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Malecare newsletter reports Finish study glucocorticoids (e.g. prednisone, prednisolone, dexamethasone) can lead to castrate resistance
“However, recent studies have shown that the glucocorticoid receptor also has an oncogenic, or cancer-promoting, effect in cancers like breast and prostate cancer. In prostate cancer, the glucocorticoid receptor can replace the activity of the androgen receptor, which is main oncogenic factor in this
“However, recent studies have shown that the glucocorticoid receptor also has an oncogenic, or cancer-promoting, effect in cancers like breast and prostate cancer. In prostate cancer, the glucocorticoid receptor can replace the activity of the androgen receptor, which is main oncogenic factor in this
Graham49
in
Advanced Prostate Cancer
6 months ago
Waiting for me to die
Just wondering if anyone else has experienced this. Sometimes i get the feeling that friends and family members are waiting for me to die. I was diagnosed stage 4b metastasis in January 2021 and have been on treatment Lupron and Xtandi since April 2021 3 years now. From an outward appearance I don't
Just wondering if anyone else has experienced this. Sometimes i get the feeling that friends and family members are waiting for me to die. I was diagnosed stage 4b metastasis in January 2021 and have been on treatment Lupron and Xtandi since April 2021 3 years now. From an outward appearance I don't
rogerandme
in
Advanced Prostate Cancer
6 months ago
Looking for Encouragement
Hello everyone. Im updating my husband’s profile and hoping to find others that are in a similar situation. He is 62 years old and recently diagnosed with stage IV prostate cancer. His PSA was 885 and has too many Mets to count from his skull to groin area. The urologist started him and casadex and
Hello everyone. Im updating my husband’s profile and hoping to find others that are in a similar situation. He is 62 years old and recently diagnosed with stage IV prostate cancer. His PSA was 885 and has too many Mets to count from his skull to groin area. The urologist started him and casadex and
Iber
in
Advanced Prostate Cancer
1 month ago
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How does Lynparza work?
I am brca2+ and 3 months into Lynparza. Stopped Zytiga, continuing ADT. I generally tolerate meds ok, but am finding this one v toxic. As I understand it, the brca2 gene mutation is in all cells, not just cancerous ones. In this case, Lynparza could be preventing parp from getting to healthy cells
I am brca2+ and 3 months into Lynparza. Stopped Zytiga, continuing ADT. I generally tolerate meds ok, but am finding this one v toxic. As I understand it, the brca2 gene mutation is in all cells, not just cancerous ones. In this case, Lynparza could be preventing parp from getting to healthy cells
Ian99
in
Advanced Prostate Cancer
1 month ago
The steroid with zytiga can be a deal
My Dads new oncologist switched his steroid from prednisolone to dexamethasone - she was distressed at first appointment to see he was on zytiga and prednisolone. She said research pretty clear that dexamethasone is better. On today's PSA results she is clearly correct. We thought that he had become
My Dads new oncologist switched his steroid from prednisolone to dexamethasone - she was distressed at first appointment to see he was on zytiga and prednisolone. She said research pretty clear that dexamethasone is better. On today's PSA results she is clearly correct. We thought that he had become
TomsD1
in
Advanced Prostate Cancer
1 month ago
Does the acute kidney injury mislead the PSA number?
I am doing clinical trials - ARX517. I think i have its side effect that include protein in urine, pulse in urine and also creatine level is up clinical trials update here : https://healthunlocked.com/advanced-prostate-cancer/posts/150713089/nct04662580-all-about-arx517-as-monotherapy Question is
I am doing clinical trials - ARX517. I think i have its side effect that include protein in urine, pulse in urine and also creatine level is up clinical trials update here : https://healthunlocked.com/advanced-prostate-cancer/posts/150713089/nct04662580-all-about-arx517-as-monotherapy Question is
God_Loves_Me
in
Advanced Prostate Cancer
1 month ago
Decision Time
Hi All, I recently posted with my situation and have a follow-up (final I hope) with Dr. Gorovets at MSK to finalize my non-surgical treatment plan. Just looking for any input, thoughts, advice. Greatly appreciated as always. I'm 60, GS 4+3, PSA 5.5, Decipher .55, clean PSMA Pet (full details in
Hi All, I recently posted with my situation and have a follow-up (final I hope) with Dr. Gorovets at MSK to finalize my non-surgical treatment plan. Just looking for any input, thoughts, advice. Greatly appreciated as always. I'm 60, GS 4+3, PSA 5.5, Decipher .55, clean PSMA Pet (full details in
MrGreenJeans
in
Prostate Cancer Network
1 month ago
Abiraterone plus dexa, Lupron, Erleada
Question: Will adding Erleada , already taking these 2 drugs (not counting dexa) Abiraterone plus dexa and Quartely lupron injections increase overall survival? triplet, Right now treatment is Abi & Lupron. I'm high volume metastatic. Slowly rising PSA as of July 1.2. When PSA over 2 or fast doubling
Question: Will adding Erleada , already taking these 2 drugs (not counting dexa) Abiraterone plus dexa and Quartely lupron injections increase overall survival? triplet, Right now treatment is Abi & Lupron. I'm high volume metastatic. Slowly rising PSA as of July 1.2. When PSA over 2 or fast doubling
wolverine11
in
Advanced Prostate Cancer
1 month ago
What’s Next?
