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I vitro evidence for effectiveness of Simvastatin Metformin combination against Enzalutamide resistant CRPC
Malignant cells initially respond to ADT, but subsequently colonize and re-emerge as more aggressive phenotype known as
castration
resistant prostate cancer (CRPC).
Malignant cells initially respond to ADT, but subsequently colonize and re-emerge as more aggressive phenotype known as
castration
resistant prostate cancer (CRPC).
Graham49
in
Advanced Prostate Cancer
4 years ago
To treat or not to treat: is it acceptable to avoid active therapies in advanced prostate cancer today?
In non-metastatic
castration
-resistant prostate cancer (PCa), all patients with a PSA doubling time of ≤6 months should receive one ARTA, whereas the others might wait until there is an acceleration in the kinetics of their PSA levels."
In non-metastatic
castration
-resistant prostate cancer (PCa), all patients with a PSA doubling time of ≤6 months should receive one ARTA, whereas the others might wait until there is an acceleration in the kinetics of their PSA levels."
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Ra223 Xofigo and Cabazataxel compared
Here are some sites I found were worth reading.............. https://www.hematologyandoncology.net/archives/september-2017/optimal-use-of-radium-223-in-patients-with-metastatic-
castration
-resistant-prostate-cancer/ https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/radiotherapy
Here are some sites I found were worth reading.............. https://www.hematologyandoncology.net/archives/september-2017/optimal-use-of-radium-223-in-patients-with-metastatic-
castration
-resistant-prostate-cancer/ https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/radiotherapy
Patrick-Turner
in
Advanced Prostate Cancer
4 years ago
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Resetting the Bar of Castration Resistance - Understanding Androgen Dynamics in Therapy Resistance and Treatment Choice in PCa
) Consistent suppression of testosterone (T) to
castration
level remains critical in the management of
castration
-resistant prostate cancer (CRPC).
) Consistent suppression of testosterone (T) to
castration
level remains critical in the management of
castration
-resistant prostate cancer (CRPC).
pjoshea13
in
Advanced Prostate Cancer
4 years ago
16 days post op orchiectomy...today I had bloodwork drawn.
Hoping it stays stable or even dips...from less Testosterone since my physical
castration
. Only time will tell what the next leg of the journey will look like. Cool thing...neither of us has ANYTHING in our schedule for tomorrow. A day of "carpe diem".
Hoping it stays stable or even dips...from less Testosterone since my physical
castration
. Only time will tell what the next leg of the journey will look like. Cool thing...neither of us has ANYTHING in our schedule for tomorrow. A day of "carpe diem".
greatjohn
in
Prostate Cancer And Gay Men
4 years ago
Bruceantin, an amoebicidal anti-malarial agent from a plant, Brucea antidysenterica identified as potential drug for castrate resistant PCa
via full-length AR (AR-FL) and constitutively active AR variant 7 (AR-V7) plays a key role in the development of
castration
-resistant prostate cancer (CRPC) and resistance to hormone therapies.
via full-length AR (AR-FL) and constitutively active AR variant 7 (AR-V7) plays a key role in the development of
castration
-resistant prostate cancer (CRPC) and resistance to hormone therapies.
Graham49
in
Advanced Prostate Cancer
4 years ago
Bipolar androgen therapy [BAT] sensitizes CRPC to subsequent ADT
Keywords: Bipolar androgen therapy;
Castration
-resistant prostate cancer; RESTORE trial; Testosterone. Copyright © 2020 Elsevier Ltd. All rights reserved.
Keywords: Bipolar androgen therapy;
Castration
-resistant prostate cancer; RESTORE trial; Testosterone. Copyright © 2020 Elsevier Ltd. All rights reserved.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
The Road Less Traveled
This discussion on
castration
makes clear why the word “
castration
” has largely dropped out of oncology’s lexicon. The oncology community gets a Madison Ave. award for relabeling
castration
as ” Hormone Therapy” or ” Androgen Deprivation Therapy”.
This discussion on
castration
makes clear why the word “
castration
” has largely dropped out of oncology’s lexicon. The oncology community gets a Madison Ave. award for relabeling
castration
as ” Hormone Therapy” or ” Androgen Deprivation Therapy”.
Darryl
Partner
in
Advanced Prostate Cancer
4 years ago
Enzalutamide resistance & IKKB
"Although enzalutamide (ENZ) has been widely used to treat de novo or
castration
-resistant metastatic prostate cancer, resistance develops, and disease progression is ultimately inevitable.
"Although enzalutamide (ENZ) has been widely used to treat de novo or
castration
-resistant metastatic prostate cancer, resistance develops, and disease progression is ultimately inevitable.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Sequencing Opportunity?
https://www.urotoday.com/conference-highlights/asco-2020/asco-2020-prostate-cancer/121890-asco-2020-transformer-bipolar-androgen-therapy-vs-enzalutamide-for-
castration
-resistant-metastatic-prostate-cancer.html
https://www.urotoday.com/conference-highlights/asco-2020/asco-2020-prostate-cancer/121890-asco-2020-transformer-bipolar-androgen-therapy-vs-enzalutamide-for-
castration
-resistant-metastatic-prostate-cancer.html
taylor123
in
Advanced Prostate Cancer
4 years ago
New Trial of Lu-177-PSMA-617 to begin April 30, 2021.
