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Dutasteride increases PSA Doubling Time after PSA Recurrence
These two Kaplan-Meier plots compare Dutasteride (0.5 mg/day) to Placebo in a randomized, double-blind trial from 2012 of 187 men who have progressed to
PSA Failure.
In the upper plot, Dutasteride increases the
Doubling Time
from, for example, 9 months to 18 months (factor of 2X). In
These two Kaplan-Meier plots compare Dutasteride (0.5 mg/day) to Placebo in a randomized, double-blind trial from 2012 of 187 men who have progressed to
PSA Failure.
In the upper plot, Dutasteride increases the
Doubling Time
from, for example, 9 months to 18 months (factor of 2X). In
janebob99
in
Advanced Prostate Cancer
4 months ago
UPDATE
UPDATE Hi folks, I havnt been very active recently - mostly because things were going slowly, but well with my PCA. Ive just had my latest bloodwork which confirms a PCA increase with a doubling time of about 6 months. This is all very standard and to be expected - I am 4.3 years out from PSA of 1000
UPDATE Hi folks, I havnt been very active recently - mostly because things were going slowly, but well with my PCA. Ive just had my latest bloodwork which confirms a PCA increase with a doubling time of about 6 months. This is all very standard and to be expected - I am 4.3 years out from PSA of 1000
Stoneartist
in
Advanced Prostate Cancer
4 months ago
High PSA upon diagnosis, treatment , and outcome
Hello, Diagnosed 9 months ago with Gleason 7 unfavorable… 2 4+3 ,2 3+4, and 1 3+3 ..on one side only ..I guess my high PSA score made it unfavorable , PSA 18. As a result had aggressive tri modality treatment .. brachytherapy seeds, 15 linac radiation sessions, and 9 months o ADT ..just stopped
Hello, Diagnosed 9 months ago with Gleason 7 unfavorable… 2 4+3 ,2 3+4, and 1 3+3 ..on one side only ..I guess my high PSA score made it unfavorable , PSA 18. As a result had aggressive tri modality treatment .. brachytherapy seeds, 15 linac radiation sessions, and 9 months o ADT ..just stopped
Yokohama2023
in
Prostate Cancer Network
4 months ago
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What is role of hormonal therapy drug when taken with targeted therapy, eg Piqray or Ibrance?
I’ve been curious about this and wondering if anyone can explain. I want to better understand the role of the hormone therapy eg Faslodex when taken with targeted therapy such as Ibrance. Does it just reduce the amount of estrogen available to the cell and “lightens the load” on the targeted therapy?
I’ve been curious about this and wondering if anyone can explain. I want to better understand the role of the hormone therapy eg Faslodex when taken with targeted therapy such as Ibrance. Does it just reduce the amount of estrogen available to the cell and “lightens the load” on the targeted therapy?
HelenWi
in
SHARE Metastatic Breast Cancer
10 months ago
Insomnia with new brand of Tamoxifen
I am feeling very sorry for myself at the moment as I am dealing with persistent insomnia on a new generic brand of Tamoxifen. I had been prescribed Nolvadex D and was taking it successfully more or less for 3 and a half years. Unfortunately Nolvadex is no longer being manufactured so I am now taking
I am feeling very sorry for myself at the moment as I am dealing with persistent insomnia on a new generic brand of Tamoxifen. I had been prescribed Nolvadex D and was taking it successfully more or less for 3 and a half years. Unfortunately Nolvadex is no longer being manufactured so I am now taking
Traveller66
in
My Breast Cancer Community
1 year ago
I am scared of colon cancer
hello everyone, I am scared that I might have colon cancer. I have changes in bowel movement . gas and burping that happens after a meal. The other night , I had diarrhea and went to the restroom 3 times within 2 hours. After this, I noticed bloody mucus in the toilet. I also have a gurgling stomach
hello everyone, I am scared that I might have colon cancer. I have changes in bowel movement . gas and burping that happens after a meal. The other night , I had diarrhea and went to the restroom 3 times within 2 hours. After this, I noticed bloody mucus in the toilet. I also have a gurgling stomach
Kvance424
in
Colon Cancer Connected
4 months ago
Is this decision right for me
