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Addition of Metastasis-Directed Therapy to Intermittent Hormone Therapy for Oligometastatic PC. The EXTEND Phase 2 Randomized Clinical Trial
MDT and intermittent ADT offer a progression free survival advantage when compared with intermittent ADT alone. "MDT facilitated a longer time with eugonadal testosterone as part of an intermittent hormone therapy strategy." "Time to new lesion failure was longer for patients randomized to combined
MDT and intermittent ADT offer a progression free survival advantage when compared with intermittent ADT alone. "MDT facilitated a longer time with eugonadal testosterone as part of an intermittent hormone therapy strategy." "Time to new lesion failure was longer for patients randomized to combined
tango65
in
Advanced Prostate Cancer
1 year ago
stay positive….
Hi everyone. After having A.Fib for almost two years I had a cardioversion done on the 15 Dec last supported by six months on Amiodarone. My heart rate is now in Normal Sinus Rhythm and so far all's good. Had the Bisoprolol reduced from 3.75 twice a day to 1.25 twice a day and feel a lot more comfortable
Hi everyone. After having A.Fib for almost two years I had a cardioversion done on the 15 Dec last supported by six months on Amiodarone. My heart rate is now in Normal Sinus Rhythm and so far all's good. Had the Bisoprolol reduced from 3.75 twice a day to 1.25 twice a day and feel a lot more comfortable
Ellie-Ann
in
AF Association
1 year ago
Travelling with Afib
Hello all. I've had 3 episodes of paroxysmal afib, each time reverting back to sinus rythym in a few hours. I've had a normal 24hr monitor and echocardiogram, but I do have pre-existing CAD with 5 stents. Since the 1st episode I've taken edoxoban and my bisoprolol has been increased from 5mg to 6.25mg
Hello all. I've had 3 episodes of paroxysmal afib, each time reverting back to sinus rythym in a few hours. I've had a normal 24hr monitor and echocardiogram, but I do have pre-existing CAD with 5 stents. Since the 1st episode I've taken edoxoban and my bisoprolol has been increased from 5mg to 6.25mg
Tab1966
in
Atrial Fibrillation Support
1 year ago
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Statins
I just finished watching - https://www.youtube.com/watch?v=0MSNUjQt0u0 I find it fascinating that doctors are aware that statins don't work on dialysis patients, even the KDIGO guidelines say not to prescribe them, and yet doctors still will go ahead and lower LDL using statins. I know I am on one .
I just finished watching - https://www.youtube.com/watch?v=0MSNUjQt0u0 I find it fascinating that doctors are aware that statins don't work on dialysis patients, even the KDIGO guidelines say not to prescribe them, and yet doctors still will go ahead and lower LDL using statins. I know I am on one .
bumblebee_tuna
in
Kidney Dialysis
1 year ago
Bipolar Androgen Therapy Followed by Androgen Receptor Inhibition as Sequential Therapy for Prostate Cancer
Here's a treat - a review of BAT (Bipolar Androgen Therapy), actually written by Dr. Sam Denmeade [1]. In his intro, he makes a point of stressing that androgen receptor axis therapies are "highly effective [i]
palliative
[/i] therapy, but they are
not curative
." A few years ago it was
Here's a treat - a review of BAT (Bipolar Androgen Therapy), actually written by Dr. Sam Denmeade [1]. In his intro, he makes a point of stressing that androgen receptor axis therapies are "highly effective [i]
palliative
[/i] therapy, but they are
not curative
." A few years ago it was
pjoshea13
in
Fight Prostate Cancer
1 year ago
Clinical Trial with BGB-11417
Hi all! Would love to hear from anyone who is participating in / has considered and/or has knowledge of the NCT trial 04277637 - the Non-Randomized, Open-Label trial investigating the novel BCL-2 inhibitor BGB-11417? I am approaching my first treatment for CLL and my CLL specialist is a PI in this
Hi all! Would love to hear from anyone who is participating in / has considered and/or has knowledge of the NCT trial 04277637 - the Non-Randomized, Open-Label trial investigating the novel BCL-2 inhibitor BGB-11417? I am approaching my first treatment for CLL and my CLL specialist is a PI in this
Chi-town_Girl
in
CLL Support
1 year ago
Full Blood Count Test Results
Hiya, I’ve had a lot of help on this forum in regards to making some sense of my thyroid blood test results and I was wondering if anyone is able to advise with these results too. They are out of date as they are from December 2022 but they are the tests I was given when my hypothyroid symptoms started
Hiya, I’ve had a lot of help on this forum in regards to making some sense of my thyroid blood test results and I was wondering if anyone is able to advise with these results too. They are out of date as they are from December 2022 but they are the tests I was given when my hypothyroid symptoms started
NiaJayne
in
Thyroid UK
1 year ago
How do I stop Afib just after OHS
Hi guys, just wanted to let you know that I’ve had my OHS and to pick your brains please. The op went well and here’s the but…….. I also have a pacemaker and it was set low on 60+ since May 21. Had no probs. During this surgery they raised the PM rate to 75+ After this surgery I’ve been in Afib!
