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Enzalutamide Plus 5-Alpha Reductase Inhibitors for Castrate-Sensitive Prostate Cancer
Phase II trial exploring the combination of enzalutamide with five alpha-reductase inhibitors (ARIs) for castrate-sensitive prostate cancer. Driven by observations from geriatric oncology, the study seeks alternatives to androgen deprivation therapy (ADT) for older, frail men who struggle with its side
Phase II trial exploring the combination of enzalutamide with five alpha-reductase inhibitors (ARIs) for castrate-sensitive prostate cancer. Driven by observations from geriatric oncology, the study seeks alternatives to androgen deprivation therapy (ADT) for older, frail men who struggle with its side
God_Loves_Me
in
Advanced Prostate Cancer
2 months ago
Signifficant PSA LEVELS
I'm an 81 year old man who has had an enlarged prostate for several months. PSA tests levels 9.1 and 8.1 (several months apart). My Father died of prostate cancer, which had spread to other parts of his body. Follwing a Digital Anal test, my prostate was reported as "smoothly enlarged and sulcus palpable
I'm an 81 year old man who has had an enlarged prostate for several months. PSA tests levels 9.1 and 8.1 (several months apart). My Father died of prostate cancer, which had spread to other parts of his body. Follwing a Digital Anal test, my prostate was reported as "smoothly enlarged and sulcus palpable
apttony
in
Prostate Cancer Network
2 months ago
Does PSA drop after starting ADT tell us anything?
My husband started Firmagon shots a month ago. Before starting his PSA was 5.9. It was tested a few days ago and it’s 1.4 now. Does this tell us anything of any significance? Thanks!
My husband started Firmagon shots a month ago. Before starting his PSA was 5.9. It was tested a few days ago and it’s 1.4 now. Does this tell us anything of any significance? Thanks!
EvFC
in
Advanced Prostate Cancer
2 months ago
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Terrible sleep issues
So now I’m 10+ weeks into treatment consisting of Lupron+Abiraterrone and have completed 5 of 20 radiation sessions. In many ways things seem to be going very well. My PSA numbers have gone from 8.4 to .2 and still falling. My side effects have been minimal , only lately have I seen some mild hot
So now I’m 10+ weeks into treatment consisting of Lupron+Abiraterrone and have completed 5 of 20 radiation sessions. In many ways things seem to be going very well. My PSA numbers have gone from 8.4 to .2 and still falling. My side effects have been minimal , only lately have I seen some mild hot
Willie51
in
Prostate Cancer And Gay Men
2 months ago
Why is my RO changing from Degerelix to Lupron after a month?
my husband started ADT treatment and RO informed him that after a month he will switch to Lupron. Is there a reason why he is doing this? As Lupron I read causes depression, anxiety. And if hopefully Degerelix works why change it? Can we request he not ? TIA.
my husband started ADT treatment and RO informed him that after a month he will switch to Lupron. Is there a reason why he is doing this? As Lupron I read causes depression, anxiety. And if hopefully Degerelix works why change it? Can we request he not ? TIA.
