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Dividing the dose
There was a talk about dopamine levels and tolerance. How to avoid this by intermittent dosing. How the brain responds more strongly to surprise levels of dopamine. I've been trying this by dividing the dose of 3 madopar every 4 hours into 2s and 1s. And sometimes taking 2nd dose early before 1st
There was a talk about dopamine levels and tolerance. How to avoid this by intermittent dosing. How the brain responds more strongly to surprise levels of dopamine. I've been trying this by dividing the dose of 3 madopar every 4 hours into 2s and 1s. And sometimes taking 2nd dose early before 1st
Johnmo
in
Cure Parkinson's
2 years ago
dopamine
https://healthunlocked.com/cure-parkinsons/posts/write
https://healthunlocked.com/cure-parkinsons/posts/write
kaypeeoh
in
Cure Parkinson's
2 years ago
Recent preprint by Jeff Kordower et al. suggests tau (not alpha-syn) is the initial pathology in nigrostriatal dopamine neuron degeneration
"These data should change our thinking of PD pathology and therapies directed towards reducing pathological tau might be a better strategy than those directed at α-syn." Research paper preprint (not yet peer-reviewed): Is Tau the Initial Pathology in Dopaminergic Nigrostriatal Degeneration? Studies
"These data should change our thinking of PD pathology and therapies directed towards reducing pathological tau might be a better strategy than those directed at α-syn." Research paper preprint (not yet peer-reviewed): Is Tau the Initial Pathology in Dopaminergic Nigrostriatal Degeneration? Studies
jeffreyn
in
Cure Parkinson's
2 years ago
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Depression
I wrote the following in response to a member on this sight and thought I would share with everyone. "I am taking the very small amount of Bupropian. I was prescribed 300mg daily but if I go over 12 mg the anxiety and headaches are unbearable. I was on prozac for 25 years. For me it was calming and
I wrote the following in response to a member on this sight and thought I would share with everyone. "I am taking the very small amount of Bupropian. I was prescribed 300mg daily but if I go over 12 mg the anxiety and headaches are unbearable. I was on prozac for 25 years. For me it was calming and
Birdland
in
Restless Legs Syndrome
2 years ago
B12-supplement causing restlessness, brain fog, anhedonia and sexual dysfunction
Hi! I made a post a while ago about reaction to B12. I still keep reacting badly. I dont understand what is happening and How.I keep getting restless and have bad sleep. Also get bad brain fog, concentration and anhedonia. The new symtom is sexual dysfunction.I had taken small doses B12 because of
Hi! I made a post a while ago about reaction to B12. I still keep reacting badly. I dont understand what is happening and How.I keep getting restless and have bad sleep. Also get bad brain fog, concentration and anhedonia. The new symtom is sexual dysfunction.I had taken small doses B12 because of
Sofa00
in
Pernicious Anaemia Society
2 years ago
Creativity as therapy?
This is a question from a forum newbie, I wonder if any others have found arts and crafts can help with RLS. I've had RLS for many years, Ropinirole lets me sleep (been taking for years; lucky, no augmentation yet) but is no help during the day. I find if I do painting, drawing, mosaic, sewing... even
This is a question from a forum newbie, I wonder if any others have found arts and crafts can help with RLS. I've had RLS for many years, Ropinirole lets me sleep (been taking for years; lucky, no augmentation yet) but is no help during the day. I find if I do painting, drawing, mosaic, sewing... even
Ouchagain
in
Restless Legs Syndrome
2 years ago
Has anyone taken the GeneSight test? What was your experience, was it helpful for your medication management?
I just received a copy of my GeneSight test results in advance of an appointment with my psychiatrist. I have some preliminary ideas as to how to interpret and use this info. Some background: I have Bipolar II and ADHD-C. I've been on 18mg of Concerta since January 2021, until the last couple of months
I just received a copy of my GeneSight test results in advance of an appointment with my psychiatrist. I have some preliminary ideas as to how to interpret and use this info. Some background: I have Bipolar II and ADHD-C. I've been on 18mg of Concerta since January 2021, until the last couple of months
Great_Artiste
in
CHADD's Adult ADHD Support
2 years ago
what else is deficient in PD? Norepinephrine?
should PD patients be supplementing other chemicals, neurotransmitters such as norepinephrine (NE) as well as dopamine? How would one supplement NE?
should PD patients be supplementing other chemicals, neurotransmitters such as norepinephrine (NE) as well as dopamine? How would one supplement NE?
