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The role of PSMA PET/CT in predicting downgrading in patients with Gleason score 4+4 prostate cancer in prostate biopsy - W Jour Uro 5/21/24
[i]An interesting investigation aimed at validating the use of PSMA PET/CT in patients to adjust the Gleason score (downward) of their cancer based on conventional pre-surgery biopsy, scans (ultrasound & MRI). In this instance the focus was on downgrading from a high-risk of 8 to an intermediate-risk
[i]An interesting investigation aimed at validating the use of PSMA PET/CT in patients to adjust the Gleason score (downward) of their cancer based on conventional pre-surgery biopsy, scans (ultrasound & MRI). In this instance the focus was on downgrading from a high-risk of 8 to an intermediate-risk
cujoe
in
Fight Prostate Cancer
19 days ago
Clarity's theranostic prostate cancer trial advances to cohort 2
https://finance.yahoo.com/news/claritys-theranostic-prostate-cancer-trial-130300493.html
https://finance.yahoo.com/news/claritys-theranostic-prostate-cancer-trial-130300493.html
Rfs1975
in
Advanced Prostate Cancer
20 days ago
any similar stories extensive metastatic prostate cancer
hello! I’ve been on here for a few weeks reading everyone’s posts, which have been helpful. My dad recently found out he has extensive Mets throughout his skeleton, although we have been battling this disease for almost 5 years now, things have taken a turn. He has been on ADT since January, and tolerating
hello! I’ve been on here for a few weeks reading everyone’s posts, which have been helpful. My dad recently found out he has extensive Mets throughout his skeleton, although we have been battling this disease for almost 5 years now, things have taken a turn. He has been on ADT since January, and tolerating
Concerneddaughter123
in
Advanced Prostate Cancer
20 days ago
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How much targeted radiation to mets?
Hi, Warriors. I've been through Zytiga, Pluvicto and Xtandi - all failed. Have aggressive metastatic cancer and mets head to toe. Starting to get pain in bones and already had one major blast of radiation to ribs. Can they keep blasting spots as they get painful, or is there a radiation limit?
Hi, Warriors. I've been through Zytiga, Pluvicto and Xtandi - all failed. Have aggressive metastatic cancer and mets head to toe. Starting to get pain in bones and already had one major blast of radiation to ribs. Can they keep blasting spots as they get painful, or is there a radiation limit?
jersy
in
Advanced Prostate Cancer
22 days ago
Large Prostate more difficult to remove ?
In 2013 I had robotic prostatectomy. My prostate was quite large, volume 130ml, size 7.43x5.61x5.97cm. As a result, prostate was removed in two pieces, no seminal vesicles where removed and path: "pT2c bilateral, pNx, GL 4+3 Tertiary 5, EPE not identified, SUV not identified". I understand, pNx means
In 2013 I had robotic prostatectomy. My prostate was quite large, volume 130ml, size 7.43x5.61x5.97cm. As a result, prostate was removed in two pieces, no seminal vesicles where removed and path: "pT2c bilateral, pNx, GL 4+3 Tertiary 5, EPE not identified, SUV not identified". I understand, pNx means
Maxi54
in
Advanced Prostate Cancer
22 days ago
Husband getting extremely tired on Zytiga
Tim began Zytiga one month ago. He is also doing Lupron and EBRT which will be over in 5 sessions (he had 5 weeks of them all together). Up until about 5 days ago, he was working and then going to Pilates once a week and to the gym, but now he is coming home EXHAUSTED from work and barely has the energy
Tim began Zytiga one month ago. He is also doing Lupron and EBRT which will be over in 5 sessions (he had 5 weeks of them all together). Up until about 5 days ago, he was working and then going to Pilates once a week and to the gym, but now he is coming home EXHAUSTED from work and barely has the energy
Usernameitis
in
Advanced Prostate Cancer
22 days ago
Has anyone heard of trial DB-1311-O-1001?