I had a PSMA pet scan on 7/16/2024. The result shows a single tumor in my left lung measuring 8mm. My MO wants me to have the tumor radiated and monitor the PSA and its doubling time. A little background, I'm just short of 83 years old. I had prostatectomy in 2009, PSA undetectable until 2017. I had
I had a PSMA pet scan on 7/16/2024. The result shows a single tumor in my left lung measuring 8mm. My MO wants me to have the tumor radiated and monitor the PSA and its doubling time. A little background, I'm just short of 83 years old. I had prostatectomy in 2009, PSA undetectable until 2017. I had
old64horn
in
Advanced Prostate Cancer
5 days ago
GRATEFUL
Went to appointment with Radiation Oncologist at Emory St. Joseph's Winship Cancer Center - Dr. Bruce Hershatter. Good guy, no BS, straight shooter. He actually drew it out on a sheet of paper (front & back, back was worse) for me and talked me and my friend through the options (1) and pretty much
Went to appointment with Radiation Oncologist at Emory St. Joseph's Winship Cancer Center - Dr. Bruce Hershatter. Good guy, no BS, straight shooter. He actually drew it out on a sheet of paper (front & back, back was worse) for me and talked me and my friend through the options (1) and pretty much
BCPC
in
Advanced Prostate Cancer
12 days ago
A promising adjuvant for immunotherapy in multiple cancers: PVP-037
Hopefully it will help with prostate as well! https://www.drugtargetreview.com/news/151463/discovery-of-a-promising-agonist-adjuvant/
Hopefully it will help with prostate as well! https://www.drugtargetreview.com/news/151463/discovery-of-a-promising-agonist-adjuvant/
Maxone73
in
Advanced Prostate Cancer
13 days ago
List of drugs by their metastatic prostate cancer cancer fighting properties
I asked ChatGPT to put the following drugs in order of their metastatic prostate cancer cancer fighting properties: Metformin, statins, mebendazole, vitamin C, doxycline, Silymarin and Esomeprazole (Nexium). Here is the answer from ChatGPT: Determining the order of these drugs based on their potential
I asked ChatGPT to put the following drugs in order of their metastatic prostate cancer cancer fighting properties: Metformin, statins, mebendazole, vitamin C, doxycline, Silymarin and Esomeprazole (Nexium). Here is the answer from ChatGPT: Determining the order of these drugs based on their potential
Seasid
in
Advanced Prostate Cancer
14 days ago
Unusual case
Short summary. 79 years old. Surgery 12 years ago on G4+3. Recurrence 3 years later. IMRT and second recurrence 3 years later. No ADT. PSADT 1.5 years and now it's 2.3. Two PSMA scans. First showed nothing. Second showed ill defined area in prostate bed that might be positive. Never had ADT.
Short summary. 79 years old. Surgery 12 years ago on G4+3. Recurrence 3 years later. IMRT and second recurrence 3 years later. No ADT. PSADT 1.5 years and now it's 2.3. Two PSMA scans. First showed nothing. Second showed ill defined area in prostate bed that might be positive. Never had ADT.
npac
in
Advanced Prostate Cancer
14 days ago
Lots of updates to Genetics of Prostate Cancer (PDQ®)–Health Professional Version
Genetics of Prostate Cancer •We updated information on •Executive Summary •Risk Factors for Prostate Cancer •Risk Assessment for Prostate Cancer •Indications for Prostate Cancer Germline Genetic Testing •Genetic Testing Approach for Prostate Cancer •Prostate Cancer Genetics: Screening, Surveillance
Genetics of Prostate Cancer •We updated information on •Executive Summary •Risk Factors for Prostate Cancer •Risk Assessment for Prostate Cancer •Indications for Prostate Cancer Germline Genetic Testing •Genetic Testing Approach for Prostate Cancer •Prostate Cancer Genetics: Screening, Surveillance
KocoPr
in
Advanced Prostate Cancer
18 days ago
EGFR p.L747_T751de
Hi, Dad’s oncologist has stopped the Erlotinib as last scan in Jan showed tumour growth. Private Liquid biopsy result just back, mutation EGFR p.L747_T751de. No treatment offered by NHS, oncologist thinks will be more harmful to dad but how does he know for sure? I read some PubMed data that restarting
Hi, Dad’s oncologist has stopped the Erlotinib as last scan in Jan showed tumour growth. Private Liquid biopsy result just back, mutation EGFR p.L747_T751de. No treatment offered by NHS, oncologist thinks will be more harmful to dad but how does he know for sure? I read some PubMed data that restarting
Adaughter
in
The Roy Castle Lung Cancer Foundation
4 months ago
radiation treatments led to perforated colon?
