Magnitude trial: niraparib + abiraterone

[kaptank]

An early report from the magnitude trial. Looks pretty good. Janssen is hoping this combination will become SOC for those with HRR mutations. I am in another arm of the trial where we all get the combination. I am BRCA2. Its about 14 months now. Scans show no growth. PSA sitting 1-2 from an initial 25.

practiceupdate.com/C/132355...

[davebliz]

Thanks for posting. I was in the blinded trial for 8 months when new tumors appeared and the trial ended. I’m pretty sure I was on the placebo arm. I’m BRCA2, going to see if I can get Niraparib because I was in the trail.

[MateoBeach in reply to davebliz]

Yes, see if you can get it. See also other discussion today on crossovers in trials.

[davebliz]

What side effects did you get from the Niraparib?

[kaptank in reply to davebliz]

SEs: very bad constipation (used Epsom salts) and dry mouth/ salivary glands (there are several practical means to keep them pumping). The rest were the symptoms of abi + ADT

[HopingForTheBest1]

Also BRCA2 and was treated with Olaparib prior to being FDA approved. It kept my PSA undetectable for almost 2 years before it ran it's course. I was told that going on to another PARP would not be effective for me as they work similarly. I hope that we will find out that a combo PARP therapy will be an effective option for those of us who already were on a PARP previously.

[davebliz in reply to HopingForTheBest1]

Thanks for the info. What did you go on after the PARP?

[HopingForTheBest1 in reply to davebliz]

Participated in several clinical trials which unfortunately were not effective. Started chemo 2 weeks ago using combo Cabazitaxl and Carboplatin. Hoping it will help.

I have been trying to find the next viable therapy after PARP failure. But have found nothing so far, other than this combo chemo treatment.

[MateoBeach]

Happy that it seems to be working well for you.👍🙏