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A "Novel" CRPC Mechanism.
New study below [1]. Not so long ago, PCa that was refractory (i.e. resistant) to ADT was described as being hormone independent. The three dominant cell lines in PCa research have been LNCaP (from lymph node), DU145 (from brain) & PC-3 (from bone). PC-3 "cells do not respond to androgens" & "do not
New study below [1]. Not so long ago, PCa that was refractory (i.e. resistant) to ADT was described as being hormone independent. The three dominant cell lines in PCa research have been LNCaP (from lymph node), DU145 (from brain) & PC-3 (from bone). PC-3 "cells do not respond to androgens" & "do not
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Vitamin D and its Many Effects in People with PD
I have been gathering information on different supplements for several of my friends who have PD. The list has grown to well over 50 supplements now so in order to make it manageable, I am trying to narrow the list down to either 5 or 10 supplements that seem to show the most evidence in the form of
I have been gathering information on different supplements for several of my friends who have PD. The list has grown to well over 50 supplements now so in order to make it manageable, I am trying to narrow the list down to either 5 or 10 supplements that seem to show the most evidence in the form of
Hidden
in
Cure Parkinson's
6 years ago
First Week Following First Chemo
It has been and interesting week after my first chemo treatment. First, the Benedryl used in the premeds resulted in a hilararous math problem solving discussion with my wife. Received an hour of cabazitaxel and then and hour of carboplatin. At the conclusion, I received a Neulasta shot. So, my experience
It has been and interesting week after my first chemo treatment. First, the Benedryl used in the premeds resulted in a hilararous math problem solving discussion with my wife. Received an hour of cabazitaxel and then and hour of carboplatin. At the conclusion, I received a Neulasta shot. So, my experience
Sixfactorformula
in
Advanced Prostate Cancer
6 years ago
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Polyphenols - Inflammation.
Dietary phytochemicals popularly associated with health benefits often have a polyphenolic structure. Polyphenols invariably have an important protective role in plants - e.g. resveratrol, in the skin of red grapes, protects against fungal attack & damage caused by intense sunlight, while sulforaphane
Dietary phytochemicals popularly associated with health benefits often have a polyphenolic structure. Polyphenols invariably have an important protective role in plants - e.g. resveratrol, in the skin of red grapes, protects against fungal attack & damage caused by intense sunlight, while sulforaphane
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Immunotherapy for Prostate Cancer: Where Do We Go From Here?—PART 1: Prostate Cancer Vaccines
Immunotherapy for Prostate Cancer: Where Do We Go From Here?—PART 1: Prostate Cancer Vaccines http://www.cancernetwork.com/prostate-cancer/immunotherapy-prostate-cancer-where-do-we-go-herepart-1-prostate-cancer-vaccines?rememberme=1&elq_mid=783&elq_cid=46147&GUID=9788B328-44C7-46BA-B5C5-6194C08E4B16
Immunotherapy for Prostate Cancer: Where Do We Go From Here?—PART 1: Prostate Cancer Vaccines http://www.cancernetwork.com/prostate-cancer/immunotherapy-prostate-cancer-where-do-we-go-herepart-1-prostate-cancer-vaccines?rememberme=1&elq_mid=783&elq_cid=46147&GUID=9788B328-44C7-46BA-B5C5-6194C08E4B16
JLS1
in
Advanced Prostate Cancer
6 years ago
Dexamethasone versus prednisone
I have been trying to get my Endocrinologist to adjust the dose of prednisone so that I can take a steroid that is better for my adrenals. Since I have been taking between 8.5 and 9 mg of prednisone I am now to take 6.5 mg of prednisone and 1/2 of 0.5 mg of Dexamethasone. Which to me is 0.25 of dexamethasone
I have been trying to get my Endocrinologist to adjust the dose of prednisone so that I can take a steroid that is better for my adrenals. Since I have been taking between 8.5 and 9 mg of prednisone I am now to take 6.5 mg of prednisone and 1/2 of 0.5 mg of Dexamethasone. Which to me is 0.25 of dexamethasone
Nap1
in
PMRGCAuk
6 years ago
HHD, 30 years+
Hello everyone, I suffer from HHD for more than 30 years. I applied for the disability almost 2 years ago and I do not know at this time if it will be approved. Because I am not allowed to work during this process and I can not get any benefits, even if I am American and can not afford insurance (too
Hello everyone, I suffer from HHD for more than 30 years. I applied for the disability almost 2 years ago and I do not know at this time if it will be approved. Because I am not allowed to work during this process and I can not get any benefits, even if I am American and can not afford insurance (too