St. Patrick’s Day I collapsed in pain and was rushed to ER. A CT ABD PE revealed a perforated colon near my rectum, broad internal infection (sepsis) with kidneys and liver shutting down. A life flight, three surgeries later, 3 weeks sedated and immobile in an ICU, and seven weeks in hospital rehabs
St. Patrick’s Day I collapsed in pain and was rushed to ER. A CT ABD PE revealed a perforated colon near my rectum, broad internal infection (sepsis) with kidneys and liver shutting down. A life flight, three surgeries later, 3 weeks sedated and immobile in an ICU, and seven weeks in hospital rehabs
kreg001
in
Advanced Prostate Cancer
20 days ago
radiotherapy
Hi all. My husband is scheduled to have radiotherapy on Wednesday. This will hopefully stop, or at least slow down the cancer growing in his liver. He will also have radiotherapy on a hip bone which has started to cause some pain. Hopefully he will get some relief from this. I think that for now
Hi all. My husband is scheduled to have radiotherapy on Wednesday. This will hopefully stop, or at least slow down the cancer growing in his liver. He will also have radiotherapy on a hip bone which has started to cause some pain. Hopefully he will get some relief from this. I think that for now
Believeit
in
Advanced Prostate Cancer
21 days ago
Radiation after Docetaxel
My dad finished chemo Docetaxel in November 2023. In December his PSA was .61. In February it jumped to 2.3. He went for a PET scan. He went back to the doctor today his PSA jumped to 6. The scan showed that many of the metastasis in his bones shrunk are almost gone. There is one spot in his back that
My dad finished chemo Docetaxel in November 2023. In December his PSA was .61. In February it jumped to 2.3. He went for a PET scan. He went back to the doctor today his PSA jumped to 6. The scan showed that many of the metastasis in his bones shrunk are almost gone. There is one spot in his back that
Jshaw916
in
Advanced Prostate Cancer
4 months ago
I'm 75 years old and during a colonoscopy today, my doctor found 10 precancerous plops and one, malignant-looking mass at the end of colon.
He is confident that it is cancer but doesn't know what stage. He has referred me to a good surgeon, whose office will call me next week to set up an appointment. Meanwhile, he gave me a referral for a "CT scan of chest, abdomen and pelvis with PO & IV Contrast." He wants to see if the cancer has spread
He is confident that it is cancer but doesn't know what stage. He has referred me to a good surgeon, whose office will call me next week to set up an appointment. Meanwhile, he gave me a referral for a "CT scan of chest, abdomen and pelvis with PO & IV Contrast." He wants to see if the cancer has spread
CED48
in
Colon Cancer Connected
4 months ago
Only mouse study, but interesting research on microbiome using astragaloside and scorpion venom
Astragaloside IV-PESV inhibits prostate cancer tumor growth by restoring gut microbiota and microbial metabolic homeostasis via the AGE-RAGE pathwayXujun You, Junfeng Qiu, Qixin Li, Qing Zhang, Wen Sheng, Yiguo Cao, Wei Fu BMC cancer 24 (1), 472, 2024 Background Prostate cancer (PCa) is becoming the
Astragaloside IV-PESV inhibits prostate cancer tumor growth by restoring gut microbiota and microbial metabolic homeostasis via the AGE-RAGE pathwayXujun You, Junfeng Qiu, Qixin Li, Qing Zhang, Wen Sheng, Yiguo Cao, Wei Fu BMC cancer 24 (1), 472, 2024 Background Prostate cancer (PCa) is becoming the
Graham49
in
Advanced Prostate Cancer
28 days ago
Please join us next Tuesday, March 19th for our Small Cell Lung Cancer Treatment Landscape Living Room
Hello, Please join us in our San Carlos office next Tuesday March 19th in person or if you don’t live in the area, you can join us virtually on GO2's YouTube Live channel. We are thrilled to have Jared Weiss, MD, Professor of Medicine, Section Chief of Thoracic and Head/Neck Oncology at University
Hello, Please join us in our San Carlos office next Tuesday March 19th in person or if you don’t live in the area, you can join us virtually on GO2's YouTube Live channel. We are thrilled to have Jared Weiss, MD, Professor of Medicine, Section Chief of Thoracic and Head/Neck Oncology at University
Michelezeh
Partner
in
Lung Cancer Support
4 months ago
2Nd Biopsy in 3+ years of Bone Met
Greetings All, A question about biopsies: Upon PC-stage 4 diagnosis per discovery of pc lesions causing spinal compression in 2020, my husband had a biopsy taken during his back surgery-which showed his already metastatic pc not to be an inherited condition. He went on to radiation of the spinal
Greetings All, A question about biopsies: Upon PC-stage 4 diagnosis per discovery of pc lesions causing spinal compression in 2020, my husband had a biopsy taken during his back surgery-which showed his already metastatic pc not to be an inherited condition. He went on to radiation of the spinal
Lavender22
in
Advanced Prostate Cancer
4 months ago
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