Participants must have progressive metastatic
castration
-resistant PC. There must be at least 1 metastasis identified in the last month with bone scan/CT/MRI.
Participants must have progressive metastatic
castration
-resistant PC. There must be at least 1 metastasis identified in the last month with bone scan/CT/MRI.
Tall_Allen
in
Advanced Prostate Cancer
4 years ago
Emasculated in Man Leggings
It was an eye-watering experience, and one that convinced me that I'm not a great fan of
castration
, so I vowed there and then that it would be [i]commando[/i] for then on out.
It was an eye-watering experience, and one that convinced me that I'm not a great fan of
castration
, so I vowed there and then that it would be [i]commando[/i] for then on out.
PaulS83
in
Couch to 5K
4 years ago
Oral chemo
Vaishampayan ModraDoc006, a novel oral docetaxel formulation, has advantages as a convenient, oral, and better-tolerated potential therapeutic option for patients with metastatic
castration
-resistant prostate cancer (mCRPC) when combined with ritonavir (ModraDoc006/r; Abstract 132).
Vaishampayan ModraDoc006, a novel oral docetaxel formulation, has advantages as a convenient, oral, and better-tolerated potential therapeutic option for patients with metastatic
castration
-resistant prostate cancer (mCRPC) when combined with ritonavir (ModraDoc006/r; Abstract 132).
podsart
in
Advanced Prostate Cancer
3 years ago
"Superoxide dismutase (SOD) can be considered as a therapy for late-stage prostate cancer" only an in vitro study I'm afraid
Methods: We used the prostate cancer cells from secondary prostate cancer cell lines (PC-3) derived from
castration
refractory prostate cancer (CRPC), cell differentiation grade IV, and had metastasized to the bone from the American Type Culture Collection (ATCC, Rockville, MD, USA).
Methods: We used the prostate cancer cells from secondary prostate cancer cell lines (PC-3) derived from
castration
refractory prostate cancer (CRPC), cell differentiation grade IV, and had metastasized to the bone from the American Type Culture Collection (ATCC, Rockville, MD, USA).
Graham49
in
Advanced Prostate Cancer
4 years ago
Baseline Serum Testosterone & ADT Outcome.
Keywords: Low-testosterone;
castration
; prognostic; prostate cancer.
Keywords: Low-testosterone;
castration
; prognostic; prostate cancer.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Estrogen receptor β regulates AKT activity through up-regulation of INPP4B and inhibits migration of prostate cancer cell line PC-3
Complete loss of PTEN is associated with increased metastasis and
castration
resistance in PCa. However, another tumor suppressor, inositol-polyphosphate 4-phosphatase type II (INPP4B), can partially compensate for the loss of PTEN.
Complete loss of PTEN is associated with increased metastasis and
castration
resistance in PCa. However, another tumor suppressor, inositol-polyphosphate 4-phosphatase type II (INPP4B), can partially compensate for the loss of PTEN.
George71
in
Advanced Prostate Cancer
4 years ago
6-month Update: PSA down / Testosterone up
His MO is a little surprised with this "unusual" situation with very good response without
castration
levels.
His MO is a little surprised with this "unusual" situation with very good response without
castration
levels.
olloreda
in
Advanced Prostate Cancer
4 years ago
Methylprednisolone acetate with Lupron
Hubby has had four successful shots of Lupron ( 1 every 6 months) for prostate cancer, which has lowered both his PSA levels and testosterone to medical
castration
levels(13).
Hubby has had four successful shots of Lupron ( 1 every 6 months) for prostate cancer, which has lowered both his PSA levels and testosterone to medical
castration
levels(13).
Hidden
in
Advanced Prostate Cancer
4 years ago
PSCA phase one trial
http://www.globenewswire.com/news-release/2020/10/26/2114227/0/en/Mustang-Bio-Announces-Initial-Phase-1-Data-on-MB-105-for-Patients-with-PSCA-positive-
Castration
-Resistant-Prostate-Cancer.html
http://www.globenewswire.com/news-release/2020/10/26/2114227/0/en/Mustang-Bio-Announces-Initial-Phase-1-Data-on-MB-105-for-Patients-with-PSCA-positive-
Castration
-Resistant-Prostate-Cancer.html
Faith1111
in
Advanced Prostate Cancer
4 years ago
Are there really fewer side effects with surgical castration over luprin?
My question is for anyone that might have tried Luprin, and had similar issues, and opted for surgical
castration
to reduce side effects. Or comments from anyone who has had surgical
castration
. It wouldnt affect my sexual issues, as the nerves were damaged in my prostectomy. Hangin in there.
My question is for anyone that might have tried Luprin, and had similar issues, and opted for surgical
castration
to reduce side effects. Or comments from anyone who has had surgical
castration
. It wouldnt affect my sexual issues, as the nerves were damaged in my prostectomy. Hangin in there.
MobilityTech
in
Advanced Prostate Cancer
4 years ago
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