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GA 68 PSMA PET SCAN RESULTS
Tall Allen, I read the SPPORT Trial you sent me and if I understand correctly it looks like the next line of treatment should be RT to the pelvic bed and the lymph nodes, possibly administering Apalutamide vs.
abiraterone
or enzalutamide.
Tall Allen, I read the SPPORT Trial you sent me and if I understand correctly it looks like the next line of treatment should be RT to the pelvic bed and the lymph nodes, possibly administering Apalutamide vs.
abiraterone
or enzalutamide.
GMan-62
in
Advanced Prostate Cancer
2 years ago
Switch of corticosteroids from prednisone to dexamethasone
The
abiraterone
is fighting a great rearguard action, but slowly failing. I’d like to keep it efficacious as long as possible.
The
abiraterone
is fighting a great rearguard action, but slowly failing. I’d like to keep it efficacious as long as possible.
Tonyliv
in
Advanced Prostate Cancer
2 years ago
No More Orgovyx, Continuing with Abiraterone and Prednisone
My MO and I have just decided to try the methodology reported in the study titled: "Suppression of testosterone production using
abiraterone
acetate (AA) with or without androgen deprivation therapy (ADT) in metastatic castration resistant prostate cancer (mCRPC)".
My MO and I have just decided to try the methodology reported in the study titled: "Suppression of testosterone production using
abiraterone
acetate (AA) with or without androgen deprivation therapy (ADT) in metastatic castration resistant prostate cancer (mCRPC)".
rmarkley
in
Advanced Prostate Cancer
2 years ago
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Benefit of "triplet therapy" confirmed with enzalutamide too
https://www.urotoday.com/conference-highlights/asco-2022/asco-2022-prostate-cancer/137646-asco-2022-updated-overall-survival-outcomes-in-enzamet-anzup-1304-an-international-cooperative-group-trial-of-enzalutamide-in-metastatic-hormone-sensitive-prostate-cancer-mhspc.html Enzalutamide (Xtandi) joins
abiraterone
https://www.urotoday.com/conference-highlights/asco-2022/asco-2022-prostate-cancer/137646-asco-2022-updated-overall-survival-outcomes-in-enzamet-anzup-1304-an-international-cooperative-group-trial-of-enzalutamide-in-metastatic-hormone-sensitive-prostate-cancer-mhspc.html Enzalutamide (Xtandi) joins
abiraterone
Tall_Allen
in
Advanced Prostate Cancer
2 years ago
Help: Metastasized Castration Resistant Prostate Cancer!
Later I was switched to Zytiga (
abiraterone
acetate) with an injection of lupron every three months.Then I was put on Xtandi with lupron once per month. The Xtandi didn’t lower my PSA, but seemed to have more side effects than the others.
Later I was switched to Zytiga (
abiraterone
acetate) with an injection of lupron every three months.Then I was put on Xtandi with lupron once per month. The Xtandi didn’t lower my PSA, but seemed to have more side effects than the others.
Yin-Yin
in
Advanced Prostate Cancer
2 years ago
Probiotics
Are there any pros or cons to probiotics while on Lupron,
Abiraterone
, and prednisone? Jim has never in his life gotten staph infections, and he is now fighting his second one on his skin within 4 months. Thinking he doesn't have enough friendly bacteria in his system. Thank you
Are there any pros or cons to probiotics while on Lupron,
Abiraterone
, and prednisone? Jim has never in his life gotten staph infections, and he is now fighting his second one on his skin within 4 months. Thinking he doesn't have enough friendly bacteria in his system. Thank you
JWPMP
in
Advanced Prostate Cancer
2 years ago
Looking for a trainer/coach that understands low-T/ADT training
I'm 4 years in on the standard triple blockade (
Abiraterone
/ Orgovyx / Dutasteride) and things are going very well. PSA is stable at < 0.01. And I just rode a century ride this past weekend. (woot!)
