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Docxtel triple therapy?
Thank you for sharing your thoughts. My dad--81, advanced metastatic castrate resistant Diagnosed at 79 with stage 4 met 8 bones, including skull, no Gleason, never even saw a urologist. Diagnosed in ER and sent straight to the oncologist and palliative care doctor. PSA initially at 137 Lupron
Thank you for sharing your thoughts. My dad--81, advanced metastatic castrate resistant Diagnosed at 79 with stage 4 met 8 bones, including skull, no Gleason, never even saw a urologist. Diagnosed in ER and sent straight to the oncologist and palliative care doctor. PSA initially at 137 Lupron
lgutman
in
Advanced Prostate Cancer
7 months ago
Update and question about Olaparib
Its my 60th birthday today! Glad to still be here! CT scan was stable but CA15 continues to rise on Trodelvy. CA15 is an important indicator for me. This info plus a comprehensive new Gardian DNA blood genetic test showed us some new options based on my mutations/bio markers (I am an architect so firgive
Its my 60th birthday today! Glad to still be here! CT scan was stable but CA15 continues to rise on Trodelvy. CA15 is an important indicator for me. This info plus a comprehensive new Gardian DNA blood genetic test showed us some new options based on my mutations/bio markers (I am an architect so firgive
Iwasborntodothis
in
SHARE Metastatic Breast Cancer
3 months ago
PSA reduction after Estrogen Patch Therapy
Here's a revised plot of PSA reduction due to castration from Estrogen Patch therapy. The previous version had the wrong time scale. That has been corrected in this version. The total time is 3 months, after which the PSA and testosterone both flatten out versus time. I've also added the reference
Here's a revised plot of PSA reduction due to castration from Estrogen Patch therapy. The previous version had the wrong time scale. That has been corrected in this version. The total time is 3 months, after which the PSA and testosterone both flatten out versus time. I've also added the reference
janebob99
in
Advanced Prostate Cancer
7 months ago
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PSA reduction by Estrogen Patch (revised)
Here's a revised plot of PSA reduction due to castration from Estrogen Patch therapy. The previous version had the wrong time scale. That has been corrected in this version. The total time is 3 months, after which the PSA and testosterone both flattened out versus time. I've also added the reference
Here's a revised plot of PSA reduction due to castration from Estrogen Patch therapy. The previous version had the wrong time scale. That has been corrected in this version. The total time is 3 months, after which the PSA and testosterone both flattened out versus time. I've also added the reference
janebob99
in
Prostate Cancer Network
7 months ago
Malecare newsletter reports Finish study glucocorticoids (e.g. prednisone, prednisolone, dexamethasone) can lead to castrate resistance
“However, recent studies have shown that the glucocorticoid receptor also has an oncogenic, or cancer-promoting, effect in cancers like breast and prostate cancer. In prostate cancer, the glucocorticoid receptor can replace the activity of the androgen receptor, which is main oncogenic factor in this
“However, recent studies have shown that the glucocorticoid receptor also has an oncogenic, or cancer-promoting, effect in cancers like breast and prostate cancer. In prostate cancer, the glucocorticoid receptor can replace the activity of the androgen receptor, which is main oncogenic factor in this
Graham49
in
Advanced Prostate Cancer
6 months ago
Hi everyone, I was diagnosed with Breast Cancer. ER7, PGR4, HER2 neg (and NPI 3.44 what ever this is).
I discovered a lump on Christmas Day, was seen at the hospital on the 10th of January. January 23rd the lump was removed along with 4 lymph nodes. My question is I am on Anastrazole 1mg , Levothyroxine 25mg (thyroid decided to pack in) and Atorovastatin 40mg. Can I take any of these pills at the same
I discovered a lump on Christmas Day, was seen at the hospital on the 10th of January. January 23rd the lump was removed along with 4 lymph nodes. My question is I am on Anastrazole 1mg , Levothyroxine 25mg (thyroid decided to pack in) and Atorovastatin 40mg. Can I take any of these pills at the same
sas65
in
SHARE Breast Cancer Support
7 months ago
Dad's PSA now 1800..nothing works..Is this the end??
