Holy Cow!....Indomethacin + Xtandi

[gusgold]

Indo can block resistance to Enza and Xtandi and the combo kills cancer cells...I just got my Doc to write a prescription

Gus

ascopubs.org/doi/abs/10.120...

urotoday.com/conference-hig...

[JamesAtlanta]

Congratulations!!!🎊🍾

[Tall_Allen]

I hope it works in humans

clinicaltrials.gov/ct2/show...

Celecoxib alone had no effect in humans, but when combined with Zometa, it increased survival by 22% in metastatic hormone-sensitive men. Maybe combining an NSAID with Xtandi is synergistic?

[gusgold in reply to Tall_Allen]

TA,

check this out...early indications worked in 3 out of 4

urotoday.com/conference-hig...

[Tall_Allen in reply to gusgold]

VERY small group (4) of patients. Their phase 1/2 trial is only 38 patients. it'll be several years more if they go to a phase 3 trial. Meanwhile, if you have no contraindications, why not (especially if you have gout)? Consider taking prilosec with it to prevent gastric upset. Here are potential side effects:

online.epocrates.com/drugs/...

[henukit in reply to Tall_Allen]

This maybe effect common among other COX inhibitors. There's definitely something going on that scientists still don't understand yet the sparse data shows benefits here and there. Perhaps combination with not only Zometa but other drugs show synergistic effect. All that said, my oncologist at MD Anderson encouraged my past use of Celebrex during chemo and now.

[Break60 in reply to Tall_Allen]

TA

I’ve been on celecoxib for years before and after dx with PCa while on adt and for the last two years on xgeva. Is this similar in any way?

Bob

[Tall_Allen in reply to Break60]

Only if you're taking Zometa or Xgeva

[Break60 in reply to Tall_Allen]

Which I am . Thanks and merry Christmas!

[rassusukumaran in reply to Tall_Allen]

Allen,

You mentioned something about combining Celecoxib with Zometa. I get a Zometa infusion once every 6 months roughly. Am due for my next one in about a week. Would appreciate any information on how Celecoxib is to be taken with Zometa. Should it be before or after the infusion and is there any indication of dosage and for how long has one got to be on the drug after infusion. I would appreciate your guidance on this.

[Tall_Allen in reply to rassusukumaran]

Celebrex is taken every day -- 400 mg was administered twice a day. The two drugs together improved survival in metastatic men by 22%. Here's the study if you want to discuss it with your oncologist:

ascopubs.org/doi/10.1200/JC...

[rassusukumaran in reply to Tall_Allen]

Allen,

Have got it. I could not thank you enough. Will show study to Onco. Tks again.

[Rkoma in reply to Tall_Allen]

TA,

How should I understand following statement from trial:

Survival

There were 303 deaths (251 deaths related to CaP; 83%) in the SOC-only group; median survival was 66 months; and 5-year survival was 53%. There was no evidence of a survival advantage for SOC + Cel (HR, 0.98; 95% CI, 0.80 to 1.20; P = .847: 143 deaths [117 deaths related to CaP; 82%]); median survival was 70 months; and 5-year survival was 54%. Nor was there evidence of a survival advantage for SOC + ZA + Cel (HR, 0.86; 95% CI, 0.70 to 1.05; P = .130: 138 deaths [103 deaths related to CaP; 75%]); median survival was 76 months; and 5-year survival was 59% (Figs 2B and 2D). There was no evidence of nonproportional hazards data.

[Tall_Allen in reply to Rkoma]

I'm not sure exactly what it is that needs explaining - could you be more specific?

[erjlg3]

WooHoo Gus.

[NPfisherman]

Can you wash it down with a Birm and flax lignans smoothie?

Good luck...indomethacin is tough on the gut....always with food....

[tango65]

Indomethacin is a powerful NSAID. It could have serious side effects, particularly cardiovascular, renal and bleeding complications. In the trial they give 50 to 100 mg a day. Do not take it without consulting with your doctor.

rxlist.com/indocin-drug.htm...

studypages.com/s/a-study-of...

[COG1]

Hmmm...Indomethacin is not allowed in the trial my husband in on is for early use of Xtandi in castrate sensitive, non-metastatic men. He has gout and had to stop use of Indo before he could enter the trial.

[COG1 in reply to COG1]

We were told the combination could cause kidney/liver issues.

[Drcrunch]

Try Rutin, little brother of vitamin c. Block same enzyme as a indocin and can cure hemorrhoids also. It is a bioflavonoid. Sold in capsules.

[PhilipSZacarias]

Hello Gus, yes indomethacin may slow progression because it blocks the ARK1C3 enzyme and therefore steriodogenesis. I am contemplating taking this or another NSAID (currently taking naproxen) as well, but please review the side effects associated with this pain killer. It can increase the risk of a cardiovascular incident. I would recommend taking resveratrol along with indomethacin which appears to have cardioprotective properties (search PubMed). To the best of my knowledge there is no direct evidence that resveratrol ameliorates the potential damage/risk that can be caused by indomethacin, but based on resveratrol's effect on the cardiovascular system it may help. Resveratrol should be taken on an empty stomach, one hours before or two hours after the last meal - food appears to hamper absorption. Piperine, or Bioperine, may improve absorption. Regards, Phil

[gusgold]

PZ,

If a guy has failed Xtandi and Enza with crMPCa why worry about the potential side effects of a NSAID, the idiots on this board who are saying this will be long dead of PCa before any side effects will hurt you. Like any NSAID I plan on taking Prilosec and Pepto Bismol. They banned the COX 2 inhibitors for the same reason, then brought back Celebrex....When the ban went into effect my Doc took home every bottle in the clinic and said they were full of shit. Look how Lupron effects cardiovascular...that is why I am on Xtandi monotherapy.

[riichardd]

Hi gus, what dose of indomethacin were you planning on taking? I'm trying Xtandi after Docetaxol has failed. So i guess if Xtandi works It would be a sensible idea to use indomethacin to get as much time out of Xtandi as i can. Ive been on Xtandi less than a fortnight so its early days to say if its going to help me or not.But I might as well start indomethacin now if it isn't going to do me any harm i'm already on lanzoprazole so thats going to afford some protection to my gut. I seem to have a particularily aggressive form of PC so my fingers are crossed Xtandi works for me

[gusgold]

Most of the studies used 50 mg x3 but that is too close to max dose of 200mg...so I am going to use 50mg x2