New insight into combating drug-resistant prostate cancer

[GeorgeGlass]

sciencedaily.com/releases/2...

Is there a currently available way to apply this treatment concept?

New research sheds light on the significance of the glucocorticoid receptor in drug-resistant prostate cancer, showing that the development of drug resistance could be prevented by limiting the activity of coregulator proteins.

[Amg1952]

this is very interesting, and you’ve led me down a rabbit hole, so thank you! Some of these EP300/CREBBP inhibitors are already on trial for acute myeloid leukemia. Fascinating!

I will check and see if there are any for PCa but the papers I was reading were fairly new and still in cell line study, that is to say, not yet clinical trial for PCa, specifically still in cell lines. That being said, definitely looks promising interestingly it still seemed to have an effect on the FOX1A as well. Truly hope this is a burgeoning area and potentially a new pathway to examine.

I wonder if any folks at NCI are looking into this

[GeorgeGlass in reply to Amg1952]

yes, Amg. Very interesting and potentially promising. Not sure about NCI. My frustration with breakthrough ideas is that nci and others show good study results from time to time, but nobody takes the findings and mass produces the product/medicine needed. Usually they have too low of a monetary incentive. Let us know if you find more info on it. My research time has been limited lately and I’ve been trying to determine why i started have night sweats 3-4 weeks ago.