Hi all, I’m wondering whether anybody has heard of the above trial? My Dad had been put forward for this and was advised yesterday he got through onto the trial but the paperwork says “first trial on humans”. They aren’t sure of the side effects and we are all feeling a bit apprehensive… My Dad has
Hi all, I’m wondering whether anybody has heard of the above trial? My Dad had been put forward for this and was advised yesterday he got through onto the trial but the paperwork says “first trial on humans”. They aren’t sure of the side effects and we are all feeling a bit apprehensive… My Dad has
Stefciaa
in
Advanced Prostate Cancer
22 days ago
Finally Something’s Working
I have had this mutherf*cker of a disease 19 years. I have had numerous rounds of Lupron. I have been on Casodex, Erleada, Nubeqa. Zytiga, Provenge, 8 rounds of Docetaxel and, now, Pluvicto. As is standard, after my third round of Pluvicto I had a PSMA PET scan. Finally, something seems to be working
I have had this mutherf*cker of a disease 19 years. I have had numerous rounds of Lupron. I have been on Casodex, Erleada, Nubeqa. Zytiga, Provenge, 8 rounds of Docetaxel and, now, Pluvicto. As is standard, after my third round of Pluvicto I had a PSMA PET scan. Finally, something seems to be working
MJCA
in
Advanced Prostate Cancer
22 days ago
How many treatments of Chemo can the body handle
I have had 7 cycles of docetaxel and 3 of cabazitaxel. The oncologist wants to continue with another 7 cycles of cabazitaxel. My question is how much of this poison can the body handle. Does this chemo destroy things permanently in the body. I know that the fatigue is taking over. I couldn't run
I have had 7 cycles of docetaxel and 3 of cabazitaxel. The oncologist wants to continue with another 7 cycles of cabazitaxel. My question is how much of this poison can the body handle. Does this chemo destroy things permanently in the body. I know that the fatigue is taking over. I couldn't run
Islandboy2021
in
Advanced Prostate Cancer
22 days ago
Kindly seeking advice about my options
I'm metastatic HSPCa on Lupron/Erleada over two years now. Three periaortic lymph nodes and two ribs lesions. Sooner or later, I will go metastatic HRPCa (average about 3 years to become hormone resistant). So, my question is what kind of treatment coming next Thanks for your input
I'm metastatic HSPCa on Lupron/Erleada over two years now. Three periaortic lymph nodes and two ribs lesions. Sooner or later, I will go metastatic HRPCa (average about 3 years to become hormone resistant). So, my question is what kind of treatment coming next Thanks for your input
Maxi54
in
Advanced Prostate Cancer
23 days ago
My Cancer Journey Repost
It's time for a repost of my two-part cancer journey diary. Some "starting the journey readers" might find it helpful. Originally posted as two Health Unlocked "replies" - maybe I should make them an actual full "post". So I am pleased to report that
other than fatigue, I feel sort of normal right
It's time for a repost of my two-part cancer journey diary. Some "starting the journey readers" might find it helpful. Originally posted as two Health Unlocked "replies" - maybe I should make them an actual full "post". So I am pleased to report that
other than fatigue, I feel sort of normal right
JohnInTheMiddle
in
Advanced Prostate Cancer
23 days ago
Phase 1/2 of TLX592 Targeted Alpha Therapy in Prostate Cancer starting soon - Ac 225
"The approach accelerates blood clearance and reduces bone marrow residence time compared with standard monoclonal antibodies (mAbs), while retaining target selectivity, internalisation and retention." https://www.prnewswire.com/news-releases/telix-completes-proof-of-concept-study-of-tlx592-targeted-alpha-therapy-in-prostate-cancer
"The approach accelerates blood clearance and reduces bone marrow residence time compared with standard monoclonal antibodies (mAbs), while retaining target selectivity, internalisation and retention." https://www.prnewswire.com/news-releases/telix-completes-proof-of-concept-study-of-tlx592-targeted-alpha-therapy-in-prostate-cancer
Maxone73
in
Advanced Prostate Cancer
23 days ago
Chronic sinus issues
I’m currently on an Xtandi, Zometa and Lupron treatment plan. Could there be a correlation between one of these drugs and chronic sinus stuffiness? I also take a cholesterol drug and 3 different blood pressure meds. Thanks in advance if anyone has information. My Best Jim
I’m currently on an Xtandi, Zometa and Lupron treatment plan. Could there be a correlation between one of these drugs and chronic sinus stuffiness? I also take a cholesterol drug and 3 different blood pressure meds. Thanks in advance if anyone has information. My Best Jim
NDJIM
in
Advanced Prostate Cancer
23 days ago
Ped5i/Tadalafil etc as a benefit to SE of ADT?