SherryKahn
in
Advanced Prostate Cancer
2 months ago
Interpreting blood tests
I've been on ADT for 4 months in preparation for RT and then HDR BT. I have localised G8 with an initial PSA of 8.1 Prior to commencing ADT, my PSA inexplicably dropped to 4.94 but then rose to 5.37 within 2 months. Anyway, here are my test results before starting ADT; These are Aussie measurements
I've been on ADT for 4 months in preparation for RT and then HDR BT. I have localised G8 with an initial PSA of 8.1 Prior to commencing ADT, my PSA inexplicably dropped to 4.94 but then rose to 5.37 within 2 months. Anyway, here are my test results before starting ADT; These are Aussie measurements
Mike58
in
Advanced Prostate Cancer
2 months ago
Finally got a diagnosis of Endometriosis today
I've been on such a journey with my pelvic pain. I'm 50 and I had a hysterectomy 4 months ago for fibroids. A laparoscopy ruled out Endo last year. I was pain free for the first time in months. I started hrt and my original pains 6 weeks ago came back with a vengeance just like they did last year when
I've been on such a journey with my pelvic pain. I'm 50 and I had a hysterectomy 4 months ago for fibroids. A laparoscopy ruled out Endo last year. I was pain free for the first time in months. I started hrt and my original pains 6 weeks ago came back with a vengeance just like they did last year when
Mindfullness4791
in
Endometriosis UK
2 months ago
Thank you
I stumbled on this forum about 15 to 18 months ago. Just to show you how little I knew and how clueless I was I had no idea there was run of the mill prostrate cancer or an advanced form. I just knew I had prostrate cancer and needed to make a decision - surgery or radiation. I stumbled through this
I stumbled on this forum about 15 to 18 months ago. Just to show you how little I knew and how clueless I was I had no idea there was run of the mill prostrate cancer or an advanced form. I just knew I had prostrate cancer and needed to make a decision - surgery or radiation. I stumbled through this
Mgtd
in
Advanced Prostate Cancer
2 months ago
False positives
All is not cancer that lights up on the scans! In February, a PSMA PET/CT found nothing abnormal, just a minimal PSMA signal from rib 10 right. But the NaF PET/CT: "On the right, rib 10 has abnormal PET uptake (SUVmax 27.3). The same rib uptake can be seen in previous bone scintigraphy and as a minimal
All is not cancer that lights up on the scans! In February, a PSMA PET/CT found nothing abnormal, just a minimal PSMA signal from rib 10 right. But the NaF PET/CT: "On the right, rib 10 has abnormal PET uptake (SUVmax 27.3). The same rib uptake can be seen in previous bone scintigraphy and as a minimal
Purple-Bike
in
Advanced Prostate Cancer
2 months ago
Anyone find cold plunge or sauna helpful?
I'm six weeks in on ADT. Working to stay ahead of fatigue with resistance training and weighted vest walking as I gear up for radiation and chemo in the next few months. Anyone done any cold plunge or sauna to help battle side effects or get better sleep? What was your experience?
I'm six weeks in on ADT. Working to stay ahead of fatigue with resistance training and weighted vest walking as I gear up for radiation and chemo in the next few months. Anyone done any cold plunge or sauna to help battle side effects or get better sleep? What was your experience?
PuraVida2024
in
Advanced Prostate Cancer
2 months ago
"Deluxe Treatment" Anything else?
Hi all this is my first post. I have just entered my story in my profile. I was diagnosed and treated in 2021 and had immediate recurrence with stage 4 Olig Metastatic in 1 pelvic node and left hip. Had an excellent response to triplet therapy and was very happy with my treatment plan as I new next to
Hi all this is my first post. I have just entered my story in my profile. I was diagnosed and treated in 2021 and had immediate recurrence with stage 4 Olig Metastatic in 1 pelvic node and left hip. Had an excellent response to triplet therapy and was very happy with my treatment plan as I new next to
InqPers
in
Advanced Prostate Cancer
2 months ago
ALT and AST levels
Hi all! I'll begin by thanking everyone on this site for the invaluable information I've found here. I'm Gleason 9, very high risk, localized pca. In Jan/Feb I rec'd 5 treatments of SBRT and have been on Lupron and Abiraterone/prednisone for the past 7 months. Just had labs done, and psa is at 0.1. The
Hi all! I'll begin by thanking everyone on this site for the invaluable information I've found here. I'm Gleason 9, very high risk, localized pca. In Jan/Feb I rec'd 5 treatments of SBRT and have been on Lupron and Abiraterone/prednisone for the past 7 months. Just had labs done, and psa is at 0.1. The
Quarky
in
Advanced Prostate Cancer
2 months ago
diagnosed yesterday with Cystoce
For a while I have been suffering with bladder issues, always feeling I needed to go but can never fulfill emptying bladder so constantly in and out of bathroom. After an internal examination Consultant confirmed cervix looked healthy and that I had a prolapsed bladder which was also pushing down on
