How about eating a healthy snack that might help fight PCa. Lotus seeds (Nelumbo nucifera) also known as makhana contain Neferine, see below

[Graham49]

Neferine inhibits proliferation and migration of human prostate cancer stem cells through p38 MAPK/JNK activation

Suat Erdogan, Kader Turkekul

First published: 11 May 2020

doi.org/10.1111/jfbc.13253

Abstract

Cancer stem cells (CSCs) are one of the significant causes of cancer treatment failure and metastasis, as they have significant chemo-and radio-resistance leading to tumor recurrence. Here we investigated the possible anticancer properties of neferine, a natural alkaloid, on human prostate cancer (PCa) cells and their stem cells. CD44+ CSCs were isolated from androgen-insensitive PC3 cells by magnetic-activated cell sorting system (MACS). Neferine dose-and time-dependently inhibited the viability of PC3 and CSCs as well as androgen-sensitive LNCaP cells through inducing apoptosis and cell cycle arrest at G1 phase. Neferine was shown to downregulate the expression of Bcl-2 and CDK4, and upregulate caspase 3, clePARP, p21, p27, and p53. The treatment significantly inhibits the migration of CSCs. Neferine induces JNK and p38 MAPK phosphorylation, and downregulates PI3K and NF-ĸβ signaling. In conclusion, neferine may have a therapeutic effect inhibiting the PCa cell proliferation as well as by eliminating CSCs.

Practical applications

Neferine is an alkaloid found in the seed embryo of Nelumbo nucifera and has recently been shown to have anticancer effects on various human cancer cells. More than 90% of cancer-related deaths develop after metastasis, and CSCs are considered to be largely responsible for the cell migration and invasion. It has been shown that treatment of neferine kills not only PCa cells but also CSCs, and may contribute to the prevention of progression of PCa and metastasis by inhibiting cell proliferation and migration.

[85236442968]

Graham9

Interesting.

While I do not advocate Lotus seeds, mostly because I know nothing about them, There is an article on them in the National Library of Medicine,

ncbi.nlm.nih.gov/pmc/articl...

[dhccpa]

Seems like I read a post on The Eden Prescription about lotus.

Haven't tried it yet.

[j-o-h-n]

Yeah, but can you smoke them?

Good Luck, Good Health and Good Humor.

j-o-h-n

[Graham49 in reply to j-o-h-n]

They are often consumed in a popped form like popcorn although they might have some of the effects of stuff that is usually smoked.

According to Pharmeasy: A study by Sugimoto et al. in 2008 showed that bioactive compounds like saponins, flavonoids, alkaloids and tannins may help to reduce anxiety and depression. The alkaloids in lotus seeds may increase the time of sleep. Getting good sleep may help manage depression. However, these studies were conducted on mice. Further studies on humans are required to check if lotus seeds may be beneficial for anxiety and depression.

Also it might help you with the cancer you might get from smoking.

A study by Poornima et al. in 2013 showed that lotus seeds might act against lung cancer.

[Islandboy2021]

Do you think it’s better to eat the seeds or take it as a supplement.

[Graham49 in reply to Islandboy2021]

I think chewing the popped form is quite good because it also satisfies hunger and tastes good. The brand I have got is roasted in olive oil and flavoured with lime and chilli.

I have not tried the supplement, but I guess if you wanted to get a large dose of the alkaloid you would need to take it as a supplement.

[garyjp9 in reply to Graham49]

What brand do you use?

[Graham49 in reply to garyjp9]

Mr Makhana although I will try others.

[garyjp9 in reply to Graham49]

Thanks

[Jpburns]

The land of the lotus eaters…

en.wikipedia.org/wiki/Lotus...