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ERLEADA® (apalutamide) - TITAN Study.
Castration
-Resistant Prostate Cancer Guidelines. http://www.auanet.org/guidelines/
castration
-resistant-prostate-cancer-(2013-amended-2018). Accessed January 2019.
Castration
-Resistant Prostate Cancer Guidelines. http://www.auanet.org/guidelines/
castration
-resistant-prostate-cancer-(2013-amended-2018). Accessed January 2019.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Quick Onset of Side Effects of Casodex and Lupron
By the time I had the first three-month Lupron my testosterone must have already reached
castration
level. The hot flushes did not completely go away year after the last Lupron shot. On November 16 this year I started taking Casodex and then on November 30 I had the first Lupron shot.
By the time I had the first three-month Lupron my testosterone must have already reached
castration
level. The hot flushes did not completely go away year after the last Lupron shot. On November 16 this year I started taking Casodex and then on November 30 I had the first Lupron shot.
dac500
in
Advanced Prostate Cancer
6 years ago
Prostate cancer Checkmate ( 650 )
According to this article : https://www.winknews.com/2018/12/06/checkmate-for-prostate-cancer/ The clinical trial , may be one these NCT02601014 , NCT03532217 , NCT02985957 , NCT03570619 or NCT03333616 Patients with advance prostate cancer , including
Castration
-resistant (CRPC) Received an IV infusion
According to this article : https://www.winknews.com/2018/12/06/checkmate-for-prostate-cancer/ The clinical trial , may be one these NCT02601014 , NCT03532217 , NCT02985957 , NCT03570619 or NCT03333616 Patients with advance prostate cancer , including
Castration
-resistant (CRPC) Received an IV infusion
bboby
in
Advanced Prostate Cancer
6 years ago
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Darolutamide ARAMIS study.
Among the data presented will be the first results on the investigational cancer treatment darolutamide from the pivotal Phase III ARAMIS trial, a randomized, double-blind, placebo-controlled study to assess the safety and efficacy of darolutamide in patients with non-metastatic
castration
-resistant
Among the data presented will be the first results on the investigational cancer treatment darolutamide from the pivotal Phase III ARAMIS trial, a randomized, double-blind, placebo-controlled study to assess the safety and efficacy of darolutamide in patients with non-metastatic
castration
-resistant
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Delta-Tocotrienol.
Abstract OBJECTIVES: Prostate cancer, after the phase of androgen dependence, may progress to the
castration
-resistant prostate cancer (CRPC) stage, with resistance to standard therapies. Vitamin E-derived tocotrienols (TTs) possess a significant antitumour activity.
Abstract OBJECTIVES: Prostate cancer, after the phase of androgen dependence, may progress to the
castration
-resistant prostate cancer (CRPC) stage, with resistance to standard therapies. Vitamin E-derived tocotrienols (TTs) possess a significant antitumour activity.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Docetaxel timing in CRPC patients who had a poor response on ADT.
KEYWORDS: Androgen deprivation therapy; Docetaxel; Metastatic
castration
-resistant prostate cancer PMID: 30604159 DOI: 10.1007/s10147-018-01388-5
KEYWORDS: Androgen deprivation therapy; Docetaxel; Metastatic
castration
-resistant prostate cancer PMID: 30604159 DOI: 10.1007/s10147-018-01388-5
pjoshea13
in
Advanced Prostate Cancer
6 years ago
IL-23 promotes the development of castration-resistant prostate cancer
Let's hope they're on to something..... https://www.researchgate.net/publication/327539342_IL-23_promotes_the_development_of_castration-resistant_prostate_cancer Ron
Let's hope they're on to something..... https://www.researchgate.net/publication/327539342_IL-23_promotes_the_development_of_castration-resistant_prostate_cancer Ron
Dayatatime
in
Advanced Prostate Cancer
6 years ago
Castration resistant after 20 months on ADT
Hi all, this is my first post on this site, so I will offer a little background on my experience with prostate cancer. I was diagnosed in 2016 with a 4+3 Gleason 7. I was 53 yrs old at the time. I opted for RP surgery and received not such good news after pathology was done. 1/4 of the prostate was
Hi all, this is my first post on this site, so I will offer a little background on my experience with prostate cancer. I was diagnosed in 2016 with a 4+3 Gleason 7. I was 53 yrs old at the time. I opted for RP surgery and received not such good news after pathology was done. 1/4 of the prostate was
joeguy
in
Advanced Prostate Cancer
6 years ago
Holy Cow!....Indomethacin + Xtandi
kills cancer cells...I just got my Doc to write a prescription Gus http://ascopubs.org/doi/abs/10.1200/JCO.2018.36.6_suppl.TPS394 https://www.urotoday.com/conference-highlights/asco-gu-2018/asco-gu-2018-prostate-cancer/101841-asco-gu-2018-a-phase-ib-ii-trial-of-indomethacin-and-enzalutamide-to-treat-
castration
-resistant-prostate-cancer.html
kills cancer cells...I just got my Doc to write a prescription Gus http://ascopubs.org/doi/abs/10.1200/JCO.2018.36.6_suppl.TPS394 https://www.urotoday.com/conference-highlights/asco-gu-2018/asco-gu-2018-prostate-cancer/101841-asco-gu-2018-a-phase-ib-ii-trial-of-indomethacin-and-enzalutamide-to-treat-
castration
-resistant-prostate-cancer.html
gusgold
in
Advanced Prostate Cancer
6 years ago
Phase 3 ARCHES trial - Enzalutamide + ADT
Adverse events (AEs) in the ARCHES clinical trial were generally consistent with those reported in enzalutamide clinical trials in patients with
castration
-resistant prostate cancer (CRPC).