For a while I have been suffering with bladder issues, always feeling I needed to go but can never fulfill emptying bladder so constantly in and out of bathroom. After an internal examination Consultant confirmed cervix looked healthy and that I had a prolapsed bladder which was also pushing down on
JayceeJC
in
Pelvic Pain Support Network
2 months ago
intraductal carcinoma
My husband's biopsy was reread by MSK and one of the cores said the following, "Focally suspicious for intraductal carcinoma (separate core)." He has been diagnosed with stage 4A prostate cancer with one pelvic lymph node involvement that I have written about here. Moving ahead with ADT then internal
My husband's biopsy was reread by MSK and one of the cores said the following, "Focally suspicious for intraductal carcinoma (separate core)." He has been diagnosed with stage 4A prostate cancer with one pelvic lymph node involvement that I have written about here. Moving ahead with ADT then internal
SherryKahn
in
Advanced Prostate Cancer
2 months ago
Recommended Reading
I know this forum is primarily for those with advanced PCA, yet I regularly see posts by those who've only recently discovered the disease and are not in such adavanced stages, being treated only with 1st-generation ADT. Thus, as a nearly 20-year survivor of PCa (first discovered in 2005) and 10-year
I know this forum is primarily for those with advanced PCA, yet I regularly see posts by those who've only recently discovered the disease and are not in such adavanced stages, being treated only with 1st-generation ADT. Thus, as a nearly 20-year survivor of PCa (first discovered in 2005) and 10-year
bluesnjazz
in
Advanced Prostate Cancer
3 months ago
hypothyroidism
I am trying to make a change in thyroid medication.....I was trying change over to a natural thyroid and stop my Armour thyroid 90 mcg I was doing good until last month ....got very tired, heart palpitations , joint pain ect.... been trying to get thyroid tested but could not get doctors to do ( long
I am trying to make a change in thyroid medication.....I was trying change over to a natural thyroid and stop my Armour thyroid 90 mcg I was doing good until last month ....got very tired, heart palpitations , joint pain ect.... been trying to get thyroid tested but could not get doctors to do ( long
Spencer7
in
Thyroid UK
6 months ago
Anyone felt as if drunk while on Relugovix?
After 13 months of ADT vacation, I've gone back on ADT last week. This time I am on Relugovix (Orgovyx) instead of Lupron. Since I exercise pretty much everyday, even upping my training a little more on the cardio side of late, I think I am doing not too bad against the fatigue from the ADT. Then
After 13 months of ADT vacation, I've gone back on ADT last week. This time I am on Relugovix (Orgovyx) instead of Lupron. Since I exercise pretty much everyday, even upping my training a little more on the cardio side of late, I think I am doing not too bad against the fatigue from the ADT. Then
Mascouche
in
Advanced Prostate Cancer
3 months ago
Provenge immunotherapy
After 5.5 years on Lupron (no Zytiga, Xtandi, Daro, etc.), my PSA hit its highest points ever (1.92), although I'm still not 2 points above my lowest reading of 0.5 (only one of those). I'm metastatic and was at diagnosis, so still have prostate. I've been researching Provenge a bit, and understand that
After 5.5 years on Lupron (no Zytiga, Xtandi, Daro, etc.), my PSA hit its highest points ever (1.92), although I'm still not 2 points above my lowest reading of 0.5 (only one of those). I'm metastatic and was at diagnosis, so still have prostate. I've been researching Provenge a bit, and understand that
dhccpa
in
Advanced Prostate Cancer
3 months ago
Difficulty walking. Would pred boost help.
Hello. I haven’t posted lately. I have been diligently tapering .5 mg every 5 to 6 weeks, previously on 9 years of pred with flare and set backs along the way including Avascular necrosis, osteoarthritis DDD to name a few. I am waiting for pain clinic spine injections and a referral to my back Dr. because
Hello. I haven’t posted lately. I have been diligently tapering .5 mg every 5 to 6 weeks, previously on 9 years of pred with flare and set backs along the way including Avascular necrosis, osteoarthritis DDD to name a few. I am waiting for pain clinic spine injections and a referral to my back Dr. because
Nightingales
in
PMRGCAuk
3 months ago
early new diagnosed low volume metastatic disease and treatment comparisons
https://www.urologytimes.com/view/meta-analysis-indicates-benefit-of-combination-treatment-approach-in-mhspc Recently discussed here was whether low volume metastatic state was a thing, and whether metastatic directed treatment is proven science yet and this interview just came out highlighting a meta
https://www.urologytimes.com/view/meta-analysis-indicates-benefit-of-combination-treatment-approach-in-mhspc Recently discussed here was whether low volume metastatic state was a thing, and whether metastatic directed treatment is proven science yet and this interview just came out highlighting a meta
street-air
in
Advanced Prostate Cancer
3 months ago
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