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Rising ALP and declining PSA
Hello. I am on Xtandi as last ditch effort after Zytiga and Pluvicto eventually failed. After starting I have declining PSA but dramatically rising ALP. Any thoughts on what this means? Thanks all.
Hello. I am on Xtandi as last ditch effort after Zytiga and Pluvicto eventually failed. After starting I have declining PSA but dramatically rising ALP. Any thoughts on what this means? Thanks all.
jersy
in
Advanced Prostate Cancer
20 days ago
ADT IS DONE. NEXT?
Lupron and Zytiga will have completed 2 years of each in June. I've read some continue Lupron for 3 years or longer. How do you know how long to take? Monitor testosterone and PSA how often? 2 or 3 months?
Lupron and Zytiga will have completed 2 years of each in June. I've read some continue Lupron for 3 years or longer. How do you know how long to take? Monitor testosterone and PSA how often? 2 or 3 months?
rfgh20
in
Advanced Prostate Cancer
20 days ago
Had Davinci RP w/ LNR 8 Reoccurrence in Bed, PSA Rising 0.77 CANNOT Do Radiation active Crohn Disease / Colitis, What about Cryotherapy?
Please Help Me Out, What Can I Do? After resolving incontinence after RP w/ PLNR (8) on 03/14/2033 Had Davinci Radical Prostatectomy with Lymph Node Removal on 03/14/2023 Only 8 Lymph Nodes Removed, according to operating urologist surgeon that is what he saw to remove I brought onto my team
Please Help Me Out, What Can I Do? After resolving incontinence after RP w/ PLNR (8) on 03/14/2033 Had Davinci Radical Prostatectomy with Lymph Node Removal on 03/14/2023 Only 8 Lymph Nodes Removed, according to operating urologist surgeon that is what he saw to remove I brought onto my team
Shorehousejam
in
Advanced Prostate Cancer
20 days ago
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Diagnosed Prostate cancer late January 2024. Gleason 4+3. Localized inside Prostate. Evaluating all options for treatment and diet.
Diagnosed Prostate cancer late January 2024. Gleason 4+3. Localized inside Prostate. Evaluating all options for treatment and diet.
DoubtingTom2
in
Men's Health Forum
20 days ago
Cancer takes another brave man
My wonderful husband passed away yesterday after fighting the beast for 15 years. Gleason 8 all but one core positive. He was so strong tried so hard, 2 clinical trials radiation, Zytiga, Xofigo, lupron for the entire time. Finally at age 65 his body could take no more, he lost over 40 pounds, no energy
My wonderful husband passed away yesterday after fighting the beast for 15 years. Gleason 8 all but one core positive. He was so strong tried so hard, 2 clinical trials radiation, Zytiga, Xofigo, lupron for the entire time. Finally at age 65 his body could take no more, he lost over 40 pounds, no energy
Judymin
in
Advanced Prostate Cancer
21 days ago
Does this mark the beginning of castration resistance?
Hi all, I have been quietly reading all of your posts and comments in the background since my dad's diagnosis with Stage IV adenocarcinoma (Gleason 9 (4+5)) with distal bone metastases in September 2022. My dad's PSA at diagnosis was 150. He is 64. Since May 2023, dad has been on monthly Degarelix
Hi all, I have been quietly reading all of your posts and comments in the background since my dad's diagnosis with Stage IV adenocarcinoma (Gleason 9 (4+5)) with distal bone metastases in September 2022. My dad's PSA at diagnosis was 150. He is 64. Since May 2023, dad has been on monthly Degarelix
Agh-2022
in
Advanced Prostate Cancer
21 days ago
Diet for ADT
(Duplicate post from Advanced Prostate Cancer). What diet should I be following while on ADT for the next two years? Guidelines from handout sheets are contradictary and unclear. I have been on Orgovyx for almost three months, starting on February 27, 2024. My PSA has dropped from 9.2 to 1.2 to 0.9
(Duplicate post from Advanced Prostate Cancer). What diet should I be following while on ADT for the next two years? Guidelines from handout sheets are contradictary and unclear. I have been on Orgovyx for almost three months, starting on February 27, 2024. My PSA has dropped from 9.2 to 1.2 to 0.9
Worked_the_World
in
Prostate Cancer Network
21 days ago
Diet for duration of ADT?
