Magnesium and heat and Pregabalin

[wantokporo]

From my research it seems that Magnesium Oxybate is the interaction problem, and I am supposing not other forms of magnesium?

Second query: I have stored some Pregabalin in my car glove compartment for emergencies and now have to take them waiting for a renewal and I am wondering if heat can affect its efficacy?

Thanks in advance!!

[Hidden]

Hi, apologies. I'm not clear what you're asking about magnesium.

Any drug will be prone to undergoing changes due to heat.

Some actually come along with advice on what range of temperatures to store them in. "Room temperature" is advised for pregabalin. It just depends what you count that as. 25C is mentioned.

The other factor is humidity.

I wouldn't imagine a glove compartment is suitable even without global warming either heat wise or humidity wise.

[wantokporo in reply to Hidden]

Sorry about that: on a recent thread it was mentioned that magnesium interacts with pregabalin. Since I take a lot of magnesium threonate nightly, I looked into it. I found that the magnesium that interacts with it is magnesium oxybate.

Well, I will be doing the test with the (possibly spoiled from heat) pregabalin since they wouldn't refill my prescription...

[Hidden in reply to wantokporo]

I believe it's the magnesium itself that's the issue. It decreases stomach acid.

Whereas that's good for the absoprtion of some things, it's not good for others.

E.g. iron is better absorbed if stomach acidity isn't too low.

Antacids can prevent the absorption of some things including iron.

Magnesium is the basis of some antacids

[wantokporo in reply to Hidden]

Thanks.

[Yellowcake]

All medications that I know of (that don't have to be refrigerated) should be kept between 68-77°F. Anywhere in a car is not a good place to keep medications. Heat will reduce efficacy but shouldn't make them totally useless.

[wantokporo in reply to Yellowcake]

Another question then: where do people leave extra emergency medications in case of an emergency and you can't access your house and pharmacies are swamped, etc?

And second comment: maybe then taking my magnesium at another time + my heated up pregabalin will balance each other out 😀.

But while I'm on the magnesium, I should take it two hours before the pregabalin?

[Madlegs1 in reply to wantokporo]

Magnesium in any form will hinder the uptake of Gabapentin ( NOT Pregabalin). Take three hours apart.

I may have mistakenly included Pregabalin in the same breath as Gabapentin, but rectified that misinformation at the time.

There is quite a debate on the best form of magnesium and it also depends on what you need it to do.

Generally, any of the mg ---ates are better.

Regarding storage, I wonder if a small stainless steel thermos container, with some of those dessicant sachets, would keep pills dry and cool??😎

Just a thought?

Good luck.

[LanaCSR in reply to Madlegs1]

Hey Madlegs1 I was reading your reply to wantokporo about the type of magnesium to take. My bottle of magnesium says magnesium oxide. Do you think I should try a different kind? If so, what would you recommend? And how much do you take? I've been taking 500 mg once a day. Also, I have been taking it with supper along with my Horizant (a form of gabapentin). But you are saying it may adversely affect gabapentin?

[Madlegs1]

It will definitely hinder the absorption of the Horizant. 500 is quite a hefty dose-- useful laxative!I use mg citrate 100mg, in the afternoon or evening ,just to help calm nerves and muscles.I Don't take it everyday, more whenever I think about it!( But I'm on opioids, so don't really worry about " real" rls.)

Mg oxide is the cheapest form of mg. If it works for you ,then ok!!👍

Good luck.

[LanaCSR in reply to Madlegs1]

Thank you, Madlegs1! I really appreciate your input!!

P.S. I went on Amazon to buy a bottle of magnesium citrate 100 milligrams, and someone actually left a review saying how it has helped her RLS!!!! So that's the one I ordered...lol. My only concern is that the instructions say to take it 3 times a day preferably with meals, but I saw multiple reviews by people who said it helped them go to sleep. I suffer with profound daytime sleepiness and don't want to take something that will make the sleepiness worse, but at the same time I know I need to take magnesium for my RLS. Am I worrying too much about this? I welcome any advice anybody can offer. Thanks guys!! 😊

[Madlegs1 in reply to LanaCSR]

Yes-- you worry much too much. Use magnesium for your own purposes, not what the manufacturer wants you to do.You are in charge of your health management.

You want the mg for help to relax before bed-- then that's the time to take it. Try 100 at first,- see how that goes for a few nights. Then up it if necessary. Play around. It's highly unlikely to kill you.😎

( Mg doesn't make you sleep ,as a sleeping pill does, rather it relaxes your body)

Good luck.

[SueJohnson]

Keep the emergency supply in your purse.

[WideBody in reply to SueJohnson]

I should keep mine in my wife’s purse. It always becomes a topic of conversation on late night drives home.

[wantokporo]

Perfect! Thanks!