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Changed from Ibrance to Afinitor

Not the results we wanted from my first pet scan last week since my diagnosis of MBC in September. After only three months on Ibrance, all of the spots had decreased in size or remained stable EXCEPT for the liver. There were 2 new small spots on the liver, and my oncologist said we had to change medications to try a new route. Now I am on Afinitor and Aromasin. I was doing so good on Ibrance, I really hated to start a whole new drug path after only 3 months. Has anyone had a similar situation?

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I was diagnosed in Feb 17 with MBC 6 lesions on my Liver and 2 in my spine. My first oncologist was very aggressive and I had 4 cycles of Dose Dense Chemo every 2 weeks for 4 rounds (Adriamycin/Cytoxan) then the plan was 4 cycles of Taxol. Prior to the Taxol I changed treatment plans with a new oncologist (mayo). I have just finished by 8th cycle of Ibrance/letrozole. I have been NED since Aug. I wish I knew which of the treatment plans go me to NED or if it was combo. There so many treatment plans and one size doesn't fit all. But, I am a fan of getting a second opinion.

You are in my prayers.

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I am getting a second opinion in two weeks. I just need someone to tell me I am on the right path for the best treatment plan for me.

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That is a pretty heavy lift...something all of us sisters want. I had two oncologists giving me their best advice. It was a fork in the road, I had to make the choice. Everyday, I pray it was the correct path. You are in my prayers.

Lisa

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Yes it is a tough road to walk no matter how you are doing. I have found comfort in meditation and Buddhist readings. Very calming. I see Therapists and get inspiration from Kris’s Carr. She has a rare stage 4 liver cancer and has made lemonade out of that big lemon. I’ve needed a lot of help to get my head right and it is a work in progress. Love this board and my sisters on it. Happy Holidays and health and peace to us all.

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Super glad you got the new doc. That first round of treatment sounds like what I had back in 1999 when I had stage 2B and a mastectomy. 19 months of Ibrance/Letrozole and going strong

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I took ibrance for 3 months only and pet scan showed not working so started Afinitor with exemestane. Has only been a week. This is actually my fourth treatment. I have bc spread to bones. I was in remission for 5 years then came back to the bones. Just arrived to nyc Sloan Kettering for second opinion. So let’s see . praying

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Hello Westray! I am wondering how you did at Sloan. Did they give you any answers you didn't already know? Ibrance doesn't seem to be working on me either. I am going for a scan in 10 days to see if my tumors have enlarged. I have also been referred to Johns Hopkins to see what they would say about my case. I hope that you are doing well! I'm in the same boat as you are - spread to bones, but also to the liver.

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How are you doing now, jstickrod? I hope you are feeling better and have found a treatment that works. I am not doing well on Ibrance/faslodex combination right now. I have a scan soon to tell us more.

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When I went for a second opinion, I changed to the new oncologist, and he put me back on Ibrance/Faslodex regime, so was only on Afinitor/Aromasin for one month. I am in month 7 now of Ibrance/Faslodex. I still feel fine, but my tumor markers are slightly rising each month. He says we will know if/when the Ibrance has stopped working, and will switch me to a new treatment. We have not done any scans. He is not a big believer in scans unless necessary. I really hate to go off Ibrance since I have tolerated it so well. No side effects to speak of.....What problems are you having on Ibrance/Faslodex?

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My only problem is my markers going up. I feel pretty good - just knee and bone pain. It is good to know that your doc still has you on the meds even though your numbers are going up. My doc told me that it is more important that my liver function is good than the marker number. I'm glad that you have no side effects.

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It sounds like our Drs are similar in opinions. My tumor markers are continuing to rise, and he said we would keep a close eye on that, but my liver function results are normal. I'm scared Ibrance is not working, and we will have to change meds. Does anyone have a similar situation, and what meds did they change you to?

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