What diet should I be following while on ADT for the next two years? Guidelines from handout sheets are contradictary and unclear. I have been on Orgovyx for almost three months, starting on February 27, 2024. My PSA has dropped from 9.2 to 1.2 to 0.9. My Gleason Score is 9 in six cores and 6 in one
What diet should I be following while on ADT for the next two years? Guidelines from handout sheets are contradictary and unclear. I have been on Orgovyx for almost three months, starting on February 27, 2024. My PSA has dropped from 9.2 to 1.2 to 0.9. My Gleason Score is 9 in six cores and 6 in one
Worked_the_World
in
Advanced Prostate Cancer
21 days ago
Are endocrinologists of any help after ADT?
After ADT, my MO told me that handling things like Prolia management won't be in her bailiwick. I didn't ask about post-ADT SE's and recovery from same. Hot flashes, low T, BMD loss, and last not least sarcopenia. What is the community's experience with how post-treatment SE's are best handled? Are
After ADT, my MO told me that handling things like Prolia management won't be in her bailiwick. I didn't ask about post-ADT SE's and recovery from same. Hot flashes, low T, BMD loss, and last not least sarcopenia. What is the community's experience with how post-treatment SE's are best handled? Are
Derf4223
in
Advanced Prostate Cancer
22 days ago
Podcast Episode with Abraham Morgentaler, MD about Testosterone and Prostate Cancer
This great podcast, "You are not broken," is by a female urologist, Dr. Kelly Casperson. She often explores misconceptions about hormones. This episode with Dr. Morgentaler takes a fascinating look at the theories about castration and prostate cancer. Spoiler alert: it may shake your confidence in the
This great podcast, "You are not broken," is by a female urologist, Dr. Kelly Casperson. She often explores misconceptions about hormones. This episode with Dr. Morgentaler takes a fascinating look at the theories about castration and prostate cancer. Spoiler alert: it may shake your confidence in the
Chris_Ali
in
Advanced Prostate Cancer
22 days ago
LaRue44
My husband has metastatic prostate cancer. We went through all the treatments including 5 pluvicto treatments. Even though his scan shows improvement in some areas it continues to spread. Maybe this is due to no meds such as Xtandi to stop the spread. I'm trying to get more information by reading people's
My husband has metastatic prostate cancer. We went through all the treatments including 5 pluvicto treatments. Even though his scan shows improvement in some areas it continues to spread. Maybe this is due to no meds such as Xtandi to stop the spread. I'm trying to get more information by reading people's
LaRue44
in
Advanced Prostate Cancer
22 days ago
Protein discovery could help solve prostate cancer drug resistance Date:January 22, 2024 Source:Washington State University
I found this information while researching my husband's PSA rising issues. Found it interesting and want to share. Click on link to read the entire article https://www.sciencedaily.com/ Protein discovery could help solve prostate cancer drug resistance Date: January 22, 2024 Source: Washington
I found this information while researching my husband's PSA rising issues. Found it interesting and want to share. Click on link to read the entire article https://www.sciencedaily.com/ Protein discovery could help solve prostate cancer drug resistance Date: January 22, 2024 Source: Washington
MsHope
in
Advanced Prostate Cancer
23 days ago
Any enzalutamide for chemo?
