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10mg Prednisone daily Energy Rampant- not Sleeping much
26 days on 1st experience w/ Prednisone 5mg 2X/ day. 1st 1 AM w/
Abiraterone
250mg. Excessive Exercising Energy explodes. That’s Ok. 2nd Prednisone 5mg 4-5PM. Excessive Energy increases till bedtime.
26 days on 1st experience w/ Prednisone 5mg 2X/ day. 1st 1 AM w/
Abiraterone
250mg. Excessive Exercising Energy explodes. That’s Ok. 2nd Prednisone 5mg 4-5PM. Excessive Energy increases till bedtime.
depotdoug
in
Advanced Prostate Cancer
4 years ago
Lupron--every three months? or every six months?
Mets to pelvis (fracture of the pelvis), spine and ribs. 10 rounds of external beam radiation on pelvis and base of spine 10/4/2019: received Firmagon and Xgeva Shot (monthly) 11/1/2019: started on
Abiraterone
.
Mets to pelvis (fracture of the pelvis), spine and ribs. 10 rounds of external beam radiation on pelvis and base of spine 10/4/2019: received Firmagon and Xgeva Shot (monthly) 11/1/2019: started on
Abiraterone
.
j5000
in
Advanced Prostate Cancer
5 years ago
2019 Top Stories in Advanced Prostate Cancer: Cabazitaxel vs Abiraterone or Enzalutamide in Metastatic Prostate Cancer
or enzalutamide) in men who had previously been treated with docetaxel or the other androgen signaling–targeted inhibitor (ie,
abiraterone
or enzalutamide).
or enzalutamide) in men who had previously been treated with docetaxel or the other androgen signaling–targeted inhibitor (ie,
abiraterone
or enzalutamide).
Balsam01
in
Advanced Prostate Cancer
5 years ago
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A brief story of using Trintellix (Brintellix) antidepressant
So, if you plan to take an SSRI antidepressant together with
Abiraterone
, be aware of the potential interaction between the drugs. Peace
So, if you plan to take an SSRI antidepressant together with
Abiraterone
, be aware of the potential interaction between the drugs. Peace
dorke
in
Advanced Prostate Cancer
5 years ago
Therapies Targeted to Androgen Receptor SignalingAxis in Prostate Cancer: Progress, Challenges,and Hope - published December 2019
T878A or L702H mutations were found in the plasma of 13% of CRPC patients with
abiraterone
resistance [23]. These muta-tions can be detected in plasma DNA and may help physicians in choosing the appropriate drugs for CRPC patients [24].
T878A or L702H mutations were found in the plasma of 13% of CRPC patients with
abiraterone
resistance [23]. These muta-tions can be detected in plasma DNA and may help physicians in choosing the appropriate drugs for CRPC patients [24].
JLS1
in
Advanced Prostate Cancer
4 years ago
Enzamet
Our oncologist and I had previously discussed potentially adding
abiraterone
shortly after chemotherapy (never did start it though). Now with the Enzamet results, was wondering if I should still push for that, or just wait until/unless PSA starts rising? Thanks, and happy Thanksgiving.
Our oncologist and I had previously discussed potentially adding
abiraterone
shortly after chemotherapy (never did start it though). Now with the Enzamet results, was wondering if I should still push for that, or just wait until/unless PSA starts rising? Thanks, and happy Thanksgiving.
mediocra
in
Advanced Prostate Cancer
5 years ago
BAT failed after 2 years
The JH trials show that BAT re sensitises PCa to enzalutamide (Enza) and
abiraterone
(Abi). My experience is that it does likewise for bicalutamide. When I become resistant to a 2nd generation antiandrogen I will certainly consider reusing BAT. By then we will know more about it.
The JH trials show that BAT re sensitises PCa to enzalutamide (Enza) and
abiraterone
(Abi). My experience is that it does likewise for bicalutamide. When I become resistant to a 2nd generation antiandrogen I will certainly consider reusing BAT. By then we will know more about it.
kaptank
in
Advanced Prostate Cancer
4 years ago
Onvansertib Helps Overcome Resistance to Zytiga in mCRPC Patients, Interim Phase 2 Data Show
An article from Prostate Cancer Today Trovagene’s investigational oral therapy onvansertib may help overcome resistance to Zytiga (
abiraterone
acetate) in men with metastatic castration-resistant prostate cancer (mCRPC), updated Phase 2 data continue to suggest.
An article from Prostate Cancer Today Trovagene’s investigational oral therapy onvansertib may help overcome resistance to Zytiga (
abiraterone
acetate) in men with metastatic castration-resistant prostate cancer (mCRPC), updated Phase 2 data continue to suggest.
Philly13
in
Advanced Prostate Cancer
5 years ago
Veyonda (idronoxil). For enhancing radiation effects and launching abscopal immune response. DARRT Trials and LuPIN Trial
LuPIN-1 trial of Veyonda with Lu-PSMA-617 in mCRPC (Australia) LuPIN-1 is a dose escalation and dose expansion trial of men with mCRPC progressing despite having received docetaxel, cabazitaxel and either
abiraterone
or enzalutamide.
LuPIN-1 trial of Veyonda with Lu-PSMA-617 in mCRPC (Australia) LuPIN-1 is a dose escalation and dose expansion trial of men with mCRPC progressing despite having received docetaxel, cabazitaxel and either
abiraterone
or enzalutamide.
MateoBeach
in
Advanced Prostate Cancer
4 years ago
Testosterone & Docetaxel in CRPC.