Luiede
in
Hailey-Hailey Disease Worldwide Support Community
6 years ago
Dexamethasone steroids and bendamustine chemotherapy
Me partner has follicular low grade non Hodgkin's lymphoma and has also had an aggressive form last year which was treated with chemotherapy and stem cell treatment . He has just been told the lymphoma is active again and has been feeling unwell since January. He has been given 4mg daily dose of dexamethasone
Me partner has follicular low grade non Hodgkin's lymphoma and has also had an aggressive form last year which was treated with chemotherapy and stem cell treatment . He has just been told the lymphoma is active again and has been feeling unwell since January. He has been given 4mg daily dose of dexamethasone
clova
in
Non Hodgkin's Lymphoma Friends
6 years ago
Question help,dexamethasone test
Hi Wondering if anyone can help me ,took dexamethasone last night at 11pm at 12:30pm had 2 pieces of toast and a chocolate bar ,as I finished work late I am now worried I have messed up the test ,which is today at 9am Do you think this will affect the results ,I’m being tested for cortisol ,cushings
Hi Wondering if anyone can help me ,took dexamethasone last night at 11pm at 12:30pm had 2 pieces of toast and a chocolate bar ,as I finished work late I am now worried I have messed up the test ,which is today at 9am Do you think this will affect the results ,I’m being tested for cortisol ,cushings
Luu2018
in
Thyroid UK
6 years ago
dexamethasone suppression test help
Hi I took 1mg of dexamethasone at 11pm, At 12:30pm I then ate 2 pieces of toasts and a chocolate bar !! I now think I’ve messed the test up I’m meant to be going to doctors at 9am for the test Will it affect the blood test much ?? I’m being tested for cushings disease
Hi I took 1mg of dexamethasone at 11pm, At 12:30pm I then ate 2 pieces of toasts and a chocolate bar !! I now think I’ve messed the test up I’m meant to be going to doctors at 9am for the test Will it affect the blood test much ?? I’m being tested for cushings disease
Luu2018
in
Women's Health
6 years ago
Non-PCa Prescription Drugs: Thalidomide / Lenalidomide (Revlimid)
This post was triggered by Dale's post: "Leibowitz Protocol". "Dr. Bob" may have moved on during the intervening 10 years, but I was intrigued by his use of Thalidomide & Lenalidomide to inhibit angiogenesis. Tumors cannot outgrow their blood supply unless they make extensions to existing blood vessel
This post was triggered by Dale's post: "Leibowitz Protocol". "Dr. Bob" may have moved on during the intervening 10 years, but I was intrigued by his use of Thalidomide & Lenalidomide to inhibit angiogenesis. Tumors cannot outgrow their blood supply unless they make extensions to existing blood vessel
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Not sure how to interpret results of new tests
Labs both late or missed PSA this time around. First time tested T and DHT. Look like good results to me, but don't have any experience with them so thought I would throw them out her and see if I am evaluating them right. DHT--<5 L T, total,LC/MS/MS ---7L Due for next Lupron shot Monday. Adding Xtandi
Labs both late or missed PSA this time around. First time tested T and DHT. Look like good results to me, but don't have any experience with them so thought I would throw them out her and see if I am evaluating them right. DHT--<5 L T, total,LC/MS/MS ---7L Due for next Lupron shot Monday. Adding Xtandi
Shooter1
in
Advanced Prostate Cancer
6 years ago
CRPC & Avodart [Dutasteride].
New study below. Some may recall that I'm in favor of shutting off all escape paths while on ADT - e.g. via Zytiga, Casodex, Simvastatin & Avodart. If you are closing the door, close the windows too. The conventional view is that since 5alpha-reductase converts testosterone [T] to dihtdrotestosterone
New study below. Some may recall that I'm in favor of shutting off all escape paths while on ADT - e.g. via Zytiga, Casodex, Simvastatin & Avodart. If you are closing the door, close the windows too. The conventional view is that since 5alpha-reductase converts testosterone [T] to dihtdrotestosterone
pjoshea13
in
Advanced Prostate Cancer
6 years ago
1 week after taking Methotrexate
For the last two months I was on Dexamethasone 4mg and was able to be normal. I could walk, run and even use my hands as before. It was a normal Christmas and New Year. However, my Rheumatologist took me of them. Slowly my RA returned and I am back to square one...with serve joint pains in the hands
For the last two months I was on Dexamethasone 4mg and was able to be normal. I could walk, run and even use my hands as before. It was a normal Christmas and New Year. However, my Rheumatologist took me of them. Slowly my RA returned and I am back to square one...with serve joint pains in the hands
sunnydown
in
NRAS
6 years ago
Medications that are BAD for your bones?