Hey all, It pains me to write this as I'm probably scared to hear the truth. I've posted a few times, but this time, it's different. Dad was in hospital for a spinal cord compression - new activity on c3, new mets to spine and PSA soaring to 1800. Those dreaded words, "all options have been exhausted
Hey all, It pains me to write this as I'm probably scared to hear the truth. I've posted a few times, but this time, it's different. Dad was in hospital for a spinal cord compression - new activity on c3, new mets to spine and PSA soaring to 1800. Those dreaded words, "all options have been exhausted
kikinini
in
Advanced Prostate Cancer
3 months ago
The De-Escalate Trial: Intermittently Stopping Prostate Cancer Treatments to Improve QoL
as the title says: https://www.urotoday.com/video-lectures/asco-gu-2024/video/mediaitem/3875-the-de-escalate-trial-intermittently-stopping-prostate-cancer-treatments-to-improve-quality-of-life-guillaume-grisay.html
as the title says: https://www.urotoday.com/video-lectures/asco-gu-2024/video/mediaitem/3875-the-de-escalate-trial-intermittently-stopping-prostate-cancer-treatments-to-improve-quality-of-life-guillaume-grisay.html
Maxone73
in
Advanced Prostate Cancer
7 months ago
Looking for advice for my newly diagnosed dad
Hello, I was wondering if you can offer some thoughts on my dad’s situation. He was diagnosed with prostate cancer in February after a week in hospital with urine retention. A Ct scan he had in hospital showed 2 small mets in pelvic area. He’s had a biopsy which showed Gleason 4 +5 and his PSA in hospital
Hello, I was wondering if you can offer some thoughts on my dad’s situation. He was diagnosed with prostate cancer in February after a week in hospital with urine retention. A Ct scan he had in hospital showed 2 small mets in pelvic area. He’s had a biopsy which showed Gleason 4 +5 and his PSA in hospital
Springsunshi
in
Advanced Prostate Cancer
6 months ago
Gemzar and Carboplatim
Hi ladies My wife is being treat for reoccurrence of her HGOC which has progressed to lymph in her neck and liver. She is being treat with Gemzar and Carboplatin, there's been no suggestion of radiotherapy. I'm asking if anyone could advise on side effects she seems very tired , which I understand
Hi ladies My wife is being treat for reoccurrence of her HGOC which has progressed to lymph in her neck and liver. She is being treat with Gemzar and Carboplatin, there's been no suggestion of radiotherapy. I'm asking if anyone could advise on side effects she seems very tired , which I understand
Cardiff05
in
My Ovacome
3 months ago
PSA drop with decreasing Testosterone after Estrogen Patch Therapy
Here's a plot that I made from data taken from the PATCH estrogen patch therapy study. It plots the % reduction in PSA from baseline (100%) at time = 0 as a function of testosterone levels over a period of 4 weeks. As you know, estrogen effectively castrates men, causing a drop in testosterone over
Here's a plot that I made from data taken from the PATCH estrogen patch therapy study. It plots the % reduction in PSA from baseline (100%) at time = 0 as a function of testosterone levels over a period of 4 weeks. As you know, estrogen effectively castrates men, causing a drop in testosterone over
janebob99
in
Advanced Prostate Cancer
7 months ago
PSA drops with decreasing Testosterone
Here's a plot that I made from data taken from the PATCH estrogen patch therapy study. It plots the % reduction in PSA from baseline (100%) at time = 0 as a function of testosterone levels over a period of 4 weeks. As you know, estrogen effectively castrates men, causing a drop in testosterone over
Here's a plot that I made from data taken from the PATCH estrogen patch therapy study. It plots the % reduction in PSA from baseline (100%) at time = 0 as a function of testosterone levels over a period of 4 weeks. As you know, estrogen effectively castrates men, causing a drop in testosterone over
janebob99
in
Prostate Cancer Network
7 months ago
PSA spiked from .6 to 8.0 in 3 months
The blood test corroborates the MRI that shows spread. I am talking with Dr Goodman in the AM. Am I doomed? My PSA has never been 8. before
The blood test corroborates the MRI that shows spread. I am talking with Dr Goodman in the AM. Am I doomed? My PSA has never been 8. before
crony
in
Advanced Prostate Cancer
7 months ago
At the crossroads (again)
