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Zytiga + Statins in CRPC
KEYWORDS: SLCO transport;
abiraterone
acetate; duration; prostate cancer; statins PMID: 28762529 DOI: 10.1002/pros.23390
KEYWORDS: SLCO transport;
abiraterone
acetate; duration; prostate cancer; statins PMID: 28762529 DOI: 10.1002/pros.23390
pjoshea13
in
Advanced Prostate Cancer
7 years ago
First line therapy changes
On June 3, 2017, it printed the following trial conclusion: “Among men with locally advanced or metastatic prostate cancer, ADT plus
abiraterone
and prednisolone was associated with significantly higher rates of overall and failure-free survival than ADT alone.
On June 3, 2017, it printed the following trial conclusion: “Among men with locally advanced or metastatic prostate cancer, ADT plus
abiraterone
and prednisolone was associated with significantly higher rates of overall and failure-free survival than ADT alone.
leswell
in
Advanced Prostate Cancer
7 years ago
free Testosterone [fT] & survival.
in 47% of patients in the
abiraterone
arm, while none of the patients continuing regular androgen deprivation exhibited serum testosterone levels below the detection threshold.
in 47% of patients in the
abiraterone
arm, while none of the patients continuing regular androgen deprivation exhibited serum testosterone levels below the detection threshold.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
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Quercetin & AR-V7.
The splice variants AR-V7 and Arv567es have been implicated in the resistance to not only enzalutamide, but also to
abiraterone
and other conventional therapeutics such as taxanes.
The splice variants AR-V7 and Arv567es have been implicated in the resistance to not only enzalutamide, but also to
abiraterone
and other conventional therapeutics such as taxanes.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
abiraterone
hi all a short question i started
abiraterone
+ prednisone in january 17 but after some months or years ? chemio? mha.......... by
hi all a short question i started
abiraterone
+ prednisone in january 17 but after some months or years ? chemio? mha.......... by
Sergio1
in
Advanced Prostate Cancer
7 years ago
LATITUDE - Zytiga & ADT - NEJM Paper
Rates of grade 3 hypertension and hypokalemia were higher in the
abiraterone
group.
Rates of grade 3 hypertension and hypokalemia were higher in the
abiraterone
group.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Help - Zytiga (Abiraterone) with Lupron & anything else you would recommend.
Hi All, I am 56 years old, have been on board with you since April. I was dx in February 2017 with pca, GS 8, PSA 8.8, spreading to left seminal vesicle and two bone mets, one in right pelvis and one in right femur. I have been on Lupron with Casodex (50 mgs daily) and feel a million times better
Hi All, I am 56 years old, have been on board with you since April. I was dx in February 2017 with pca, GS 8, PSA 8.8, spreading to left seminal vesicle and two bone mets, one in right pelvis and one in right femur. I have been on Lupron with Casodex (50 mgs daily) and feel a million times better
Stickingaround1
in
Advanced Prostate Cancer
7 years ago
LATITUDE - Zytiga & ADT
Median OS for the
abiraterone
acetate plus prednisone in combination with ADT arm was not reached, while the median OS for the placebo plus ADT arm was 34.7 months.
Median OS for the
abiraterone
acetate plus prednisone in combination with ADT arm was not reached, while the median OS for the placebo plus ADT arm was 34.7 months.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
abiraterone & nausea
hi i 'm from italy and i'm 66 old I use abiraterome since January, 4 pills a day, and unlucky I suffer from a slight nausea. Can anyone give me quache advice? Thanks Sergio
hi i 'm from italy and i'm 66 old I use abiraterome since January, 4 pills a day, and unlucky I suffer from a slight nausea. Can anyone give me quache advice? Thanks Sergio
Sergio1
in
Advanced Prostate Cancer
7 years ago
CRPC & Prednisolone or Dexamethasone. Neutrophil to Lymphocyte Ratio [NLR].
A 2015 paper [2] details a Phase II study "among chemotherapy naïve CRPC patients who had not received prior
abiraterone
or enzalutamide therapy."
A 2015 paper [2] details a Phase II study "among chemotherapy naïve CRPC patients who had not received prior
abiraterone
or enzalutamide therapy."
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Taking Abiraterone with food
I have been taking for the last six months or so, 3
abiraterone
with my evening meal and then one at bed time. This certainly dropped my PSA initially, but now it is rising again. Has anyone any experience of taking one with each meal throughout the day?