Adverse events (AEs) in the ARCHES clinical trial were generally consistent with those reported in enzalutamide clinical trials in patients with
castration
-resistant prostate cancer (CRPC).
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Dihydrotestosterone [DHT] & PCa castration resistance [CRPC].
Together, these findings couple a mechanism with a functional imaging modality to identify impending
castration
resistance in prostate cancers.
Together, these findings couple a mechanism with a functional imaging modality to identify impending
castration
resistance in prostate cancers.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Intermittent vs. Continuous ADT Treatment--Intriguing Research from State of the Science Report
through various mechanisms, including via tumor cells gaining the ability to produce their own testosterone. 53 State of the Science Report | 25th Annual PCF Scientific Retreat •An adaptive therapy trial was initiated to test intermittent administration of abiraterone in patients with metastatic
castration
-resistant
through various mechanisms, including via tumor cells gaining the ability to produce their own testosterone. 53 State of the Science Report | 25th Annual PCF Scientific Retreat •An adaptive therapy trial was initiated to test intermittent administration of abiraterone in patients with metastatic
castration
-resistant
Balsam01
in
Advanced Prostate Cancer
5 years ago
Ever Wonder Why Beating PCa Is So Hard - Read This
Gus https://www.dovepress.com/enzalutamide-resistant-
castration
-resistant-prostate-cancer-challenges-peer-reviewed-fulltext-article-OTT
Gus https://www.dovepress.com/enzalutamide-resistant-
castration
-resistant-prostate-cancer-challenges-peer-reviewed-fulltext-article-OTT
gusgold
in
Advanced Prostate Cancer
6 years ago
Dutasteride [Avodart] & Abiraterone [Zytiga]?
. & now there is another reason for Avodart use: From a 2016 paper (Cleveland Clinic) [2]: "Abiraterone {Abi} blocks androgen synthesis and prolongs survival in
castration
-resistant prostate cancer, which is otherwise driven by intratumoral androgen synthesis."
. & now there is another reason for Avodart use: From a 2016 paper (Cleveland Clinic) [2]: "Abiraterone {Abi} blocks androgen synthesis and prolongs survival in
castration
-resistant prostate cancer, which is otherwise driven by intratumoral androgen synthesis."
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Androgen Deprivation Therapy & Gleason 8 Versus Gleason 9-10.
Consideration should be given to treatment intensification for Gleason 9-10 patients through enrollment in clinical trials or potentially adding novel antiandrogens or docetaxel, which have shown efficacy in both
castration
-resistant and
castration
-sensitive settings."
Consideration should be given to treatment intensification for Gleason 9-10 patients through enrollment in clinical trials or potentially adding novel antiandrogens or docetaxel, which have shown efficacy in both
castration
-resistant and
castration
-sensitive settings."
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Low Tristetraprolin Expression is Associated with Lethal Prostate Cancer.
Tristetraprolin expression levels in prostatectomy samples from patients with localized disease and biopsies of metastatic
castration
resistant PrCa (mCRPC) were assessed in a Cornell University cohort."
Tristetraprolin expression levels in prostatectomy samples from patients with localized disease and biopsies of metastatic
castration
resistant PrCa (mCRPC) were assessed in a Cornell University cohort."
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Metastasis-Free Survival in Prostate Cancer: Faster Drug Approvals, Better Drugs?
The SPARTAN (A Study of Apalutamide [ARN-509] in Men With Non-Metastatic
Castration
-Resistant Prostate Cancer) and PROSPER (Safety and Efficacy Study of Enzalutamide in Patients With Nonmetastatic
Castration
-Resistant Prostate Cancer) trials, which led to the two recent approvals, suggest that it is
The SPARTAN (A Study of Apalutamide [ARN-509] in Men With Non-Metastatic
Castration
-Resistant Prostate Cancer) and PROSPER (Safety and Efficacy Study of Enzalutamide in Patients With Nonmetastatic
Castration
-Resistant Prostate Cancer) trials, which led to the two recent approvals, suggest that it is
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Cancer cell dormancy: mechanisms and implications of cancer recurrence and metastasis
There is a very old rat study where
castration
leads to involution of the prostate - it all but disappears. However, with testosterone treatment, the prostate grows back to normal size.
Castration
does not affect stem cells because they do not need androgen; they have no androgen receptor.
There is a very old rat study where
castration
leads to involution of the prostate - it all but disappears. However, with testosterone treatment, the prostate grows back to normal size.
Castration
does not affect stem cells because they do not need androgen; they have no androgen receptor.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Melatonin - AR-V7 Splice Variant.
Of note, melatonin, by inhibiting NF-κB activation via the previously-reported MT1 receptor-mediated antiproliferative pathway, can disrupt these bi-directional positive interactions between AR-V7 and NF-κB and thereby delay the development of
castration
resistance in advanced prostate cancer."
Of note, melatonin, by inhibiting NF-κB activation via the previously-reported MT1 receptor-mediated antiproliferative pathway, can disrupt these bi-directional positive interactions between AR-V7 and NF-κB and thereby delay the development of
castration
resistance in advanced prostate cancer."
pjoshea13
in
Advanced Prostate Cancer
6 years ago
"Novel Hormonal Therapies" Before and After Chemotherapy
Abstract BACKGROUND: Novel hormonal therapies (NHTs) have enriched the therapeutic armamentarium available for patients with
castration
-resistant prostate cancer. However, there is a need for clinical indicators able to drive treatment decisions and timing.
Abstract BACKGROUND: Novel hormonal therapies (NHTs) have enriched the therapeutic armamentarium available for patients with
castration
-resistant prostate cancer. However, there is a need for clinical indicators able to drive treatment decisions and timing.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
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