Hi guys, just wanted to let you know that I’ve had my OHS and to pick your brains please. The op went well and here’s the but…….. I also have a pacemaker and it was set low on 60+ since May 21. Had no probs. During this surgery they raised the PM rate to 75+ After this surgery I’ve been in Afib!
Sally_Scott
in
Atrial Fibrillation Support
1 year ago
Involvement Opportunity - PRaCTicAL Research Project (UK)
The British Liver Trust are excited to be working with NHS Lothian, University of Edinburgh, Scottish National Blood Transfusion Services (SNBTS) and Cell and Gene Therapy Catapult as part of a collaboration to create the first ‘Centre for Precision Cell Therapy for the Liver’ in the world. PRaCTicAL
The British Liver Trust are excited to be working with NHS Lothian, University of Edinburgh, Scottish National Blood Transfusion Services (SNBTS) and Cell and Gene Therapy Catapult as part of a collaboration to create the first ‘Centre for Precision Cell Therapy for the Liver’ in the world. PRaCTicAL
BritishLiverTrust1
Partner
in
British Liver Trust
1 year ago
Iron regulation offers new treatment hope for incurable blood cancer
Published April 4, 2023 | Originally published on MedicalXpress Breaking News-and-Events A landmark discovery linking iron regulation to a rare blood cancer has led to clinical trials of a potential new treatment for patients with the incurable disease. The study focused on polycythemia vera (PV),
Published April 4, 2023 | Originally published on MedicalXpress Breaking News-and-Events A landmark discovery linking iron regulation to a rare blood cancer has led to clinical trials of a potential new treatment for patients with the incurable disease. The study focused on polycythemia vera (PV),
PhysAssist
in
MPN Voice
1 year ago
Study says orchiectomy has higher risks for fracture than chemical castration. I wonder why.
https://www.empr.com/home/news/prostate-cancer-adt-increases-bone-fracture-risk/?utm_medium=email&utm_source=rasa_io&utm_campaign=newsletter
https://www.empr.com/home/news/prostate-cancer-adt-increases-bone-fracture-risk/?utm_medium=email&utm_source=rasa_io&utm_campaign=newsletter
rsgdmd
in
Advanced Prostate Cancer
1 year ago
Atrial Tachycardia ablation
Has anyone here had an ablation for atrial tachycardia after they’ve had afib ablations? I’m curious to know if that ablation was any different than your afib ablation? I’ve had 3 afib ablations and it seems they’ve resolved the afib and flutter (knock on wood). But they’ve left me with more regular
Has anyone here had an ablation for atrial tachycardia after they’ve had afib ablations? I’m curious to know if that ablation was any different than your afib ablation? I’ve had 3 afib ablations and it seems they’ve resolved the afib and flutter (knock on wood). But they’ve left me with more regular
lovetogarden
in
Atrial Fibrillation Support
1 year ago
PSA fluctuations on docetaxel?
Hello all, is it normal for the PSA to increase and decrease while on docetaxel? Dad’s enrolled in a clinical trial and is receiving chemotherapy (docetaxel). His PSA was declining but suddenly increased to 1.26 two cycles/doses ago, and to 1.39 last cycle/dose. Wondering if this is indicating his cancer
Hello all, is it normal for the PSA to increase and decrease while on docetaxel? Dad’s enrolled in a clinical trial and is receiving chemotherapy (docetaxel). His PSA was declining but suddenly increased to 1.26 two cycles/doses ago, and to 1.39 last cycle/dose. Wondering if this is indicating his cancer
PHnerd
in
Advanced Prostate Cancer
1 year ago
A question on BP
I am on Nebivolol 5mg for the last 2 months. I take my BP reading about 2 times a day and have watched my pressure go down. I hadn’t had a AFib episode in over a month since on the meds. Night before last, my BP was 114/59. I then became worried it was too low, and couldn’t fall asleep. Once
I am on Nebivolol 5mg for the last 2 months. I take my BP reading about 2 times a day and have watched my pressure go down. I hadn’t had a AFib episode in over a month since on the meds. Night before last, my BP was 114/59. I then became worried it was too low, and couldn’t fall asleep. Once
Peacefulneedshelp
in
AF Association
1 year ago
BTK Inhibitor Therapy for CLL: An International Perspective - Stephan Stilgenbauer, MD
BTK Inhibitor Therapy for CLL: An International Perspective Stephan Stilgenbauer, MD Expert Commentary ClinicalThought™ - Targeted therapies, including BTK inhibitors and combinations incorporating BCL-2 inhibitors, have replaced chemoimmunotherapy as the standard of care for treating CLL.
