Abiraterone acetate (1) 250mg tab with food same as 4 without food?

[depotdoug]

Today late breaking news:::::::

My ONC pharmacies pharmacist told me

(1) 250mg ABIRATERONE Acetate tab with food(meal) is as effective as (4) 250mg ingested on empty stomach.

Where is this Clinical Study found.??

Help me fellow pharmacology experts.

[tango65]

ncbi.nlm.nih.gov/pmc/articl...

[LearnAll]

YESSSSSSSS ! I have been taking 250 mg with a cup of full fat yogurt for last 4 months,. doing welllll

[Tall_Allen]

I just answered this - don't you guys ever use a search bar first? Here's some info on food with Zytiga. Absorption varies greatly between patients and these were very small studies, so there is no guarantee it will be equivalent to 1000 mg dosing

With low fat breakfast: ascopubs.org/doi/10.1200/JC...

With high fat breakfast: meetinglibrary.asco.org/rec...

Absorption higher with high fat meal: accp1.onlinelibrary.wiley.c...

[depotdoug in reply to Tall_Allen]

Thanks. I’m a new student to this arena Tall_Allen. Please help me understand and your really are.

One I’m trying to avoid cardiac arrest again, guess that’s why I’ve got my 2nd ICD/pacemaker implanted.

Plus my Med ONC ok’d (1) 250mg Zytiga (abiraterone) tab for now.

Next visit my Dr A. Is Feb 4th ~ 7 weeks on Abiraterone 250 w/o food.

Yes, my Cardiologist and Electrophysiologist are aware.

Final point... Med ONC Dr A. can always go up in dose on me. Not if I’m dead. Ooops I’ve got an implanted Cardioversion device and pacing device inside my chest.

I surely appreciate your ads an Ed knowledge of these treatment metgods. What a great asset you are, Tall_Allen

[depotdoug in reply to Tall_Allen]

Those articles on AA dosage vs food absorption are extremely knowledgeable to read although a bit old. I do appreciate you pointing them to my and all of us.

[jfoesq in reply to depotdoug]

FYI

My doc at MSKCC is aware of them but wants me to stick with the 4 pills without food.

[depotdoug in reply to jfoesq]

Sounds good. I’m willing to up mine Feb 4th at my Med ONC next visit if I’d if if my Cardiac Rhythm and Liver labs behave nicely 🙁

[MateoBeach]

The recent discussion on this topic was good. 250 mg with food dosing should be appropriate for many to try. But reviewing the pharmacodynamics , not just of the absorption (pharmacokinetics) but of the binding at the target enzyme CYP17a1 and the "completeness" of competitive blockade of its multiple sites of action. Then coupled with partial agonist activity at AR receptors, etc. (See concise summary

en.wikipedia.org/wiki/Abira...

I took note of one participant here that after progressing on 250 mg dosing, increased to 1,000 mg and again observed a positive response. Must remain vigilant and flexible!

[depotdoug in reply to MateoBeach]

Wow, so much to absorb so to speak, but so little time. MateoBeach where do you get learn all of these pharmacy kinetics, combinations, results? I'll read the wiki/Abiraterone link next.

Do the medical oncologist(s) stay up to speed on all of these "absorption" studies?

Depotdoug

[AlanLawrenson]

You ask do MO keep up to date. My brother is under a Professor of MO for his Stage 4 and not doing very well (hospitalized). As an author of three books on PCa, I gave my brother a list of immunotherapies/chemo that should be considered. MO reviewed my list and selected Xtandi. Some of his comments were very revealing regarding his (lack of ) knowledge level right now.

However, when you have 14 hospital patients to see in less than 90 minutes, it's not surprising that he isn't up-to-date!!

[AlanLawrenson]

A follow-up. What I meant to add. It is essential that your MO specialise in PCa. A generalist treating all Ca types can't possibly be up-to-date. I suppose that's why their professional body issues Guidelines of Approved Therapies.

[depotdoug in reply to AlanLawrenson]

My Med Onc specialty is in clinical interests include medical oncology, with a specific focus on urologic oncology and the treatment of prostate, testicular, bladder and kidney cancers.

That's all that I know. But I think he is an assistant professor advisor on the same subjects.