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Carbidopa / Levodopa
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Which would you rather have? Violent dyskinesia or go back to less L-dopa? Are there other options? Can we thread the needle and avoid both?
Taken from "Once Upon a Pill":
Ater this patient reduced his medication slowly and carefully over more than a year, the violent ticcing stopped and his original tremor – a small, fluttering, weak movement – reappeared, amazing him and his family. For the first time, the family members were willing
Taken from "Once Upon a Pill":
Ater this patient reduced his medication slowly and carefully over more than a year, the violent ticcing stopped and his original tremor – a small, fluttering, weak movement – reappeared, amazing him and his family. For the first time, the family members were willing
JAS9
in
Cure Parkinson's
5 years ago
VITAMANIA; A historical documentary on vitamins and supplements. From CuriosityStream (90 mins)
“100 years ago a new word in medicine was invented: vitamin. This year the world will spend over $100,000,000,000 on vitamins and supplements. ($40,000,000,000 in the US.) Dr. Derek Muller takes us on a world spanning investigation of vitamin science and history, asking how do we decide whether to take
“100 years ago a new word in medicine was invented: vitamin. This year the world will spend over $100,000,000,000 on vitamins and supplements. ($40,000,000,000 in the US.) Dr. Derek Muller takes us on a world spanning investigation of vitamin science and history, asking how do we decide whether to take
MBAnderson
in
Cure Parkinson's
5 years ago
Age old question: does PD or L/C cause Dyskinesia?
I know there are recent studies out there that say that L/C doesn't - that PD's progression does. So someone just diagnosed might as well start on L/C straight away, right? But does anyone [i]really [/i]know? Are the studies funded by the drug companies somehow? Asking for a recently diagnosed friend
I know there are recent studies out there that say that L/C doesn't - that PD's progression does. So someone just diagnosed might as well start on L/C straight away, right? But does anyone [i]really [/i]know? Are the studies funded by the drug companies somehow? Asking for a recently diagnosed friend
JAS9
in
Cure Parkinson's
5 years ago
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The Cause Of Vitamin B-6 Toxicity (Updated)
Different forms of vitamin B-6. Credit: https://openi.nlm.nih.gov/detailedresult?img=PMC3412620_pone.0040954.g001&req=4. Carbidopa uses up vitamin B6. Vitamin B6 is essential for all manner of biochemical wizardry, so it is not something we want to be short of. Vitamin B6 and carbidopa bind together
Different forms of vitamin B-6. Credit: https://openi.nlm.nih.gov/detailedresult?img=PMC3412620_pone.0040954.g001&req=4. Carbidopa uses up vitamin B6. Vitamin B6 is essential for all manner of biochemical wizardry, so it is not something we want to be short of. Vitamin B6 and carbidopa bind together
park_bear
in
Cure Parkinson's
5 years ago
Who's taking Grapefruit juice and does it help you ?
It's now 2 months since I posted my article on the inhibition of Cytochrome P450 enzymes by Grapefruit juice and it's likely effect on improving the bio-availability of levodopa. If you tried it for a significant period, say 2 weeks or more, let me know how it worked for you. What dose did you take
It's now 2 months since I posted my article on the inhibition of Cytochrome P450 enzymes by Grapefruit juice and it's likely effect on improving the bio-availability of levodopa. If you tried it for a significant period, say 2 weeks or more, let me know how it worked for you. What dose did you take
wriga
in
Cure Parkinson's
5 years ago
Punding
Would like to hear from others about their response to lowered levodopa to reduce punding.
Would like to hear from others about their response to lowered levodopa to reduce punding.
BaakP
in
Cure Parkinson's
5 years ago
current neurologist exam
My neurologist said
carbidopa
levodopa
is not useful with tremors. He said its function is to get you moving. I am trying to post today's pull test video. Watch for it.
My neurologist said
carbidopa
levodopa
is not useful with tremors. He said its function is to get you moving. I am trying to post today's pull test video. Watch for it.
Hidden
in
Cure Parkinson's
5 years ago
Fred Phillips on drugs. Part 2
His experience with
Carbidopa
levodopa
, how much he is taking. Also his hope for getting off the
carbidopa
-
levodopa
down the line.
