please tell me the psa results once you started this combo and the drop in psa over time, does it take months before psa drops or does or should it happen quickly?
mine was at 55.2 down to 38.3 then 39.4 in past two months so sm now wondering as tal thought, I am too late to start this combo?
I do not want to waste yet more time if zytiga is not going to work as I already lost 8 months to get started in this drug change!
Thanks boys!!!
REMEMBER TO LIVE LARGE !!
At biochemical recurrence following RP (Gleason 9, Stage 3b), after one year, my husband became detectable in with doubling at low levels of only one month. At a PSA of .273, a few subcentimeter retrocaval (lower back abdominal area) nodes were moderately avid on PSMA Pet Scan. He was immediately started on Casodex/Lupron. Then two weeks later, dropped Casodex and began Abiraterone/Prednisone combined with Lupron. After only one month, he dropped from 0.273 to <0.001. It worked fast. He was a super responder. We radiated the nodes, as well as salvage IMRT to the pelvis and pray we bought him lots of time. The avid nodes melted away at the end of the IMRT. He had an immediate response to the ADT, but it is my understanding that it can take a bit longer if a patient still has an intact prostate.
Hello Billyboy3, I don't have the specific information in front of me at this point. But I have been on Zytiga, prednisone and Lupron as a combo for at least 6 years. Zytiga was gradual but PSA always going down, I've been undetectable for some years. My prostate wasn't operated on and I have cancer in the lymph nodes.
Before that I was on other drugs, each of which failed. With respect what time have you to waste, while waiting to see if this combination works, its never too late to try another, it might be the wonder drug you've been waiting for.
Your PSA is heading in the right direction 👍. That in itself is very encouraging, I would be focusing on that and looking at the future.
Hang on in there our brother and give your combination some time to get to work.
All the best 💪
Thanks, the side effects are major as compared to my 26 years of IHT
I had some nasty side effects with every treatment. If it helps the ones I had with Zytiga diminished over time, what side effects are you getting 🤔
Hi Lettuce231. I have one question, did you also do radiation?
No, I took a second opinion after diagnosis, he recommended radiation, the original oncologist didn't want to use that. He preferred to start with Lupron, plus the rest until I ended up on Lupron, Zytiga and prednisone. The rational was to use radiation if needed. I don't know if it would have made any difference, I'm this far in without having had that. A good friend of mine had radiation and the beast returned.
Hope this helps you.
My husband was diagnosed with Stage 4, Gleason 9 metastatic prostate cancer in November. Advanced and incurable, but treatable. After initial Rx of Casodex and one Eligard injection, he met with his medical oncologist who changed him to Zytiga (abiraterone) and prednisone. And he has an Eligard injection every 3 months. He also had 28 IMRT radiation treatments. After that his PSA was undetectable. He had a repeat PSA three months later and it was still the same-undetectable. So, it looks like he’s responding favorably to the ADT/ARPI. And maybe the radiation helped, as well. He’s going to stay on this regimen until he becomes castration resistant or his PSA starts rising. But he takes it a day at a time and has a very upbeat, positive attitude. We sure hope he can get a lot of mileage out of Zytiga and Eligard.
Great news. Just stay vigilant and I would do monthly psa tests!!
I'm stage 4 with bone mets. No prostate removal due to mets. My PSA was 12 when I started Aberaterone, Prednisone and Luprin 14 months ago. PSA down to 0.091 at last blood test a month ago. Hate the side effects, but it's keeping the beast at bay for now.
"zytiga/pred... please tell me the psa results once you started this combo and the drop in psa over time..."
I would think Zytiga is more often taken with ADT than alone. That's what I did so cannot tell the effect of Zytiga alone.
16 Nov 2023 3.78 Recurrent after prostate and pelvic radiations in 2021 and 2023
11 Dec 2023 Began Orgovyx (relugolyx) ADT
08 Jan 2024 0.38
03 Feb 2024 Added Zytiga (abiraterone) ARPI
18 Mar 2024 0.11
01 Apr 2024 0.04
22 Jul 2024 0.02
My PSA was at 466 this past February when I started my regimen. First, was a shot of degarelix in the belly. PSA was down to roughly 3.7 after 1 month. Then started on prednisone and Zytiga with a 6 month Lupron shot and the following month PSA was undetectable and it's still undetectable. Next Lupron shot is this September. Side effects have been some modest fatigue, muscle loss and plenty of hot sweats. All are tolerable considering the alternative.
Try 3 monthly shots of Lupron, it might help ease some of the side effects. You're doing well 👏 Over the years my sweats have disappeared, walking helps build the stamina up gradually.
My PSA on 11/22/23 was 1.1, and on 12/8/23 it was 1.5. I started Abiraterone plus Prednisone on Dec. 6, 2023. My PSA on Jan 23 the PSA was undetectable. Side effects were mild hot flashes, some less stamina, testosterone went to zero. I stopped the two medications on June 6, 2024 for a holiday. Testosterone bounced pretty quick. My PSA on July 6 was 0.21, more to follow
thanks guys. My psa has not dropped in the two months so my question was how long you were on both until you had a decrease in psa after starting zytiga/pred?
Have you had radiation at all? My husband finished radiation on March 11 and had been on Zytiga/ prednisone and Eligard injections since December. His first repeat PSA test was in April and it was undetectable. That’s 4 months on the hormone therapy. He just had another one drawn yesterday and it was still the same—undetectable. I’m sure it’s the ADT/ARPI that has kept it down more than the radiation.
No radiation
yes 26 years and counting!!
No radiation
Only on IHT
took monthly Luprin as no test results that the longer duration shots actudy worked the further out you got from injection day!!
We have chased the drug maker fined it came out in 1993, they refuse to provide us any studies to prove 6 months or longer was still offering same level as my monthly shots!
Common sense would SAY NO WAY this drug will work as well the longer between shots.
Big guys like me can small guys, age, metabolism, diet, activity, all will impact the effectiveness of Lupron over time.
I have done monthly for 26 years and do NOT REGRET MY CHOICE!
It is to inject into belly fat so I do most of my shots, get 3 or 4 and keep in my fridge and injection day, warm up, mix and jab!! Fast and easy and keeps you away from the hospital! Costs more but what is your life worth boys !!???
Zytiga after nearly four months
Zytiga
Xtandi to Zytiga 
Zytiga and ADT 
Does Zytiga work or not?
