CLINICAL TRIAL w/ ALISERTIB

[intlstar1]

After 4 cycles of Ibrance along w/ Fulvestrant injections another tumor appeared in my left breast that continues to grow. The 1st tumor that I discovered initially in that breast went away after 16 rounds of intravenous chemo in 2017. A mastectomy was not done as my cancer had already metastasized and I was considered stage IV from the onset. My Oncoligist highly recommends that I participate in a clinical trial starting next Tuesday where I will either be in Group A taking Alisertib on days 1-3, 8-10, 15-17 w/ Fulvestrant or in Group B taking Alisertib w/out Fulvestrant.

Is anyone else in this study? If so, any luck? Side-effects? I'm debating whether I should even get involved as I feel this is their last resort. I'm not in any pain, never have been so I'm wondering if I should just let nature run it's course and stop all treatment. Not to mention my medical insurance is $934/mo and I'm not working. Friends & family members have been helping pay it but enough is enough!! I might be better off just going the holistic route if this clinical trial is my last resort.

[klhowe]

I had progression of my liver tumors for the first 4 months on Ibrance and Femara. It took 8 months before the tumors showed measureable shrinkage on the scans. Maybe you need to give it more time.

Also, have you applied for SSDI? I applied and was approved in 3 weeks. I will get full retirement benefit now at 50, and benefits for my kids who are under 18. In 2 years I can get Medicare if I want it.

Hey, every little bit helps.

[intlstar1 in reply to klhowe]

Thank u for your kind reply. I did in-fact apply for Federal disability. Waiting to hear... Yes, indeed; every bit counts!!

[SoCalLady]

Hi intistar1. I think you should definitely follow your onc's highly recommended advice to go on this clinical trial. I don't think this is being considered as your last resort at all. I think your onc is being sensitive to your present monetary situation and thinks this will be helpful to your particular MBC. The clinical trial will pay for your drugs, which could potentially be $15,000+/month. The side effects will probably be similar to Ibrance or any of these other inhibitors that so many of us are taking. That also doesn't mean you're going to even experience any of these side effects, or if you do experience one or two, that it won't be tolerable. You're young, you're not in pain......Go Girl...do the trial like a warrior!

[daniellebrooks13]

Hello Intlstar1,

I strongly agree with SoCalLady,

Yes, do the clinical trial where your drugs will get paid for. It's not a last option, If it doesn't work, I am sure there are other cocktails that you could take.

And by then you'll be getting disability which will help a little. Keep the faith!

[Godbeforme]

Goodness knows, I wish my memory was better when I quote others but here goes anyway! That MBC conference they just held last month, a doctor said they were releasing to trial basis the natural killer cell treatment, and that they had the nk cells where they can now make them in the lab and they will work on anyone, without having to harvest your own cells, etc. This sounded so promising to me; so much promise out there! God bless you!

[Godbeforme]

My intentions were good! I had looked up the drug name alisertib because I had never heard of it and found this. Although this trial was for lymphoma, I still thought you might want to read what google found. God bless you. Lord Jesus, please do not let me offend anyone unawares!

DescriptionAlisertib is an orally available selective aurora A kinase inhibitor developed by Takeda. It was investigated as a treatment for relapsed or refractory peripheral T-cell lymphoma. Development was abandoned in 2015 due to poor clinical trial results. Wikipedia

ChemSpider ID: 24700147

ChemSpider ID: 24700147

PubChem CID: 24771867

Chemical formula: C27H20ClFN4O4

[intlstar1 in reply to Godbeforme]

I had read that too when I was doing research on Alisertib.

[Francesca10]

Dear intistar

I think you should do the clinical trial. As others have said, it will be paid for and then disability will come through lessening the financial burden. I know how overwhelming this gets. I am paying $700 a month for insurance but it’s cobra and I am still working. There are so many treatment options now. Can you speak openly with your oncologist? And ask why he suggested this route? I am saying this because of the assumption it’s a last resort and it’s probably not. 🙏🏻🙏🏻🙏🏻 And hugs being sent to you.

Frances