My bio illustrates my long 19 year journey with this disease. I turned out to be a great candidate for Pluvicto. All was going well. After cycle 3, a PSMA-PET showed all but one metastases were receding or dead. My PSA before cycle 4 was 17.7. My PSA before cycle 5 was 33.15. Due to the fast increase
My bio illustrates my long 19 year journey with this disease. I turned out to be a great candidate for Pluvicto. All was going well. After cycle 3, a PSMA-PET showed all but one metastases were receding or dead. My PSA before cycle 4 was 17.7. My PSA before cycle 5 was 33.15. Due to the fast increase
MJCA
in
Advanced Prostate Cancer
1 month ago
New insight into combating drug-resistant prostate cancer
https://www.sciencedaily.com/releases/2024/04/240410112742.htm?utm_medium=email&utm_source=rasa_io&utm_campaign=newsletter Is there a currently available way to apply this treatment concept? New research sheds light on the significance of the glucocorticoid receptor in drug-resistant prostate cancer
https://www.sciencedaily.com/releases/2024/04/240410112742.htm?utm_medium=email&utm_source=rasa_io&utm_campaign=newsletter Is there a currently available way to apply this treatment concept? New research sheds light on the significance of the glucocorticoid receptor in drug-resistant prostate cancer
GeorgeGlass
in
Advanced Prostate Cancer
6 months ago
What does it mean?
I'm slightly embarrassed to be asking strangers on the internet, but I'm a little frustrated by the lack of information given by the doctors. My dad (63) just got diagnosed - Gleason score 8 - and after a new scan they've concluded there's two mets - one in the pelvic lymph node and one in the seminal
I'm slightly embarrassed to be asking strangers on the internet, but I'm a little frustrated by the lack of information given by the doctors. My dad (63) just got diagnosed - Gleason score 8 - and after a new scan they've concluded there's two mets - one in the pelvic lymph node and one in the seminal
TerribleAtInternet
in
Advanced Prostate Cancer
6 months ago
Zytiga & prednisone.
Hello Everyone, This is about my Father, he was on Nubeqa and Eligard shot for last two years. His PSA started going up again and his pains also started. His medical oncologist changed his Oral drug to Zytiga with prednisone. He is told not to eat anything two hours before and one hour after Zytiga
Hello Everyone, This is about my Father, he was on Nubeqa and Eligard shot for last two years. His PSA started going up again and his pains also started. His medical oncologist changed his Oral drug to Zytiga with prednisone. He is told not to eat anything two hours before and one hour after Zytiga
Szdnizam3
in
Advanced Prostate Cancer
2 months ago
Too Many Black Men Dying From Prostate Cancer
No matter what you think about OJ Simpson, you all must agree that too many Black men are dying from prostate cancer. Prostate cancer kills Black men at over 2.4 times the rate that it kills White men. If you want to do something, even if you only have 30 seconds a year and no money to donate, sign
No matter what you think about OJ Simpson, you all must agree that too many Black men are dying from prostate cancer. Prostate cancer kills Black men at over 2.4 times the rate that it kills White men. If you want to do something, even if you only have 30 seconds a year and no money to donate, sign
Darryl
Partner
in
Advanced Prostate Cancer
6 months ago
How long can I delay my Lupron shot ?