I'm 4 years in on the standard triple blockade (
Abiraterone
/ Orgovyx / Dutasteride) and things are going very well. PSA is stable at < 0.01. And I just rode a century ride this past weekend. (woot!)
catbus
in
Advanced Prostate Cancer
2 years ago
Abiraterone-Related Hypokalemia
" [2] "
A Case of
-Related Hypokalemia Leading to Torsades de Pointes and Cardiac Arrest" [1] "By inhibiting CYP17,
abiraterone
can induce a state of mineralocorticoid excess, which is associated with profound hypokalemia.
" [2] "
A Case of
-Related Hypokalemia Leading to Torsades de Pointes and Cardiac Arrest" [1] "By inhibiting CYP17,
abiraterone
can induce a state of mineralocorticoid excess, which is associated with profound hypokalemia.
pjoshea13
in
Advanced Prostate Cancer
2 years ago
Duration of ADT
ESMO 2021:
Abiraterone
Acetate Plus Prednisolone With or Without Enzalutamide Added to ADT Compared to ADT Alone for Men With High-Risk Non-Metastatic Prostate Cancer: Combined Analysis From Two Comparisons in the STAMPEDE Platform
ESMO 2021:
Abiraterone
Acetate Plus Prednisolone With or Without Enzalutamide Added to ADT Compared to ADT Alone for Men With High-Risk Non-Metastatic Prostate Cancer: Combined Analysis From Two Comparisons in the STAMPEDE Platform
hg115pb
in
Advanced Prostate Cancer
2 years ago
Rezvilutamide: new anti-androgen is better than Casodex added to ADT for newly diagnosed high-met HSPC. But is field too crowded?
With Zytiga (
abiraterone
), Xtandi (enzalutamide), and Erleada (apalutamide) and docetaxel already approved for this purpose, I don't know whether Jiangsu Hengrui will be able to make significant inroads into the market, unless they are able to compete on price.
With Zytiga (
abiraterone
), Xtandi (enzalutamide), and Erleada (apalutamide) and docetaxel already approved for this purpose, I don't know whether Jiangsu Hengrui will be able to make significant inroads into the market, unless they are able to compete on price.
Tall_Allen
in
Advanced Prostate Cancer
2 years ago
Arrhythmia and Zytiga
I have been on
abiraterone
for about a year and a half along with Lupron. I’m currently seeing a cardiologist because the last two weeks I’ve developed heart palpitations/arrhythmia.
I have been on
abiraterone
for about a year and a half along with Lupron. I’m currently seeing a cardiologist because the last two weeks I’ve developed heart palpitations/arrhythmia.
bean1008
in
Advanced Prostate Cancer
2 years ago
My Turn to Ask a Question
In my case, this would mean coming off Xtandi and going onto Zytiga (
abiraterone
). Health Canada has not approved the use of Lutetium 177-PNT2002 for metastatic prostate cancer but has allowed its use in this study.
In my case, this would mean coming off Xtandi and going onto Zytiga (
abiraterone
). Health Canada has not approved the use of Lutetium 177-PNT2002 for metastatic prostate cancer but has allowed its use in this study.
RyderLake2
in
Advanced Prostate Cancer
2 years ago
Please weigh in on Treatment Plan
Aggarwal's Androgen Annihilation trial for 1 year (Degarelix +
Abiraterone
+ Apalutamide + Prednison). He stayed non-detectable for 1 year post trial and now, but PSA has been on the rise. The last PSMA scan found 1 small avid lesion on his pelvic bone for which he had SBRT.
Aggarwal's Androgen Annihilation trial for 1 year (Degarelix +
Abiraterone
+ Apalutamide + Prednison). He stayed non-detectable for 1 year post trial and now, but PSA has been on the rise. The last PSMA scan found 1 small avid lesion on his pelvic bone for which he had SBRT.
Jlgjdf
in
Advanced Prostate Cancer
2 years ago
Enzalutamide - less is more?
