote :

' The results demonstrated that treatment with BFT ameliorated MPTP-induced disorders in behavior, body balance, and dopamine levels in the mid-brain. Among the post-treated groups, a high dose of BFT was the most effective treatment. Mean values are indicated in ±SEM, n = 5***(p < 0.001) when compared with the vehicle control, n = 5 ### (p < 0.001) when compared with the disease control; (p < 0.001) when compared with the BFT per se; (p < 0.001) when compared with the low dose of BFT; (p < 0.001) when compared with the high dose of BFT. Our finding suggests that BFT contributed to superior antioxidant, and anti-inflammatory and could be a novel therapeutic method for PD management. In conclusion, BFT could be a potential drug candidate for curbing and preventing PD. '

Art

[PDTom]

Sounds interesting. Has anyone tried it yet? I weigh about 75kg, so I would have to take 75x0.2grams = 15 grams of BFT (benfotiamine) daily. That's a lot! Or have I miscalculated? I once took 2.5 grams of B1 for a while - but didn't notice any changes.

[park_bear in reply to PDTom]

There is an adjustment that must be applied to translate from animal models to humans. In the case of rats, divide the dosage by 8, for mice divide by 12.

[Ghmac in reply to park_bear]

Dang PB you know so much....

[chartist in reply to PDTom]

Even when you convert the dose to human equivalent, the dose is still high compared to current human study dosing. The 100mg kg dose for humans would be approximately 16.2 mg/kg and double that for the 200 mg/kg dose or 32.4 mg/kg. I haven't seen human studies at this dose for benfotiamine yet.

Art

[Boscoejean in reply to chartist]

If a person weighed 140 lb which converts to 63.5 kg at a dose of 16.2 mg/kg would that be 1028.7 mg? I want to be sure that I am doing the calculation on this correctly. Would that involve taking a little over 1000 mg and it appears that many of the benfotamine supplements are availabe in the 300 mg per capsule but some are other doses like 250 mg and 150 mg.

[chartist in reply to Boscoejean]

Yes, that would be correct. Yes also on 300 mg capsules. Current human studies generally use 600 mg/day in two divided doses of 300 mg each.

Art

[Lolo2022 in reply to chartist]

our friend Gioc has tried Benfotiamine without success

[Gioc in reply to Lolo2022]

hi Lolo ,

I have tried all forms of thiamine: thiamine HCl intramuscular injection, thiamine HCl pills at all doses, sublingual thiamine, alli-thiamine, benfothiamine, TTFD. All several times but always with much lower results than HDT STANDARD BY DR Costantini before HU, i.e. 2 intramuscular injections of thiamine HCL100 mg , twice a week with breaks of a few days in case of excess symptoms, which are only two or three as indicated in the medicine leaflet. In the last year, I have strictly returned to this protocol and I feel good. In my opinion, everything else is alteration that leads to greater complexity and confusion, but it still works because thiamine is always thiamine and always does the same things: a restorative effect on the cells of the nervous system at an energetic level and it work in synergy with levodopa.

This is my experience, since 2015 on thiamine hcl injections by dr C.

Greetings from Italy .

Gio

I ❤️trees ….(mulberry)

[JayPwP]

I feel the issue is if excess is taken then it will not be flushed out by drinking water, as can be done with B1 HCL

[Buckholt]

A potential treatment using an inexpensive vitamin. I dare say the idea will sink without trace given the complete absence of any profit potential. I wonder whether the solution to PD was always very simple but opportunities have been overlooked in the rush to find an complicated patentable novel therapy?

[Lyrics19]

So I am on the sublingual B1 (refer to Daphne Bryan's book and study) Daphne seems to think u should not take Benefedimine (B1) with the sublingual form so after taking it for a couple months I threw I stopped taking it. This is all so confusing...It's hard to know what supplements u should and should not take ..ugh

[Lyrics19]

Please read my post below about taking sublingual B1 with Benefedimine....

[Boscoejean in reply to Lyrics19]

benfotiamine?

[Boscoejean]

was the benfotiamine administered intranasally to the rodents

[chartist in reply to Boscoejean]

It was oral dosing that was used in the study.

Art

[Eryl]

I've heard that it can help (I take a small daily dose myself) but not as much as concentrating on lowering systemic inflammation especially from foods and inceasing antioxidant intake.

[Gcf51]

Wish there were a study of TTFD. This one mentions 100mg a day of fursultiamine (a name for TTFD) in treatment for Alzheimer’s. (I overdose on 50mg.) ncbi.nlm.nih.gov/pmc/articl...

I am currently seeing some positive results with 5mg ALINAMIN F and 1000mg B1 hcl oral.

[Gcf51 in reply to Gcf51]

That article also mentions a human study on benfotiamine...

A randomised controlled trial supplementing benfotiamine (600mg/day for 1 year) reported improved cognitive function in AD patients, and a study supplementing fursultiamine (100mg/day for 3 months) resulted in improved cognitive function in cases with mild AD.

[Gcf51 in reply to Gcf51]

Drug company says: Fursultiamine is primarily used as a cognitive enhancer, particularly in the treatment of cognitive impairment associated with dementia and Alzheimer's disease. It is also used in the treatment of fatigue, depression, anxiety, and Parkinson's disease. fengchengroup.com/pharmaceu...

Where are studies on Parkinson's?