Usufruct
in
Cure Parkinson's
2 years ago
If you're suffering from RLS, ead this. I suffered for 20 yrs before finding a solution.
I've dealt with symptoms of RLS for 20yrs & it's the worst torture I've ever endured. I got tired of masking my symptoms and never finding the underlying cause or a cure. After years or research I came across an article that gave me all the answers I'd been seeking and my life hasnt been the same.
I've dealt with symptoms of RLS for 20yrs & it's the worst torture I've ever endured. I got tired of masking my symptoms and never finding the underlying cause or a cure. After years or research I came across an article that gave me all the answers I'd been seeking and my life hasnt been the same.
Caruso1us
in
Restless Legs Syndrome
2 years ago
ECOPIPAM for AugmentationUPDATE
Some of you may remember that small trials of Ecopipam, a D1 antagonist were carried out by William Ondo inTexas in 2019 and showed encouraging initial results in treating Augmentation on Dopamine Agonists. https://www.tandfonline.com/doi/full/10.1080/00207454.2020.1838515 Dr Stefan Clements at
Some of you may remember that small trials of Ecopipam, a D1 antagonist were carried out by William Ondo inTexas in 2019 and showed encouraging initial results in treating Augmentation on Dopamine Agonists. https://www.tandfonline.com/doi/full/10.1080/00207454.2020.1838515 Dr Stefan Clements at
Joolsg
in
Restless Legs Syndrome
2 years ago
Cerebral dopamine neurotrophic factor protects and repairs dopamine neurons by novel mechanism
Since ER stress is thought to be one of the pathophysiological mechanisms contributing to the dopaminergic degeneration in PD, CDNF, and its small-molecule derivatives that are under development may provide useful tools for experimental medicine and future therapies for the treatment of PD and other
Since ER stress is thought to be one of the pathophysiological mechanisms contributing to the dopaminergic degeneration in PD, CDNF, and its small-molecule derivatives that are under development may provide useful tools for experimental medicine and future therapies for the treatment of PD and other
House2
in
Cure Parkinson's
2 years ago
Phenylethylamine is NOT Palmitoylethanolamide! They are both called PEA. I take Palmitoylethanolamide
It is really unfortunate that both Phenylethylamine and Palmitoylethanolamide are called PEA as they are totally different supplements. [u]
I take Palmitoylethanolamide.
[/u] A quick Google of Phenylethylamine +Parkinson's finds: Contribution of β-phenethylamine, a component of chocolate and wine
It is really unfortunate that both Phenylethylamine and Palmitoylethanolamide are called PEA as they are totally different supplements. [u]
I take Palmitoylethanolamide.
[/u] A quick Google of Phenylethylamine +Parkinson's finds: Contribution of β-phenethylamine, a component of chocolate and wine
Bolt_Upright
in
Cure Parkinson's
2 years ago
'Too much' brain calcium may cause Parkinson's
Before my diagnosis I always had Low level of Vitamin D (like many of Pwpd) and High level of PTH (Parathyroid hormone) but normal calcium level. This study is from 2018 but Calcium concept has been intriguing me for years specially after I was diagnosed with Idiopathic Parkinson's disease.
Before my diagnosis I always had Low level of Vitamin D (like many of Pwpd) and High level of PTH (Parathyroid hormone) but normal calcium level. This study is from 2018 but Calcium concept has been intriguing me for years specially after I was diagnosed with Idiopathic Parkinson's disease.