Low-dose patients had less prior
abiraterone
or chemotherapy (28.1% vs. 65.8%, P < .001); more testosterone assessment (65.6% vs. 40.5%, P = .016); poorer ECOG performance status (48.3% score ≥2 vs. 26.6%; P = .040), more comorbidities (75.9% vs. 46.3%; P = .010)) including increased cardiovascular disease
Low-dose patients had less prior
abiraterone
or chemotherapy (28.1% vs. 65.8%, P < .001); more testosterone assessment (65.6% vs. 40.5%, P = .016); poorer ECOG performance status (48.3% score ≥2 vs. 26.6%; P = .040), more comorbidities (75.9% vs. 46.3%; P = .010)) including increased cardiovascular disease
pjoshea13
in
Advanced Prostate Cancer
2 years ago
250 mg dose of Abiraterone with low fat meal
For those of you on this protocol has anyone described the size of the meal necessary to make this work effectively? I recently switched from four pills to one because of high liver enzymes. I used to take the 4 pills around 1 AM when I got up to pee. Having a little trouble remembering to take a single
For those of you on this protocol has anyone described the size of the meal necessary to make this work effectively? I recently switched from four pills to one because of high liver enzymes. I used to take the 4 pills around 1 AM when I got up to pee. Having a little trouble remembering to take a single
Scout4answers
in
Advanced Prostate Cancer
2 years ago
Pluvicto Availability in the US
My first PSMA PET confirms that my adenocarcinoma has reactivated and is no longer responsive to
Abiraterone
/pred and Lupron. My oncologist feels I would be a good candidate for Lutetium 177 PSMA therapy however there is no supply in Colorado except for a clinical trial at the University.
My first PSMA PET confirms that my adenocarcinoma has reactivated and is no longer responsive to
Abiraterone
/pred and Lupron. My oncologist feels I would be a good candidate for Lutetium 177 PSMA therapy however there is no supply in Colorado except for a clinical trial at the University.
DenDoc
in
Advanced Prostate Cancer
2 years ago
End of Treatment Options? Oncologist says Make Yourself Comfortable Suggestions
His wife inquired whether or not he could go back on
abiraterone
however given that he had both radiological and PSA progression on
abiraterone
this would no longer be funded and unlikely to be of any clinical benefit.
His wife inquired whether or not he could go back on
abiraterone
however given that he had both radiological and PSA progression on
abiraterone
this would no longer be funded and unlikely to be of any clinical benefit.
Willy9173
in
Advanced Prostate Cancer
2 years ago
Swollen feet with some intermittently mild increase in neuropathy.
Eligard and
Abiraterone
with prednisone continue to be my current meds while in the HS/CS status. Hoping this is primarily due to pushing myself activity wise, more than a side effect from meds; and wondering if maybe compression hosiery might be helpful for some brief length of time.
Eligard and
Abiraterone
with prednisone continue to be my current meds while in the HS/CS status. Hoping this is primarily due to pushing myself activity wise, more than a side effect from meds; and wondering if maybe compression hosiery might be helpful for some brief length of time.
Shams_Vjean
in
Advanced Prostate Cancer
2 years ago
Question about weight lifting while on anti testosterone therapy.
I was placed of
abiraterone
and ADT 6 months ago. I am an avid exerciser so I have not experienced any fatigue but I think I was noticing mild weakness. I decided to start weight lifting. My question is: Do I expect to get stronger or just slow the deterioration.
I was placed of
abiraterone
and ADT 6 months ago. I am an avid exerciser so I have not experienced any fatigue but I think I was noticing mild weakness. I decided to start weight lifting. My question is: Do I expect to get stronger or just slow the deterioration.
Grandpa4
in
Advanced Prostate Cancer
2 years ago
Olaparib Tolerability and the Management of Common Adverse Events in Patients With mCRPC
METHODS Patients were randomized (2:1) to olaparib tablets (300 mg bid) or control (enzalutamide or
abiraterone
) until disease progression or unacceptable toxicity. Safety was assessed through AE reporting and laboratory assessments.
METHODS Patients were randomized (2:1) to olaparib tablets (300 mg bid) or control (enzalutamide or
abiraterone
) until disease progression or unacceptable toxicity. Safety was assessed through AE reporting and laboratory assessments.
Balsam01
in
Advanced Prostate Cancer
2 years ago
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