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Benign prostatic hyperplasia
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Darolutimide as monotherapy
I know there has been a phase 2 trial (EORTC-GUCG 1532 trial) testing the efficacy of Darolutimide as monotherapy and was wondering if anyone outside of the trial has done this. The phase 2 triall seemed to show that it could be very effective in lowering PSA. Since it doesn't actually stop testosterone
I know there has been a phase 2 trial (EORTC-GUCG 1532 trial) testing the efficacy of Darolutimide as monotherapy and was wondering if anyone outside of the trial has done this. The phase 2 triall seemed to show that it could be very effective in lowering PSA. Since it doesn't actually stop testosterone
RugbyVLS
in
Advanced Prostate Cancer
10 months ago
Alive at Five
Dx Stage IV metastatic PCa with distant metastices to bones and para-aortic lymph node string on July 2, 2018. Still HS and on a year + medication holiday, PSA undetectable. Initially told I had 18 months to live! 🙏
Dx Stage IV metastatic PCa with distant metastices to bones and para-aortic lymph node string on July 2, 2018. Still HS and on a year + medication holiday, PSA undetectable. Initially told I had 18 months to live! 🙏
6357axbz
in
Advanced Prostate Cancer
10 months ago
Docetaxel Update
Hi Gents, I assume this is SOC. I always have a blood draw one day prior to my chemo infusion. Prior to starting Docetaxel, my PSA was 23.6; after 3 rounds, my PSA is 10.7; a decline of 12.9! Yes, the SE are BAD. I have lost all of my hair. My fingernails are discolored, lifting off and sore. I have
Hi Gents, I assume this is SOC. I always have a blood draw one day prior to my chemo infusion. Prior to starting Docetaxel, my PSA was 23.6; after 3 rounds, my PSA is 10.7; a decline of 12.9! Yes, the SE are BAD. I have lost all of my hair. My fingernails are discolored, lifting off and sore. I have
MJCA
in
Advanced Prostate Cancer
10 months ago
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Lupron only after 4.5+ years
I was diagnosed with multiple Mets in August 2018. Started Lupron Nov. 2018. Over the years PSA has bounced up and down from low of 0.5 in March 2021 to high of 1.4 in June 2020. Mostly stayed 0.6 to 0.9. Ended 2022 at .67, but last two readings were 1.01 in March and .98 two days ago. Never had RP,
I was diagnosed with multiple Mets in August 2018. Started Lupron Nov. 2018. Over the years PSA has bounced up and down from low of 0.5 in March 2021 to high of 1.4 in June 2020. Mostly stayed 0.6 to 0.9. Ended 2022 at .67, but last two readings were 1.01 in March and .98 two days ago. Never had RP,
dhccpa
in
Advanced Prostate Cancer
10 months ago
SMALL-CELL NEUROENDOCRINE CARCINOMA
Following prostate cancer first treated with low dose brachytherapy, then ten years later with high dose brachytherapy, from a biopsy following a Turp, I was diagnosed with SMALL-CELL NEUROENDOCRINE CARCINOMA. From a CT scan this was found in my prostate, bladder, and lower colon. I am told that it
Following prostate cancer first treated with low dose brachytherapy, then ten years later with high dose brachytherapy, from a biopsy following a Turp, I was diagnosed with SMALL-CELL NEUROENDOCRINE CARCINOMA. From a CT scan this was found in my prostate, bladder, and lower colon. I am told that it
gegan01
in
Prostate Cancer Network
4 months ago
Progression
My Oncologist says that after 4+ years of ADT, I am showing signs of castrative resistance. He also said that I am currently Low volume, low PSA Oligmatistic. Can someone translate. I had a PSMA scan a couple of weeks ago and the Radiation Oncologist said that I had a positive response. Thanks
My Oncologist says that after 4+ years of ADT, I am showing signs of castrative resistance. He also said that I am currently Low volume, low PSA Oligmatistic. Can someone translate. I had a PSMA scan a couple of weeks ago and the Radiation Oncologist said that I had a positive response. Thanks
NDJIM
in
Advanced Prostate Cancer
8 months ago
Blood work on radiation and Lupron
I am sure this has probably been discussed before but I could not find an answer. How long after initial radiation should you wait to get a valid PSA test? Background Started Lupron 6 weeks prior to radiation and Casodex one week before that to reduce the spike of testosterone. Next week will be my
I am sure this has probably been discussed before but I could not find an answer. How long after initial radiation should you wait to get a valid PSA test? Background Started Lupron 6 weeks prior to radiation and Casodex one week before that to reduce the spike of testosterone. Next week will be my
Mgtd
in
Advanced Prostate Cancer
11 months ago
Use it or lose it - workout questions.
