Metastatic Castration Resistant prostate cancer

[malihaamjed]

My father underwent turp in jun'12 RP in sep'12 . Gleason score 4+4 tertiary grade 5. PSA kept rising until 12.4 in Nov'14. Bilateral orchiectomy done in Feb'15. PSA kept rising until 116 in Dec'17. PET CT scan revealed multiple bone mets. Started Abiraterone+Prednisone+LH agonist+Bicultamide in December. Pain increased in January. Took 10 days Palliative Radiation Therapy in Feb'18. March'18 PSA 77 which spiked to 232 in next few days. Started Docataxel chemo. After 3 cycles PSA down to 22. After 6 cycles PSA rise to 42. PSMA scan showed reduction in bone mets but 2 new lessons in the axillary lymph node & retroesophageal lymph node. Currently continuing the Docataxel chemo . Has anyone continued Docataxel more than 6 cycles ? When to switch to Cabazitaxel?

[Darryl]

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