My profile is up to date, but, briefly, have failed chemo, ADT (am castrate resistant), failed Keytruda and now Pluvicto. Scans yest. & today show progression along with PSA rise. All my mets are in bone. So, my SOC choices are cabazataxel or radium 223. Other options are trial, which are a crapshoot
My profile is up to date, but, briefly, have failed chemo, ADT (am castrate resistant), failed Keytruda and now Pluvicto. Scans yest. & today show progression along with PSA rise. All my mets are in bone. So, my SOC choices are cabazataxel or radium 223. Other options are trial, which are a crapshoot
rsgdmd
in
Advanced Prostate Cancer
7 months ago
Truqap update
I persuaded my onc to start me on this new drug in April. Since starting I have had great results. My first set of labs was great, so we backed off the amount of drug due to diarrhea. I had one set back on my 2nd blood tests but adjusted my meds and am back to lower values on tumor markers. My
I persuaded my onc to start me on this new drug in April. Since starting I have had great results. My first set of labs was great, so we backed off the amount of drug due to diarrhea. I had one set back on my 2nd blood tests but adjusted my meds and am back to lower values on tumor markers. My
Bonnie1942
in
SHARE Metastatic Breast Cancer
3 months ago
Normal CA-125
I am going in for a total hysterectomy on the 25th They suspect a Granulosa Cell Tumour due the presence of a mass on my ovary and thickened womb lining However my CA-125 is in the ‘normal’ range, I am just curious if others received a DX with normal CA-125? I am ready for whatever comes but just
I am going in for a total hysterectomy on the 25th They suspect a Granulosa Cell Tumour due the presence of a mass on my ovary and thickened womb lining However my CA-125 is in the ‘normal’ range, I am just curious if others received a DX with normal CA-125? I am ready for whatever comes but just
Starflower2946
in
My Ovacome
3 months ago
Niraparib
I was diagnosed with Stage 3c high grade serous ovarian cancer in June 2023 which had spread to omentum and peritoneal lining. I had ascites which was drained twice and have developed a pleural effusion. I had the 3xchemo and debulking surgery then 3 more chemo. Finished treatment on Dec 23. ca-125
I was diagnosed with Stage 3c high grade serous ovarian cancer in June 2023 which had spread to omentum and peritoneal lining. I had ascites which was drained twice and have developed a pleural effusion. I had the 3xchemo and debulking surgery then 3 more chemo. Finished treatment on Dec 23. ca-125
Berryporridgr
in
My Ovacome
7 months ago
Pain Management
Dear All can anyone help. Diagnosed with stage 1V advanced metastatic prostate cancer December 2022. 6 sessions of Chemo, then Firmagon and Nubeqa PSA was 349 now about 1 but has been increasing. Cancer was in most bones but no organs - primarily pelvis and hips - have had radiation treatment but still
Dear All can anyone help. Diagnosed with stage 1V advanced metastatic prostate cancer December 2022. 6 sessions of Chemo, then Firmagon and Nubeqa PSA was 349 now about 1 but has been increasing. Cancer was in most bones but no organs - primarily pelvis and hips - have had radiation treatment but still
Nyon
in
Advanced Prostate Cancer
7 months ago
Rising PSA
I'm Poollover, Just got the results of a blood test and my PSA went up from 0.67 to 0.77. I'm on Orgovyx and Zytiga. I'm 86 years old. How concerned should I be? 8 months ago it was about 12. That was before medication. Also slightly anemic. What are my options? Terry
I'm Poollover, Just got the results of a blood test and my PSA went up from 0.67 to 0.77. I'm on Orgovyx and Zytiga. I'm 86 years old. How concerned should I be? 8 months ago it was about 12. That was before medication. Also slightly anemic. What are my options? Terry
Poollover
in
Advanced Prostate Cancer
7 months ago
Treatment stopped
We thought Erlotinib was working for my dad, his tumour had reduced significantly on October scan ( started on drug Aug 23) but Jan scan showed growth, cough back and has been getting steadily worse with weight down to 7 stone ,diarrhoea and debilitating fatigue. Although Oncologist thought a standard
We thought Erlotinib was working for my dad, his tumour had reduced significantly on October scan ( started on drug Aug 23) but Jan scan showed growth, cough back and has been getting steadily worse with weight down to 7 stone ,diarrhoea and debilitating fatigue. Although Oncologist thought a standard
Adaughter
in
The Roy Castle Lung Cancer Foundation
7 months ago
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