I have been taking for the last six months or so, 3
abiraterone
with my evening meal and then one at bed time. This certainly dropped my PSA initially, but now it is rising again. Has anyone any experience of taking one with each meal throughout the day?
NiallMcC
in
Advanced Prostate Cancer
7 years ago
STAMPEDE - Zytiga at ADT initiation.
Abiraterone
can clearly help many more prostate cancer patients than was first thought.
Abiraterone
can clearly help many more prostate cancer patients than was first thought.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Abiraterone - "Prostate cancer trial stuns researchers: 'It's a once in a career feeling' "
ID=60498&sortMenu=101001 https://www.theguardian.com/society/2017/jun/03/prostate-cancer-therapy-study-
abiraterone
“
Abiraterone
not only prolonged life, but also lowered the chance of relapse by 70% and reduced the chance of serious bone complications by 50%,” James said.
ID=60498&sortMenu=101001 https://www.theguardian.com/society/2017/jun/03/prostate-cancer-therapy-study-
abiraterone
“
Abiraterone
not only prolonged life, but also lowered the chance of relapse by 70% and reduced the chance of serious bone complications by 50%,” James said.
JLS1
in
Advanced Prostate Cancer
7 years ago
STAMPEDE - Zytiga at ADT initiation. NEJM Paper.
Abiraterone
(1000 mg) with prednisolone (5 mg) was given once daily.
Abiraterone
(1000 mg) with prednisolone (5 mg) was given once daily.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Early Abiraterone plus ADT gives survival benefit, but may not be accessible to Aussie's for a while.
As you may be aware, there has been a lot on the internet recently about adding
Abiraterone
to ADT early before becoming castrate resistant and a significant survival benefit.
As you may be aware, there has been a lot on the internet recently about adding
Abiraterone
to ADT early before becoming castrate resistant and a significant survival benefit.
paulofaus
in
Advanced Prostate Cancer
7 years ago
Favorable Casodex withdrawal
So it looks like I'm buying time before I have to start taking Zytiga (
abiraterone
acetate). My point is, when things start looking bleak, good things can and do happen.
So it looks like I'm buying time before I have to start taking Zytiga (
abiraterone
acetate). My point is, when things start looking bleak, good things can and do happen.
Hidden
in
Advanced Prostate Cancer
7 years ago
Resveratrol & ARV7
Since it lacks the ligand binding domain but retains the intact DNA binding domain, ARV7 is constitutively active, which makes ARV7-positive prostate cancer responsive to neither
abiraterone
nor enzalutamide.
Since it lacks the ligand binding domain but retains the intact DNA binding domain, ARV7 is constitutively active, which makes ARV7-positive prostate cancer responsive to neither
abiraterone
nor enzalutamide.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Melatonin & AR-V7
Given that constitutively active androgen receptor splice variants, in particular AR-V7, have been shown to confer resistance to
abiraterone
or enzalutamide, and that activation of NF-κB and reactivation of AR signaling are involved in prostate cancer progression and CRPC development, it would be of
Given that constitutively active androgen receptor splice variants, in particular AR-V7, have been shown to confer resistance to
abiraterone
or enzalutamide, and that activation of NF-κB and reactivation of AR signaling are involved in prostate cancer progression and CRPC development, it would be of
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Advanced Metastatic Prostate Cancer
I asked this question to my doctor and he is waiting for results on a study of Zytiga (
abiraterone
acetate) and that we may want to start with that before my two years are up with Lupron. Has anyone taken or are taking Zytiga? What is your experience with the drug?
I asked this question to my doctor and he is waiting for results on a study of Zytiga (
abiraterone
acetate) and that we may want to start with that before my two years are up with Lupron. Has anyone taken or are taking Zytiga? What is your experience with the drug?
grahaminator63
in
Advanced Prostate Cancer
7 years ago
Medicines to b avoided with Ibnutrib
http://www.mayoclinic.org/drugs-supplements/ibrutinib-oral-route/before-using/drg-20084873 Some other medications that shouldn’t be consumed while taking this drug are: ·
Abiraterone
· Amprenavir · Aprepitant · Carbamazepine · Ciprofloxacin · Clarithromycin
http://www.mayoclinic.org/drugs-supplements/ibrutinib-oral-route/before-using/drg-20084873 Some other medications that shouldn’t be consumed while taking this drug are: ·
Abiraterone
· Amprenavir · Aprepitant · Carbamazepine · Ciprofloxacin · Clarithromycin
Anilbhard
in
CLL Support
7 years ago
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