I am a stage 4 PC patient diagnosed in August 2021 and have been on ADT double therapy ever since.I get Lupron shots every 3 months and take 2 tablets of Apalutamide (Erleada ) evey day. I have been lucky that I responded well to the treatment and have been undetectable ever since. I
I am a stage 4 PC patient diagnosed in August 2021 and have been on ADT double therapy ever since.I get Lupron shots every 3 months and take 2 tablets of Apalutamide (Erleada ) evey day. I have been lucky that I responded well to the treatment and have been undetectable ever since. I
mynacho
in
Advanced Prostate Cancer
2 months ago
looking for next steps for my young husband
Out of desperation I am writing this -we are looking for nothing short of a miracle. My husband was diagnosed in 2021 at age 45 with Stage 4 Prostate Cancer. We have 3 small children ages 7,3 and 2 and we need something to give my husband time with his family. Sharing our journey in hopes that it can
Out of desperation I am writing this -we are looking for nothing short of a miracle. My husband was diagnosed in 2021 at age 45 with Stage 4 Prostate Cancer. We have 3 small children ages 7,3 and 2 and we need something to give my husband time with his family. Sharing our journey in hopes that it can
shaunaliz15
in
Advanced Prostate Cancer
6 months ago
bone Mets!
it’s here. After 11 1/2 years on zoladex injections and Xtandi followed by Nubeqa, husband had a PET scan that shows numerous spots on spine, breastbone and one lymph node in groin. PSA was undetectable for years, then .1 and .2, which triggered the order for the scan. The PA told him he has 1-2years
it’s here. After 11 1/2 years on zoladex injections and Xtandi followed by Nubeqa, husband had a PET scan that shows numerous spots on spine, breastbone and one lymph node in groin. PSA was undetectable for years, then .1 and .2, which triggered the order for the scan. The PA told him he has 1-2years
Nubeqa22
in
Advanced Prostate Cancer
2 months ago
zytiga/pred treatment
please tell me the psa results once you started this combo and the drop in psa over time, does it take months before psa drops or does or should it happen quickly? mine was at 55.2 down to 38.3 then 39.4 in past two months so sm now wondering as tal thought, I am too late to start this combo? I do
please tell me the psa results once you started this combo and the drop in psa over time, does it take months before psa drops or does or should it happen quickly? mine was at 55.2 down to 38.3 then 39.4 in past two months so sm now wondering as tal thought, I am too late to start this combo? I do
billyboy3
in
Advanced Prostate Cancer
2 months ago
Heading to Oncologist for 3month testing and tratment
Heading to Dr. for my quarterly shot of Eligard. I am also on apalutamide as part of a two year trial . I am a year and a half into treatments, including Brachytherapy and EBRT. I have tested < .04 psa for 6 months now despite initial diagnosis of Gleason 9. Everything seems to be gong according to
Heading to Dr. for my quarterly shot of Eligard. I am also on apalutamide as part of a two year trial . I am a year and a half into treatments, including Brachytherapy and EBRT. I have tested < .04 psa for 6 months now despite initial diagnosis of Gleason 9. Everything seems to be gong according to
68Guitar
in
Advanced Prostate Cancer
2 months ago
First PSMA PET scan and aftermath
My oncologists (medical and radiation) had been pushing me to have a PSMA scan for two years. Even though in 2023 my PSA rose from .67 to 1.37, I pointed out that a PSMA scan would not change my treatment. We ran another Axumin PET in January, which was stable, if not better, than the one in September
My oncologists (medical and radiation) had been pushing me to have a PSMA scan for two years. Even though in 2023 my PSA rose from .67 to 1.37, I pointed out that a PSMA scan would not change my treatment. We ran another Axumin PET in January, which was stable, if not better, than the one in September
dhccpa
in
Advanced Prostate Cancer
2 months ago
PSA after one month on lupron
I am 63 with high risk PCa. I was diagnosed with PSA of 30 and Gleason 9 in December. Biopsy and MRI showed all 12 cores malignant with "likelihood of extra-capsular extension". PSMA PET scan showed no mets as of December 15. I began treatment on February 26 with a week of Casodex followed by a Lupron
I am 63 with high risk PCa. I was diagnosed with PSA of 30 and Gleason 9 in December. Biopsy and MRI showed all 12 cores malignant with "likelihood of extra-capsular extension". PSMA PET scan showed no mets as of December 15. I began treatment on February 26 with a week of Casodex followed by a Lupron
CavScout
in
Advanced Prostate Cancer
6 months ago
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