Anyone with bone marrow involvement?

[Olha]

I have stable bone metastases (since July 19) on Letrozole and 75mg IBrance (3 weeks on 2 off due to low neutrophils) with Primary in 2010. My haemoglobin is dropping quite quickly last 2 months, will have to have a transfusion next week, and now neutrophils and platelets also dropping despite holding IBrance last 6 weeks to see if it was the drugs affects.

My liver AST also rising and LDH and ferritin but all other blood markers normal and liver is fine. Cancer was in my marrow back in 2019 so feel it must be some activity in marrow, bone scan 3 weeks ago still stable. My oncologist not interested in LDH or ferritin but now looking at AST.

Any thoughts or experience gratefully received!

My best wishes, Kate x

[Iwasborntodothis]

My right hip and femur joint was 100% cancer through the marrow when I had a scan and MRI in August 2020. I had five small doses of radiation and it has cleared up along with the pain which really hadn't been that bad.

[Olha in reply to Iwasborntodothis]

Thank you for your reply. Has the cancer in the marrow affected your blood counts - the haemoglobin for example?

[Iwasborntodothis in reply to Olha]

My blood counts are all normal which stuns my team at the cancer center ...all but my CA15 which is ridiculously high. I am on Xeloda now and hoping it will knock those down.

[SoCalLady in reply to Iwasborntodothis]

May I ask what your CA15 counts are? Also, do you do CA 27-29, and if so, what are those numbers?

[Iwasborntodothis in reply to SoCalLady]

I don't post them because I don't want to freak anyone out. My CA-15 started at 636 in 2019 and was over 8000 (yes thousand) last visit - hoping Xeloda will change that.My other similar test is CEA and it started at 3.4 and rose to 9.9 last visit.

[howsthis]

i have similar mets in my bones and take letrozole and ibrance 125 mg. my numbers have been good since i started in 2017, with an occasional dip in the white blood count. when that happens i take a week off the ibrance to let the wbc build back up. after full bone scans in december, my mets remain stable and i can live with the side effects of the ibrance, so here i'll stay for now. 😀

[Bexly in reply to howsthis]

My story is same as yours.

[Iwasborntodothis]

yep Doc asked if I was trying to go for a record

[SoCalLady in reply to Iwasborntodothis]

I don't want to beat your record, but I'm close behind @ 7769. Onc has no clue why. Will be doing a liver bio to try to get more insight. However, I have progression in both bones and liver so that could be it.