Ok so up front: Gleason 10. Matters? Dunno..castrate resistant now as aberaterone failed. Been battling this since 2020. I was PSA .12 this time last year, started going up at Nov 3-month just, and up since, which was apparent failure point for aberaterone. I had cancer jump into hip, hip muscle,
Ok so up front: Gleason 10. Matters? Dunno..castrate resistant now as aberaterone failed. Been battling this since 2020. I was PSA .12 this time last year, started going up at Nov 3-month just, and up since, which was apparent failure point for aberaterone. I had cancer jump into hip, hip muscle,
DD50
in
Advanced Prostate Cancer
8 months ago
Are PSMA negative mets usually castrate resistant?
I had 2 clear PSMA-PETs (at a PSA of 2 & then 4) so Dr. Scholz recommended I get an FDG PET. Low and behold 3 decent sized mets showed up. In my subsequent research it seems like all the published articles describe the PSMA negative mets as being castrate resistant. Zytiga/Lupron was effective before
I had 2 clear PSMA-PETs (at a PSA of 2 & then 4) so Dr. Scholz recommended I get an FDG PET. Low and behold 3 decent sized mets showed up. In my subsequent research it seems like all the published articles describe the PSMA negative mets as being castrate resistant. Zytiga/Lupron was effective before
V10fanatic
in
Advanced Prostate Cancer
10 months ago
Caffeic acid phenethyl ester [CAPE]
New study [1]. "
Caffeic acid phenethyl ester suppresses EGFR/FAK/Akt signaling, migration, and tumor growth of prostate cancer cells
" There have been 2 dozen CAPE papers these last 20 years. Ten of these specifically mention Akt inhibition. CAPE is found in propolis, which bees use to seal
New study [1]. "
Caffeic acid phenethyl ester suppresses EGFR/FAK/Akt signaling, migration, and tumor growth of prostate cancer cells
" There have been 2 dozen CAPE papers these last 20 years. Ten of these specifically mention Akt inhibition. CAPE is found in propolis, which bees use to seal
pca2004
in
Fight Prostate Cancer
1 year ago
Unmetabolized Estrogen (Depurinated Adducts) How I got PCa and how to prevent and detect it.
3 months before I got diagnosed with PCa in May of 2013 I had been feeling tired with no libido. I will bypass my health care profession system failures as it will take up to much space. In Feb 2012-13 I ordered several tests through Genova Diagnostics (
detox genomic
and
complete male hormone
3 months before I got diagnosed with PCa in May of 2013 I had been feeling tired with no libido. I will bypass my health care profession system failures as it will take up to much space. In Feb 2012-13 I ordered several tests through Genova Diagnostics (
detox genomic
and
complete male hormone
KocoPr
in
Fight Prostate Cancer
1 year ago
Pluvitco
Any input on how long it takes for PSA to start dropping if Pluvitco is going to work?
Any input on how long it takes for PSA to start dropping if Pluvitco is going to work?
Russ506
in
Advanced Prostate Cancer
8 months ago
LT and cyberknife
My PSA went down to .5 from 6.0 after cyberknife. Six months later it is back to 1.0 should I be worried?