Tadalafil , etc is prescribed for ED, BPH and PAH (pulmonary arterial hypertension). It is pretty much agreed upon that Tadalafil increases insulin sensitivity thus improving lean body mass, particularly around the gut, improves Testosterone/estrogen relationship and is good for heart and vascular health
Tadalafil , etc is prescribed for ED, BPH and PAH (pulmonary arterial hypertension). It is pretty much agreed upon that Tadalafil increases insulin sensitivity thus improving lean body mass, particularly around the gut, improves Testosterone/estrogen relationship and is good for heart and vascular health
pj1121
in
Advanced Prostate Cancer
24 days ago
Will Existing Drugs Stop Cancer's Bone Spread? I don't know but it's driving me crazy!
Just because I cannot know which are the two repurposed drugs that seem to have such great results with metastasis. The chief researcher is Neta Erez who has great reputation in research about bone metastasis. I am inclined to think about Ivermectin as one of the possible components of the cocktail,
Just because I cannot know which are the two repurposed drugs that seem to have such great results with metastasis. The chief researcher is Neta Erez who has great reputation in research about bone metastasis. I am inclined to think about Ivermectin as one of the possible components of the cocktail,
Maxone73
in
Fight Prostate Cancer
24 days ago
Is Orgovyx as effective as Lupron/Degarelix ?
My Dad , 83 , with bone mets has started bicalutamide since a week and is soon to take the Lupron shot. But he has a fear of injections as many years back he has developed an abscess due to an injection wrongly given. Is orgovyx as effective as the injections in reducing testesterone ? One doctor
My Dad , 83 , with bone mets has started bicalutamide since a week and is soon to take the Lupron shot. But he has a fear of injections as many years back he has developed an abscess due to an injection wrongly given. Is orgovyx as effective as the injections in reducing testesterone ? One doctor
Tinkudi
in
Advanced Prostate Cancer
24 days ago
Lupron - are there heart risks?
My father , 83 , recently got diagnosed with Prostate cancer with mets to some bones , as per PSMA test. We have not done a biopsy as one doctor said there is no need to do it as treatment options won’t change but another doctor says it’s good to do it in case later down the line we need to add treatments
My father , 83 , recently got diagnosed with Prostate cancer with mets to some bones , as per PSMA test. We have not done a biopsy as one doctor said there is no need to do it as treatment options won’t change but another doctor says it’s good to do it in case later down the line we need to add treatments
Tinkudi
in
Advanced Prostate Cancer
26 days ago
Bayer Starts Phase I Study With Novel Targeted Radionuclide Therapy 225Ac-PSMA-Trillium in Advanced Metastatic Prostate Cancer
225Ac-PSMA-Trillium (BAY 3563254) is an investigational next-generation PSMA-targeted alpha therapy with potential to treat patients with advanced metastatic prostate cancer Prostate cancer is the second most commonly diagnosed cancer in men1, with less than three years median survival among metastatic
225Ac-PSMA-Trillium (BAY 3563254) is an investigational next-generation PSMA-targeted alpha therapy with potential to treat patients with advanced metastatic prostate cancer Prostate cancer is the second most commonly diagnosed cancer in men1, with less than three years median survival among metastatic
God_Loves_Me
in
Advanced Prostate Cancer
27 days ago
Targeting the glutamine metabolism to suppress cell proliferation in mesenchymal docetaxel-resistant prostate cancer
Source Link : https://www.nature.com/articles/s41388-024-03059-4 Docetaxel (DX) serves as a palliative treatment option for metastatic prostate cancer (PCa). Despite initial remission, acquired DX resistance is inevitable. The mechanisms behind DX resistance have not yet been deciphered, but a mesenchymal
Source Link : https://www.nature.com/articles/s41388-024-03059-4 Docetaxel (DX) serves as a palliative treatment option for metastatic prostate cancer (PCa). Despite initial remission, acquired DX resistance is inevitable. The mechanisms behind DX resistance have not yet been deciphered, but a mesenchymal
God_Loves_Me
in
Advanced Prostate Cancer
27 days ago
Drugs and high Calcium
My Oncologist wants me to take Prolia, but the Insurance will not pay for it and wants me to take Zometa. However, I did research on Zometa and its reputation is questionable. What are the alternatives? Xgeva seems better. Any thoughts about this.
My Oncologist wants me to take Prolia, but the Insurance will not pay for it and wants me to take Zometa. However, I did research on Zometa and its reputation is questionable. What are the alternatives? Xgeva seems better. Any thoughts about this.
Poollover
in
Advanced Prostate Cancer
28 days ago
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