KEYWORDS:
abiraterone
; androgen receptor; chemotherapy; enzalutamide; prostate-specific antigen PMID: 31816126 DOI: 10.1002/pros.23938
KEYWORDS:
abiraterone
; androgen receptor; chemotherapy; enzalutamide; prostate-specific antigen PMID: 31816126 DOI: 10.1002/pros.23938
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Survival With Cabazitaxel in Metastatic Castration-Resistant Prostate Cancer in Clinical Practice
All had prior docetaxel, and 82% prior
abiraterone
, enzalutamide or both. Median duration of cabazitaxel treatment was 3.4 months. Median OS from cabazitaxel initiation was 11.9 months [95% CI: 10.1-12.9].
All had prior docetaxel, and 82% prior
abiraterone
, enzalutamide or both. Median duration of cabazitaxel treatment was 3.4 months. Median OS from cabazitaxel initiation was 11.9 months [95% CI: 10.1-12.9].
Balsam01
in
Advanced Prostate Cancer
5 years ago
Best new drugs for castrate-resistant PC?
I'm looking at new drugs; most-mentioned are
abiraterone
, enzalutamide, and apalutamide (while continuing ADT) -- or some combination. I'd much appreciate advice from those who have tried these. Or maybe I should try one of the others mentioned in your Posts? Many thanks, Yeatz
I'm looking at new drugs; most-mentioned are
abiraterone
, enzalutamide, and apalutamide (while continuing ADT) -- or some combination. I'd much appreciate advice from those who have tried these. Or maybe I should try one of the others mentioned in your Posts? Many thanks, Yeatz
yeatz
in
Advanced Prostate Cancer
5 years ago
Change from locally advanced to Advanced PC
I am to start
Abiraterone
in 2 weeks as I am away from home on business. I asked about adjuvant chemo (Docetaxyl?) and was told to start with just the Abi. Does anyone have any advice on my situation? Why would cancer return to seminal vesicles when they would have been targetted during RT?
I am to start
Abiraterone
in 2 weeks as I am away from home on business. I asked about adjuvant chemo (Docetaxyl?) and was told to start with just the Abi. Does anyone have any advice on my situation? Why would cancer return to seminal vesicles when they would have been targetted during RT?
konichiwa12
in
Advanced Prostate Cancer
5 years ago
Started clinical trial
Starting trial next week, with will start me on Apalutamide,
Abiraterone
and prednisone. Trial scheduled to last 24 months, I'll let you know how it goes.
Starting trial next week, with will start me on Apalutamide,
Abiraterone
and prednisone. Trial scheduled to last 24 months, I'll let you know how it goes.
WINGER19
in
Advanced Prostate Cancer
5 years ago
Fluctuating sugar levels on Zytiga and Prednisone
The doctor referred us to a gastro ent. and stopped the
abiraterone
and prednisone for 2 weeks. Post two weeks the lever enzymes were back in control and the doctor advised us to restart 750 mg of zytiga with 5 mg prednisone.
The doctor referred us to a gastro ent. and stopped the
abiraterone
and prednisone for 2 weeks. Post two weeks the lever enzymes were back in control and the doctor advised us to restart 750 mg of zytiga with 5 mg prednisone.
Life5
in
Advanced Prostate Cancer
5 years ago
Antitumor Activity Seen With Keytruda in mCRPC
In the study, 29% of patients had previously undergone two or more chemotherapy regimens, and about 25% were treated with both enzalutamide (Xtandi) and
abiraterone
(Zytiga).
In the study, 29% of patients had previously undergone two or more chemotherapy regimens, and about 25% were treated with both enzalutamide (Xtandi) and
abiraterone
(Zytiga).
snoraste
in
Advanced Prostate Cancer
5 years ago
ASCO GU 2020: Additional Mechanism of Action of PARP Inhibitor Talazoparib Attacks Prostate Cancer Cells, Spares Normal Cells
Participants have received one to two chemotherapy regimens (at least one taxane-based) and progressed on at least one novel hormone therapy (enzalutamide/
abiraterone
acetate).
Participants have received one to two chemotherapy regimens (at least one taxane-based) and progressed on at least one novel hormone therapy (enzalutamide/
abiraterone
acetate).
Balsam01
in
Advanced Prostate Cancer
4 years ago
Criteria for Commencement of Next Line Therapy
Furthermore, it would seem to make more sense to start
abiraterone
therapy, for example, when the PSA is increasing and before it reaches 2 ng/ml. Comments would be appreciated. Cheers, Phil
Furthermore, it would seem to make more sense to start
abiraterone
therapy, for example, when the PSA is increasing and before it reaches 2 ng/ml. Comments would be appreciated. Cheers, Phil
PhilipSZacarias
in
Advanced Prostate Cancer
5 years ago
Indirect Comparisons of Efficacy Between Combination Approaches in Metastatic Hormone-Sensitive Prostate Cancer
In all, seven trials met eligibility criteria using either docetaxel,
abiraterone
acetate, enzalutamide, or apalutamide in combination with ADT.
In all, seven trials met eligibility criteria using either docetaxel,
abiraterone
acetate, enzalutamide, or apalutamide in combination with ADT.
Balsam01
in
Advanced Prostate Cancer
5 years ago
Any experience with PARP inhibitors (Niraparib)?
He has the following options. 1)
Abiraterone
with denosumab and prednisone 2) Join a clinical trial which combines the above along with immunotheraphy (pembrolizumab).
He has the following options. 1)
Abiraterone
with denosumab and prednisone 2) Join a clinical trial which combines the above along with immunotheraphy (pembrolizumab).
ArabianNights
in
Advanced Prostate Cancer
5 years ago
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