My PSA went down to .5 from 6.0 after cyberknife. Six months later it is back to 1.0 should I be worried?
crony
in
Advanced Prostate Cancer
8 months ago
Prostatitis advice
My partner (in his mid 60s) had prostate biopsies (over 60 samples) done in summer 2023. He needed a catheter for many weeks afterwards and was in a lot of pain and passing many blood clots. Over the last year since the biopsies he's had recurrent bouts of slow and intermittent urine flow, now having
My partner (in his mid 60s) had prostate biopsies (over 60 samples) done in summer 2023. He needed a catheter for many weeks afterwards and was in a lot of pain and passing many blood clots. Over the last year since the biopsies he's had recurrent bouts of slow and intermittent urine flow, now having
ConcernedOtherHalf
in
Men's Health Forum
8 months ago
Anyone have experience with Provenge? Especially on PSA tests?
For my history, I was diagnosted with Prostrate cancer in 2018. Now 70 years old. I had Surgery in late 2018 where they removed my prostrate and found cancer in 2 lymph nodes. I have had 2 salvage radiation sessions, which appeared to be successful. I have been on Lupron, essentially since surgery
For my history, I was diagnosted with Prostrate cancer in 2018. Now 70 years old. I had Surgery in late 2018 where they removed my prostrate and found cancer in 2 lymph nodes. I have had 2 salvage radiation sessions, which appeared to be successful. I have been on Lupron, essentially since surgery
Chet48
in
Advanced Prostate Cancer
11 months ago
2 Questions
Background: 45 yo, athletic with no comorbidities. Gleason 9, metastatic with 5 bone mets, node mets, and BRCA2. No surgeries or radiation. I’ve been on ADT since Jan 30, 2023. PSA at time of first Firmagon shot was 78. one month later it at 2nd shot it was 5. On Mar 1, 2023 it was 1.5. started Zytiga
Background: 45 yo, athletic with no comorbidities. Gleason 9, metastatic with 5 bone mets, node mets, and BRCA2. No surgeries or radiation. I’ve been on ADT since Jan 30, 2023. PSA at time of first Firmagon shot was 78. one month later it at 2nd shot it was 5. On Mar 1, 2023 it was 1.5. started Zytiga
revchris77
in
Advanced Prostate Cancer
11 months ago
Hello everyone...
It was in August 2022 that my primary care became alarmed after my PSA returned, and it was 77 plus, that I likewise became alarmed by the fact that I must deal with prostate cancer. As a result, I tried hormone therapy for six months and thought about killing myself if I did not die first from the
It was in August 2022 that my primary care became alarmed after my PSA returned, and it was 77 plus, that I likewise became alarmed by the fact that I must deal with prostate cancer. As a result, I tried hormone therapy for six months and thought about killing myself if I did not die first from the
PC-In-NC
in
Prostate Cancer Network
10 months ago
Diagnostic VS Symtomatic PSA Results
Sometimes my PSA results are labeled “Symptomatic” and sometimes “Diagnostic” are the results comparable?
Sometimes my PSA results are labeled “Symptomatic” and sometimes “Diagnostic” are the results comparable?
6357axbz
in
Advanced Prostate Cancer
10 months ago
Expericence with Xtandi
I had very good results for over a year with no side effects. It was part of a clinical study. My PSA is rising so time to move on to another drug. Good luck to you!
I had very good results for over a year with no side effects. It was part of a clinical study. My PSA is rising so time to move on to another drug. Good luck to you!
PastaMan20
in
Advanced Prostate Cancer
8 months ago
Increase in PSA
Hi, my dad (age 62) was diagnosed with Stage 4 prostate cancer with multiple bone metastases in October 2022. He is also BRCA positive. He received 6 doses of docetaxel which he completed on 1/30/2023 and has also been taking apalutamide daily and eligard injections every 3 months. He just received
Hi, my dad (age 62) was diagnosed with Stage 4 prostate cancer with multiple bone metastases in October 2022. He is also BRCA positive. He received 6 doses of docetaxel which he completed on 1/30/2023 and has also been taking apalutamide daily and eligard injections every 3 months. He just received
Juju0713
in
Advanced Prostate Cancer
11 months ago
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