BTK Inhibitor Therapy for CLL: An International Perspective Stephan Stilgenbauer, MD Expert Commentary ClinicalThought™ - Targeted therapies, including BTK inhibitors and combinations incorporating BCL-2 inhibitors, have replaced chemoimmunotherapy as the standard of care for treating CLL.
lankisterguy
Volunteer
in
CLL Support
1 year ago
Junctional Rhythm
I have had Paroxysmal Afib since 2017, and take Warfarin and Bisoprolol ( now been 5mgs twice daily for a year ). No other drugs. I have been having a lot of unclassified results on my Kardia lately. A few is normal and I always thought it was interference or similar, or me not being still enough. However
I have had Paroxysmal Afib since 2017, and take Warfarin and Bisoprolol ( now been 5mgs twice daily for a year ). No other drugs. I have been having a lot of unclassified results on my Kardia lately. A few is normal and I always thought it was interference or similar, or me not being still enough. However
Tellingfibs
in
Atrial Fibrillation Support
1 year ago
Chemo vs Xofigo
I am seven years from diagnosis (PSA 1,666). Still have my prostate. Firmagon brought PSA to undetectable in five months. After continuous Eligard, Xtandi, and Clinical Trial, back up to 800 PSA. My decision now is this: Chemo or XOFIGO (RA 223). Anyone out there that can help me with their experiences
I am seven years from diagnosis (PSA 1,666). Still have my prostate. Firmagon brought PSA to undetectable in five months. After continuous Eligard, Xtandi, and Clinical Trial, back up to 800 PSA. My decision now is this: Chemo or XOFIGO (RA 223). Anyone out there that can help me with their experiences
fsiefert
in
Advanced Prostate Cancer
1 year ago
Thyroid Blood Test Results
Hi all, I finally managed to get a copy of my thyroid blood test results but there is so little information on there that I’m unsure of what I should do next. I’ve posted before but my situation is that I had a partial thyroidectomy back in July 2022 and I’ve been getting symptoms such as tiredness
Hi all, I finally managed to get a copy of my thyroid blood test results but there is so little information on there that I’m unsure of what I should do next. I’ve posted before but my situation is that I had a partial thyroidectomy back in July 2022 and I’ve been getting symptoms such as tiredness
NiaJayne
in
Thyroid UK
1 year ago
Aspirin75mg / gnawing pain
Hi,Following a long period of very high number of ectopics (now much calmer) my meds are Lipitor40,Bisoprolol 2.5mg and Aspirin75mg. Of late I ve been getting a wave of discomfort emanating in the left chest. Not so much pain just an uncomfortable gnawing sensation. No appts available for a few weeks
Hi,Following a long period of very high number of ectopics (now much calmer) my meds are Lipitor40,Bisoprolol 2.5mg and Aspirin75mg. Of late I ve been getting a wave of discomfort emanating in the left chest. Not so much pain just an uncomfortable gnawing sensation. No appts available for a few weeks
talipia
in
AF Association
1 year ago
New here
Hello everyone I'm a woman in my 60s and was first diagnosed with paroxysmal AFib about a year ago. I've been having an episode about every 4-5 months and was prescribed Flecainide to be taken at the onset of an episode and that seems to stop it within about half an hour, luckily. Unfortunately,
Hello everyone I'm a woman in my 60s and was first diagnosed with paroxysmal AFib about a year ago. I've been having an episode about every 4-5 months and was prescribed Flecainide to be taken at the onset of an episode and that seems to stop it within about half an hour, luckily. Unfortunately,
Hidden
in
Atrial Fibrillation Support
1 year ago
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