TRUQAP

[Yikes123]

I posted 2 weeks ag about this newly approved FDA drug for MBC. Seems not many folks have heard about it.

I started a month ago with minimal side effects.

Anyone else on this?

[Cherry38]

Could I ask what the drug is called? Happy New year Yikes123 hope 2024 is a wonderful year for you 🙏🎊🍾🥂🎊

[Yikes123 in reply to Cherry38]

Truqap is the marketing name for capiverstib. It’s for after your first line fails. I was on Ibrance for five years. I take this oral medicine 4 days on 3 days off, coupled with a monthly fulvestrant injection.

[Cherry38 in reply to Yikes123]

I have heard of this drug, awesome it's been approved. Not sure in Australia as yet, our FDA is a bit behind and our PBS system. But I will check it out.I was firstly diagnosed er+pr+her 2 negative with pik3ca mutation, unfortunately after 3 lines of treatment in 14 months I kept getting progression. I started on Riboclicib and Lextrozle. Then I went on two clinical trials. First one I got arm A so I was put on Capecitabine, I had an oophorectomy while on this.

Then I got more progression in my liver so I then travelled a 4 hour trip to get on another trial and got Arm A again which was piqray and fulvestrant.

It helped a little for the pik3ca but I got more spots in my ribs.

So I had another biopsy from my hip bone and I found out my cancer has changed and I am triple negative so at the moment I am on doxorubicin pegylated liposomal every 28 days.

I have had a lot of radiotherapy as well in the 15 months now since diagnosis.

I respond well to radiotherapy shame it can't be done all over at once.

So now my biopsy has been sent to Sydney for further research to see what other trials there are for TNBC with pik3ca.

It's amazing how many drugs that are being researched. This sounds a good drug with less toxicity. I think if I was still had my first diagnoses it would of worked for me. I am so glad there is another drug passed for the pik3ca and other mutations.

I hope it works really well for you, that's awesome your first line worked for so long. I should really still be on Riboclicib if it worked for me, other ladies I know have been on it for at least 3 years so far which is wonderful.

My cancer seems to be very naughty and aggressive. I am glad I got that second opinion and biopsy. All I pray for this year is stability and no more progression as my teenagers need me as I do them.

I hope you have a wonderful New years day. Keep strong 💪 🩷

[Yikes123 in reply to Cherry38]

fda.gov/drugs/resources-inf...

[TammyCross]

I have read about it. Sounds good -- especially since you aren't having bad side effects -- but effective only for people with certain mutations. (I have a mutation with no known treatment. I wish they would get on it. There are some possible pathways but they are far from human testing.)

[Bonnie1942]

Is this the drug you have to take a test to see if you can take it.?

[Yikes123 in reply to Bonnie1942]

Hello. Please see my most recent update below which I hope answers your question.

[Fiercefighter13]

This is my next stop after Xeloda stops working. Luckily Xeloda has been my home run drug since Ibrance, Verzenio, Letrozole, Anastrozole and Fulvestrant only had short limited success for me. My doctor is very excited about Capiverstib as it is getting stellar results. For now though, I’m towing the line with Xeloda hoping it lasts another year or two.

[Mumberly]

it’s great to hear about this new medication! And that there’s so much research into this predictably unpredictable disease.

I’ve been on ibrance and letro for a little over a year now, after initial IV chemo treatments and I’m excited to hear there are so many possibilities down the line.

All the best with your new meds.

Kim

[mariootsi]

Keep us updated. Never heard of this drug.

[Yikes123]

Today I had my first monthly blood work since I started TruQap. My TM dropped 94 points. My oncologist was pleased as she did not anticipate this quick a drop.

DX MBC in 2018 after Stage 2 in 2004 and Stage 3 in 2014. After 5 years on Ibrance, switched to Fulvestrant in 2023. Was bone only until recently. Now small cm in liver too. Now using both Fulvestrant and TruQap.

The two most likely side effects of TruQap are a rash or diarrhea. I've not experienced either. As a precaution against rashes, I took Allegra before the dosage began. Since I've not experienced the rash, my doctor agrees I need not continue it.

I have very slight nausea which I manage with meds from my doctor.

Below is an excerpt about this new drug from the FDA website:

On November 16, 2023, the Food and Drug Administration approved capivasertib (Truqap, AstraZeneca Pharmaceuticals) with fulvestrant for adult patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative locally advanced or metastatic breast cancer with one or more PIK3CA/AKT1/PTEN-alterations, as detected by an FDA-approved test, following progression on at least one endocrine-based regimen in the metastatic setting or recurrence on or within 12 months of completing adjuvant therapy.

FDA also approved the FoundationOne®CDx assay as a companion diagnostic device to identify patients with breast cancer for treatment with capivasertib with fulvestrant.

[awesome4ever in reply to Yikes123]

That's wonderful news! I'm in Canada and it's not approved here yet by Health Canada. However I have a friend that lives in the US that started on this drug exactly one month ago. It is given with Fulvestrant as you know. I actually received an email from her yesterday and her first month bloodwork is very similar to yours. Her TM dropped 90+ points and like you she has slight nausea but hasn't as of yet experienced either the rash or the diarrhea. You are only 2 people but it sounds promising and I hope it works for you for a long time. Thanks for sharing.

[Maraki]

do you have to take truqap with Fulvestrant?

[Yikes123 in reply to Maraki]

I do not know if a patient has to take both of them. I myself take both.