Kia17
in
Cure Parkinson's
2 years ago
PS128 Again in the News
https://parkinsonsnewstoday.com/sponsored-content/3-reasons-to-consider-a-daily-probiotic-supplement-for-parkinsons/ 1/ Gut health probiotics for constipation Constipation and other gastrointestinal problems are very common non-motor symptoms of PD. Fortunately, many strains of probiotic bacteria can
https://parkinsonsnewstoday.com/sponsored-content/3-reasons-to-consider-a-daily-probiotic-supplement-for-parkinsons/ 1/ Gut health probiotics for constipation Constipation and other gastrointestinal problems are very common non-motor symptoms of PD. Fortunately, many strains of probiotic bacteria can
Baron1
in
Cure Parkinson's
2 years ago
FUS technical explanation
I'll attach few pictures about FUS and also my EEG. See the 1st picture. The loss of dopamine in BG produces electrical signals disturbances in the Thalamus which are causing the PD symptoms. The dopamine is coming from Substantia Niagra (naturally) or carbidova/levodoba (artificially). When the BG
I'll attach few pictures about FUS and also my EEG. See the 1st picture. The loss of dopamine in BG produces electrical signals disturbances in the Thalamus which are causing the PD symptoms. The dopamine is coming from Substantia Niagra (naturally) or carbidova/levodoba (artificially). When the BG
ion_ion
in
Cure Parkinson's
2 years ago
Melatonin for PD
Melatonin (5-methoxy-N-acetyltryptamine): powerful antioxidant that treats abnormalities in sleep-wake cycle, jet lag, cancer, and Parkinson’s disease. Epileptic children have a higher incidence of sleep problems; epilepsy is exacerbated by sleep deprivation. Melatonin has antiepileptic activity. Mechanism
Melatonin (5-methoxy-N-acetyltryptamine): powerful antioxidant that treats abnormalities in sleep-wake cycle, jet lag, cancer, and Parkinson’s disease. Epileptic children have a higher incidence of sleep problems; epilepsy is exacerbated by sleep deprivation. Melatonin has antiepileptic activity. Mechanism
Farooqji
in
Cure Parkinson's
2 years ago
Slowing the Progression of PD (adapted from a book)
“Strength of body, strength of mind and soul is vitally important. These things are important for anyone in any situation, but especially for those of us who find ourselves fighting this weakening disease. I could give in to this tomorrow and just stop trying to live a normal life, and I would probably
“Strength of body, strength of mind and soul is vitally important. These things are important for anyone in any situation, but especially for those of us who find ourselves fighting this weakening disease. I could give in to this tomorrow and just stop trying to live a normal life, and I would probably
Farooqji
in
Cure Parkinson's
2 years ago
Parkinson’s and Protein
“I explored diets and after realizing I was generally doing worse if I ate a lot of meat, I looked into vegetarian diets…. What a difference it makes for me.” —GAIL J., PWP You may have heard about protein being a no-no in the Parkinson’s diet. This is only partially true. The problem is that because
“I explored diets and after realizing I was generally doing worse if I ate a lot of meat, I looked into vegetarian diets…. What a difference it makes for me.” —GAIL J., PWP You may have heard about protein being a no-no in the Parkinson’s diet. This is only partially true. The problem is that because
Farooqji
in
Cure Parkinson's
2 years ago
PD or FND?
Check out FND: https://en.m.wikipedia.org/wiki/Functional_neurologic_disorder Symptoms sound just like PD. It's it possible a person told they have PD actually had FND. It's important because FND is triggered by stress, not some still poorly understood mechanism with dopamine. Anyone hear of this?
Check out FND: https://en.m.wikipedia.org/wiki/Functional_neurologic_disorder Symptoms sound just like PD. It's it possible a person told they have PD actually had FND. It's important because FND is triggered by stress, not some still poorly understood mechanism with dopamine. Anyone hear of this?
stocktiki
in
Cure Parkinson's
2 years ago
Glutathione therapy
Glutathione is an antioxidant that assists in ridding the brain of dangerous free radicals. People with PD have low levels of glutathi-one, specifically in the substantia nigra, the area in the brain where dopamine is lost. This can mean that their cells die faster and the disease progresses more quickly
Glutathione is an antioxidant that assists in ridding the brain of dangerous free radicals. People with PD have low levels of glutathi-one, specifically in the substantia nigra, the area in the brain where dopamine is lost. This can mean that their cells die faster and the disease progresses more quickly
Farooqji
in
Cure Parkinson's
2 years ago
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