His experience with
Carbidopa
levodopa
, how much he is taking. Also his hope for getting off the
carbidopa
-
levodopa
down the line.
parkie13
in
Cure Parkinson's
5 years ago
Levodopa carbidopa starts to work 2:30 hrs after taking it...
Would anyone care to speculate why
Levodopa
carbidopa
100/25 - 3 x daily - taken 2 hrs after meals, only kicks in 2:30 hrs after swallowing and works only for about 30 min... I have been taking it since mid Feb. A couple of days after starting, I got this new rigidity that looks like dystonia .
Would anyone care to speculate why
Levodopa
carbidopa
100/25 - 3 x daily - taken 2 hrs after meals, only kicks in 2:30 hrs after swallowing and works only for about 30 min... I have been taking it since mid Feb. A couple of days after starting, I got this new rigidity that looks like dystonia .
Parkie-
in
Cure Parkinson's
5 years ago
Dystonia and Parkinson's disease: What is the relationship?
Dystonia and Parkinson's disease are closely linked disorders sharing many pathophysiological overlaps. Dystonia can be seen in 30% or more of the patients suffering with PD and sometimes can precede the overt parkinsonism. The response of early dystonia to the introduction of dopamine replacement therapy
Dystonia and Parkinson's disease are closely linked disorders sharing many pathophysiological overlaps. Dystonia can be seen in 30% or more of the patients suffering with PD and sometimes can precede the overt parkinsonism. The response of early dystonia to the introduction of dopamine replacement therapy
Farooqji
in
Cure Parkinson's
5 years ago
Levodopa-Sparing Medications May Help Patients in Early Stages of Parkinson’s, Study Suggests
Neurologists treating patients with early-stage Parkinson’s disease should prescribe more often therapies that spare patients from starting levodopa too soon in order to delay onset of side effects associated with long-term use of the medicine, findings from a study conducted in Romania suggest. https
Neurologists treating patients with early-stage Parkinson’s disease should prescribe more often therapies that spare patients from starting levodopa too soon in order to delay onset of side effects associated with long-term use of the medicine, findings from a study conducted in Romania suggest. https
Farooqji
in
Cure Parkinson's
5 years ago
Falls gait cholinergic pedunculopontine Bohnen it al 2009
History of falls in Parkinson disease is associated with reduced cholinergic activity. N I. Bohnen, MD, PhD, M L.T.M. Müller, PhD, [...], and R L. Albin, MD. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788804/ Falls are common and disabling in Parkinson disease (PD).1 Because of nigrostriatal pathology
History of falls in Parkinson disease is associated with reduced cholinergic activity. N I. Bohnen, MD, PhD, M L.T.M. Müller, PhD, [...], and R L. Albin, MD. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788804/ Falls are common and disabling in Parkinson disease (PD).1 Because of nigrostriatal pathology
aspergerian
in
Cure Parkinson's
5 years ago
Depression and drugs
We are experimenting now with
carbidopa
-
levodopa
, to help with stiffness. This is an experiment because hubby’s DAT scan does not reveal Parkinson’s. We think he has Parkinsonism traits, but not Parkinson’s (CONFUSING!).
We are experimenting now with
carbidopa
-
levodopa
, to help with stiffness. This is an experiment because hubby’s DAT scan does not reveal Parkinson’s. We think he has Parkinsonism traits, but not Parkinson’s (CONFUSING!).