Have you ever taken a moment to read the package insert that comes with your prescription drugs? There are many that can harm your bones. You may need to take one of these medications, but it is extra important to take steps to protect your bones.
Here are the most common medications that can harm
Have you ever taken a moment to read the package insert that comes with your prescription drugs? There are many that can harm your bones. You may need to take one of these medications, but it is extra important to take steps to protect your bones.
Here are the most common medications that can harm
Hidden
in
Osteoporosis Support
6 years ago
New Rheumatologist, but where to now??
I have been reading with great interest whisperits last post on his visit to the sleep consultant and also Twitchy's last CTD appointment. Both just show basically what a mess we are all in with regards to treatment and help as we fall helplessly between all specialities. It is the rare medic who sticks
I have been reading with great interest whisperits last post on his visit to the sleep consultant and also Twitchy's last CTD appointment. Both just show basically what a mess we are all in with regards to treatment and help as we fall helplessly between all specialities. It is the rare medic who sticks
cuttysark
in
LUPUS UK
6 years ago
Latest part of the lung cancer journey .
Last week got admitted to hospital with another seizure caused ? By brachicardia pulse dropped to 35bpm due to ? Cardiac tumour .Anyway good result I have been unwell for several weeks now ,now have a pacemaker and finally feeling a lot better ,still have delayed reaction from stereotactic treatment
Last week got admitted to hospital with another seizure caused ? By brachicardia pulse dropped to 35bpm due to ? Cardiac tumour .Anyway good result I have been unwell for several weeks now ,now have a pacemaker and finally feeling a lot better ,still have delayed reaction from stereotactic treatment
Hidden
in
The Roy Castle Lung Cancer Foundation
7 years ago
Delirium- infection, dexamethasone withdrawal or brain mets?
Hi all This may be a long post as it's been a stressful few days! I am interested to hear of anyone's experience of brain mets? What were the symptoms? My mum who has stage 4 Adenocarcinoma was admitted to hospital on Saturday with confusion and incontinence. She had seemed a bit unwell throughout last
Hi all This may be a long post as it's been a stressful few days! I am interested to hear of anyone's experience of brain mets? What were the symptoms? My mum who has stage 4 Adenocarcinoma was admitted to hospital on Saturday with confusion and incontinence. She had seemed a bit unwell throughout last
MissyD1
in
Lung Cancer Support
7 years ago
Delirium - infection, dexamethasone withdrawal or brain mets??
Hi all This may be a long post as it's been a stressful few days! I am interested to hear of anyone's experience of brain mets? What were the symptoms? My mum who has stage 4 Adenocarcinoma was admitted to hospital on Saturday with confusion and incontinence. She had seemed a bit unwell throughout
Hi all This may be a long post as it's been a stressful few days! I am interested to hear of anyone's experience of brain mets? What were the symptoms? My mum who has stage 4 Adenocarcinoma was admitted to hospital on Saturday with confusion and incontinence. She had seemed a bit unwell throughout
MissyD1
in
The Roy Castle Lung Cancer Foundation
7 years ago
how do you fast before Chemo? I have a drug to take that requires food with it "DEXAMETHASONE" ~~
I told my doctor...that I was going to fast at least 36 hours before and also the day of my chemo and he said it wasn't necessary. I've read so much including from the NIH about how good it is for best results. My question is...I have been given a pill to take 12 hours before and 3 hours before(the dexamethasone
I told my doctor...that I was going to fast at least 36 hours before and also the day of my chemo and he said it wasn't necessary. I've read so much including from the NIH about how good it is for best results. My question is...I have been given a pill to take 12 hours before and 3 hours before(the dexamethasone
greatjohn
in
Advanced Prostate Cancer
7 years ago
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