Tall Allen recently posted about a trial in which taking enzalutamide during docetaxel chemotherapy might help get the PSA down. Abiraterone failed for me recently and I’m re-challenging with docetaxel. I’m based in the UK, and NHS protocol doesn’t allow this. Should I go off -piste and take enzalutimde
Tall Allen recently posted about a trial in which taking enzalutamide during docetaxel chemotherapy might help get the PSA down. Abiraterone failed for me recently and I’m re-challenging with docetaxel. I’m based in the UK, and NHS protocol doesn’t allow this. Should I go off -piste and take enzalutimde
Tonyliv
in
Advanced Prostate Cancer
23 days ago
Oh guys, this one is good for mCRPC: Biologic Drug-Device Combination Immunotherapy Shows Promise for Patients with mCRPC
Just presented at 2024 AACR and used clinically on 15 patients "Of the 13 evaluable patients, 11 experienced an objective response, with five complete responses and six partial responses). The other two evaluable patients had stable disease at the time of data analysis. Six patients experienced mild
Just presented at 2024 AACR and used clinically on 15 patients "Of the 13 evaluable patients, 11 experienced an objective response, with five complete responses and six partial responses). The other two evaluable patients had stable disease at the time of data analysis. Six patients experienced mild
Maxone73
in
Advanced Prostate Cancer
23 days ago
Mums recurrence
My mum found out on Friday her cancer has recurred after 11 months. She will start 2nd line treatment of Carboplatin and Caelyx soon, 6 sessions, 1 every four weeks. Does anyone have any positive stories they can share with me to offer some hope. We are devastated!
My mum found out on Friday her cancer has recurred after 11 months. She will start 2nd line treatment of Carboplatin and Caelyx soon, 6 sessions, 1 every four weeks. Does anyone have any positive stories they can share with me to offer some hope. We are devastated!
Shorty18
in
My Ovacome
23 days ago
Nocturia
Ever since my radiotherapy and brachytherapy 2 months ago I have been suffering nocturia, sometimes being forced awake 5 times a night by a painful call and having little or no product when staggering once again to the toilet for a little dribble. I am now trying to limit the liquid I drink during the
Ever since my radiotherapy and brachytherapy 2 months ago I have been suffering nocturia, sometimes being forced awake 5 times a night by a painful call and having little or no product when staggering once again to the toilet for a little dribble. I am now trying to limit the liquid I drink during the
tunybgur
in
Advanced Prostate Cancer
24 days ago
Robotic wedge lung resection
During my pet scan a lung shadow was reported. Biopsy failed to get tissue but Drs. do not think it is from the stage 2/3 prostate cancer. They recommend a wedge resection via a daVinci mechanism to remove it. I'd like to hear from someone who has had that surgery but since it may be tangential to this
During my pet scan a lung shadow was reported. Biopsy failed to get tissue but Drs. do not think it is from the stage 2/3 prostate cancer. They recommend a wedge resection via a daVinci mechanism to remove it. I'd like to hear from someone who has had that surgery but since it may be tangential to this
Eadgbe
in
Advanced Prostate Cancer
24 days ago
How about eating a healthy snack that might help fight PCa. Lotus seeds (Nelumbo nucifera) also known as makhana contain Neferine, see below
Neferine inhibits proliferation and migration of human prostate cancer stem cells through p38 MAPK/JNK activation Suat Erdogan, Kader Turkekul First published: 11 May 2020 https://doi.org/10.1111/jfbc.13253 Abstract Cancer stem cells (CSCs) are one of the significant causes of cancer treatment failure
Neferine inhibits proliferation and migration of human prostate cancer stem cells through p38 MAPK/JNK activation Suat Erdogan, Kader Turkekul First published: 11 May 2020 https://doi.org/10.1111/jfbc.13253 Abstract Cancer stem cells (CSCs) are one of the significant causes of cancer treatment failure
Graham49
in
Advanced Prostate Cancer
24 days ago
The suppression of Prolactin is required for the treatment of advanced prostate cancer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641560/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641560/
agnut
in
Fight Prostate Cancer
25 days ago
ADT duration for high risk with Cribriform
Hi all, Age 72. In good health. I'd like to get some advice on my case. Should I stop ADT after 12 months? https://bmcurol.biomedcentral.com/articles/10.1186/s12894-022-01145-x I just consulted with my RO. I’ve done 11 of 18 months on Eligard. He wants me to stay the course. He spoke about the possibility
Hi all, Age 72. In good health. I'd like to get some advice on my case. Should I stop ADT after 12 months? https://bmcurol.biomedcentral.com/articles/10.1186/s12894-022-01145-x I just consulted with my RO. I’ve done 11 of 18 months on Eligard. He wants me to stay the course. He spoke about the possibility
Miko710
in
Prostate Cancer Network
25 days ago
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