Oh guys, this one is good for mCRPC: Biologic Drug-Device Combination Immunotherapy Shows Promise for Patients with mCRPC

[Maxone73]

Just presented at 2024 AACR and used clinically on 15 patients

"Of the 13 evaluable patients, 11 experienced an objective response, with five complete responses and six partial responses). The other two evaluable patients had stable disease at the time of data analysis. Six patients experienced mild to moderate treatment-related adverse events, including fever, rigors, fatigue, diaphoresis, hematuria, urinary tract infection, acute urinary retention, and hepatic enzyme elevation."

If these data are correct, it's way more than showing promise! Even if the sample was relatively small, we are talking about low cost on location immune therapy for metastatic prostate cancer

aacr.org/about-the-aacr/new...

clinicaltrials.gov/study/NC... this is the trial

[KocoPr]

This sounds similar to Dr Ornik’s therapy.

The only difference is the biological drug cocktail.

What I also like about this trial is it included mHSPC patients that opted out of hormone therapy.

what I would like to see for the next step is to biopsy the tumor just before freezing it and test the tumor in a lab to determine the best cocktail of immune antigens and agonists.

SV-102

investigational multitarget biologic drug called SV-102—which is a fixed-dose drug comprised of active pharmaceutical ingredients: an anti-PD-1 antibody, an anti-CTLA4 antibody, a CD40 agonist, and a TLR9 agonist—is infused into the area of lysis in the tumor.

[pakb]

I wish the results broke out which patients had which responses. Wondering if there was any difference in response for those who had never had ADT vs those who had become castrate resistant.

[Maxone73 in reply to pakb]

12 patients with mCRPC and three patients with metastatic prostate cancer who opted out of hormone therapy...13 were evaluated, 11 had response (5 complete + 6 partial) 2 were stable....we know that for sure one guy without ADT had stable disease as minimum

I need to watch the presentation actually, I suppose they have given out that information about stratification

[Gs-rider]

I really appreciate Your ongoing efforts to report research and studies to this forum. Thank you Maxone73!

[lokibear0803 in reply to Gs-rider]

^^that

[KocoPr]

What he said

[Maxone73]

thanks!!

[traxcavator]

I'm supposed to have something similar at the end of this month. I'll post when there's anything to know.

What we're talking about is Irreversable Electroporosis concurrently with CAR-T cell infusion. Whether the infusion is intratumoral or other hasn't been explained to me.

Having had multiple ablations previously, the amount of tumor ablated correlates fairly well to PSA. From my point of view, if only the ablation is effective, and there is no immune response, that's not a bad result. The next thing would be additional scans, and repeat ablation. Obviously an immune response would be bigger than winning a billion dollar lottery jackpot.

I'll be doing PSA tests fairly often to try to understand what happens. If treatment just causes ablation, I'd expect PSA to drop, and then start going up again (as with previous ablations). If PSA drops, and doesn't go back up, that would seem to be an indication of an immune response.

John

[Maxone73 in reply to traxcavator]

I think also some of the side effect (like fever for example) would be sign of an immune response? (I have never checked if it could be the case)

[traxcavator]

I think it was Hippocrates who said: "No fever, no cure".

Fever is a sign of cytokine release syndrome, which is often associated with immune response. The interleukins were originally called "edogenous pyrogens" because of their fever causing effects.

[Steel67]

I participated in this trial. Not too difficult, sedation/catheterization. 3 treatments one month apart. Final prostate biopsy showed complete resolution of persistent prostate disease. I participated after considering and talking to Dr. Onik. I thought their protocol was more scientific and organized than Dr Oniks- my humble opinion .

Side effects came after 2nd treatment and for 12 weeks were persistent diarrhea and and 4 weeks of joint pain.

My initial treatments for widespread metastatic disease were Orgovyx, Nubeqa and Lu177. SBRT to 3 spots. Now PET PSMA is clear, and attacked persistent glandular disease with this treatment.

I discontinued Orgovyx, but continue Nubeqa. My PSA is now 0.1 and stable, this is up from .04 Nadir when on Orgovyx.

Will continue to monitor and scan and now considering Turbium for mico-Mets or disease undetectable by PET PSMA.

I’ve had good results with this treatment and am optimistic/hopeful for the future.

[Maxone73 in reply to Steel67]

Great news! Keep us updated if you can!

[Steel67 in reply to Maxone73]

Will do