Poop talk: microbiome and prostate cancer, some news

[Maxone73]

Ok, it's one fascinating subject, especially if we use the word microbiome! Consider that the study was carried out on murine models but also on humans, so there are some interesting findings.

In a small small nutshell (but I suggest you to read the whole article, at least the introduction and the conclusions):

- The study suggests that dietary interventions, particularly those rich in omega-3, could modulate gut microbiota to benefit PCa outcomes.

- There is a significant interaction between the gut microbiome and PCa, influencing tumor growth and progression.

- Understanding the gut microbiome's role could lead to novel therapies that target gut bacteria to manage PCa.

nature.com/articles/s41467-...

[JohnInTheMiddle]

Great share Max! Paper is in Nature Communications (part of the Nature academic complex), apparently written by researchers in Quebec, Canada, so we can consider it serious. The paper was hard to read as a lay person - there was no conclusion.

Would it be correct to say though that the implications of the work documented in the paper is, for lay people, "eating lots of eggs is good for you" if you have metastatic prostate cancer?

I would really like this to be true; I eat a lot of eggs 😂

[Mascouche]

The article is complicated (at least to me) but if I understood, I think it is time to load up on fish and flaxseed

[Aardvark4 in reply to Mascouche]

😍I'm reading it as - fish (oily) yes also eggs (JohnInTheMiddle😍), for long chain fatty acids (LCFA), but not flax seed = SCFA. Basically cut down on Alpha Linolenic Acid (ALA) rich foods; at least, that is until the next bit of groundbreaking research that will say different!

What goes round, comes round...........

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and here I go round! and around!

All too confusing for me

I'm going to lie down now.

night night

[Nomiskneh]

Thanks for sharing this research. I think we have to take gut-influence seriously.

Henk

[vintage42]

I liked this statement -- "It is not clear how PCa could cause steady-state changes in gut microbiota since the prostate and the intestine are anatomically separated."

[CrackerOcala in reply to vintage42]

In essence the radiation process has spillover/collateral damage. Your gut is definitely affected when under radiation - all kinds of bowel stress (diarrhea, constipation, swelling etc.) happen. That's why some oncologists have the patient get a temporary gel barrier placed between the prostate the rectum to try an minimize that. So, YES gut bacteria too will be stressed/harmed. My oncologist said to go on probiotics. Certainly can't hurt.

[vintage42 in reply to CrackerOcala]

The article was about the effect of prostate cancer on gut microbiota. Not about the effect of radiation on the gut.

But on that subject, radiation had no effect on my gut. I had radiation without spacer for prostate, and then radiation for pelvic nodes. Total of 10 weeks, 5 days a week. No effect on the gut.

[Maxone73]

let’s say that the guys who got a Nobel prize for having discovered the relationship between gut microbiome and immune system earned that prize!

[Professorgary]

there was a study done by some med students at JHU several years ago that showed prostate cancer patients with good gut health respond to adt much better than those who have poor gut health. The doctor who reviewed the study suggested fecal transplantation may need to be considered. I have read where advanced prostate cancer patients who eat nuts at least 5 times a week live longer than those who don’t. I always assumed it was because it afforded protection to the heart. I guess there is more to it. So my question is, why are stool samples not taken from cancer patients to be analyzed by conventional doctors but are by naturopathic doctors? Wasn’t it Hippocrates who said all illnes begins in the gut?

[Aardvark4 in reply to Professorgary]

I'm reading this as reducing intake of plant based short chain omega oil ALA contained in nuts and seeds and increase animal based long chain omega oil (3, DHA and EPA)

Had a rethink and I'll continue with my nuts and seeds and change to a microalgae sourced Omega 3 supplement, just on environmental grounds really.

[Sagewiz]

I have read studies that recommend a large variety of probiotics and prebiotics in the diet. Diverse sources count, since they is no list of beneficial gut flora. You just have to have a broad variety and let the gut regulate the balance.

[Maxone73 in reply to Sagewiz]

And different sources of fibers from what I have learned, and a lot of fibers

[Sagewiz]

correct

[Purple-Bike]

I devoured this fascinating study, indicating reduction of prostate cancer progression by intake of Omega3 fats, via gut/pca crosstalk. Powerful. I am further increasing my fat fish intake (herring, mackerel, salmon), to around 1.2 kilos per week as my main protein consumption for almost all meals cooked at home.