SewBears
in
PSP Association
5 years ago
Microwave-induced stimulation of l-DOPA, phenolics and antioxidantactivity in fava bean (Vicia faba) for Parkinson’s diet
https://filebin.net/2lh4g8tjw0ed4wkx/j.procbio.2003.08.006.pdf?t=kcwotjng
https://filebin.net/2lh4g8tjw0ed4wkx/j.procbio.2003.08.006.pdf?t=kcwotjng
Farooqji
in
Cure Parkinson's
5 years ago
Annual neurological check
This morning I made the annual neurological check from my PD diagnosis of May 2018. The therapy was 2 tablet Sinemet 100+25 mg. per day. Compared to the previous control, has been confirmed the substantial stability of the general situation. Pull test ok, cognitive tests ok, engine tests ok, balance
This morning I made the annual neurological check from my PD diagnosis of May 2018. The therapy was 2 tablet Sinemet 100+25 mg. per day. Compared to the previous control, has been confirmed the substantial stability of the general situation. Pull test ok, cognitive tests ok, engine tests ok, balance
Fed1000
in
Cure Parkinson's
5 years ago
Recruiting for Phase 2 - (RESTORE-1 Clinical Study)
Based on the positive results from both the PD-1101 and PD-1102 trials, researchers have launched the RESTORE-1 Phase 2 trial (NCT03562494). The trial, currently recruiting participants, will randomize patients with advanced Parkinson’s disease who have failed to respond properly to oral therapy to either
Based on the positive results from both the PD-1101 and PD-1102 trials, researchers have launched the RESTORE-1 Phase 2 trial (NCT03562494). The trial, currently recruiting participants, will randomize patients with advanced Parkinson’s disease who have failed to respond properly to oral therapy to either
Farooqji
in
Cure Parkinson's
5 years ago
Inhaled Levodopa Effectively Maintains ON State in Parkinson Disease
Levodopa inhalation powder (Inbrija, Acorda Therapeutics) has demonstrated efficacy among individuals with Parkinson disease in achieving an ON state during OFF periods, as well as in gaining more dyskinesia-free ON time and lowering the daily amount of OFF time, according to research presented at the
Levodopa inhalation powder (Inbrija, Acorda Therapeutics) has demonstrated efficacy among individuals with Parkinson disease in achieving an ON state during OFF periods, as well as in gaining more dyskinesia-free ON time and lowering the daily amount of OFF time, according to research presented at the
Farooqji
in
Cure Parkinson's
5 years ago
Skipping doses?
A week of January, and doses he’s missed along the way of the
Carbidopa
Levodopa
. I’m beside myself. So I threw it all under the sink and opened the box he should be on right now. Is this purposeful? Inability? Stubbornness? Rant over.
A week of January, and doses he’s missed along the way of the
Carbidopa
Levodopa
. I’m beside myself. So I threw it all under the sink and opened the box he should be on right now. Is this purposeful? Inability? Stubbornness? Rant over.
3Fishies
in
Cure Parkinson's
5 years ago
Neurocrine Biosciences Presents Phase III Data Analysis Demonstrating That Opicapone Added To Levodopa Resulted In A Significant improvement
Neurocrine Biosciences Presents Phase III Data Analysis Demonstrating That Opicapone Added To Levodopa Resulted In A Significant And Sustained Increase In ON Time Without Troublesome Dyskinesia In Parkinson's Disease Patients With Motor Fluctuations https://www.gurufocus.com/news/870917/neurocrine-biosciences-presents-phase-iii-data-analysis-demonstrating-that-opicapone-added-to-levodopa-resulted-in-a-significant-and-sustained-increase-in-on-time-without-troublesome-dyskinesia-in-parkinsons-disease-patients-with-motor-fluctuations
Neurocrine Biosciences Presents Phase III Data Analysis Demonstrating That Opicapone Added To Levodopa Resulted In A Significant And Sustained Increase In ON Time Without Troublesome Dyskinesia In Parkinson's Disease Patients With Motor Fluctuations https://www.gurufocus.com/news/870917/neurocrine-biosciences-presents-phase-iii-data-analysis-demonstrating-that-opicapone-added-to-levodopa-resulted-in-a-significant-and-sustained-increase-in-on-time-without-troublesome-dyskinesia-in-parkinsons-disease-patients-with-motor-fluctuations
Farooqji
in
Cure Parkinson's
5 years ago
Medication not working
My husband was on
carbidopa
levodopa
er by mylan and was doing well. After they were not able to manufacture since last year he had to switch to the sun product which is not working. His tremers are back, he is losing the ability to use the usage of his mobility more and more.
My husband was on
carbidopa
levodopa
er by mylan and was doing well. After they were not able to manufacture since last year he had to switch to the sun product which is not working. His tremers are back, he is losing the ability to use the usage of his mobility more and more.
berlinwest1989
in
Cure Parkinson's
6 years ago
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