A brief story of using Trintellix (Brintellix) antidepressant

[dorke]

Hello brothers in arms.

I've been fighting this disease for about 18 months now.

Since my diagnosis my life changed a lot as expected.

I'm not sleeping as I used to, my life does not have any colors, and find it hard to concentrate.

My GP thought I might be going thru depression so he prescribed me with 15mg Trintellix which is an SSRI antidepressant.

As usual with SSRIs I started gradually .Even before I got the the max dose, I began to experience lots of difficulties urinating.

I started experiencing urgency, felt I couldn't void completely, and run to the toilet many times at night.

At that moment I didnt think it might be related to Trintellix but I started to check on it.

It turns out Trintellix ,as many other antidepressants,is metabolized by enzyme CYP2D6. I'm currently taking Abiraterone which is a strong inhibitor of CYP2D6.

The result is that I suffered hard from Trintellix (rare...)side effects.

Obviously I had to stop Trintellix.

So, if you plan to take an SSRI antidepressant together with Abiraterone, be aware of the potential interaction between the drugs.

Peace

[Hex40]

I take Wellbutrin every morning and a little lorazepam at night to help me sleep. All things considered it works pretty well for me. If you want to go that route may want to consider seeing a psychiatrist for the proper diagnosis and meds. It saved me from the spiral I was in.

[dorke in reply to Hex40]

Thank you Hex

What dose of Wellbutrin are you taking?

I read some people may experience irritability with Wellbutrin

[Hex40 in reply to dorke]

I started with 150 mg for 2 weeks then went to 300 mg. For sleeping I generally fall asleep on my own but wake up after a couple hours. I then take 2 .5 lorazepam that lets me sleep for about 4 or 5 hours. If necessary I take an additional .5 around 5 am that gives me another 2 or 3 hours. I initially started out taking mirtazapine for anxiety but after several months it was causing horrible restless leg at night so that was scrapped. Regarding irritability it does happen on a very rare occasion. Sometimes I get a little short with my wife but we both realize it’s the meds

[dorke in reply to Hex40]

Thanks again.

I'll discuss it with my doc.

BTW, are you 64 ? 😉

[Hex40 in reply to dorke]

65 in January. I started Medicare today!

[j-o-h-n in reply to Hex40]

"Sometimes I get a little short with my wife but we both realize it’s the meds".

Thanks for the tip.....

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 12/02/2019 8:15 PM EST

[LearnAll]

NOT ALL SSRI antidepressants are metabolized thru CYP2D6 pathway.

The ones which are not metabolized thru CYP2D6 are (1) Sertraline (Zoloft), (2) Citalopram (celexa) and Escitalopram (Lexapro)

[dorke]

Thank YOU for all the info you share with this forum

[marnieg46]

My husband has battled quite a bit with depression since being diagnosed and having a rocky road since. He notices a real benefit and we've both seen a difference in how he copes by taking 50mg of Zoloft daily. He does not seem to have experienced any side effects that could be attributed to Zoloft.

[j-o-h-n]

I say, piss on Trintellix (Brintellix) !!!.....

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 12/02/2019 8:18 PM EST

[dorke in reply to j-o-h-n]

I would...if I could