Hi All-
I am a long-time RLS sufferer but this is my first post. I am a generally healthy 38 year old male but I suffer from excruciating RLS every night and am currently controlling the symptoms with 600mg gabapentin plus 600mg horizant. I’ve stayed away from DA due to fear of augmentation. Without medication the RLS symptoms and sleep issues are unbearable. For a variety of reasons I would like to find a better long-term solution then gabapentin.
I had an idea I thought might be interesting and just wanted to throw it out for consideration. It was triggered by my experience with magnesium. I’ve experimented on myself over the past few years with various forms of magnesium (malate, bisglycinate, citrate, etc.) in the hope that this could help treat the symptoms. What I found was although these were effective for boosting serum magnesium levels (i.e. magnesium in the body) they had no neurological effects (likely because my body was not low in magnesium in the first place). However, when I experimented with magnesium l-threonate (2000mg which equates to only 144mg of elemental magnesium, a relatively small amount) the neurological effects were significant. I believe this is because the magnesium / threonic acid chelation crosses the blood brain barrier more efficiently and therefore boosts brain magnesium. Basically magnesium l-threonate functions as a mild NMDA antagonist / glutamate blocker for me. The first time I tried it, during the afternoon, I would almost describe the effect as slightly dissociative. Taken at night, magnesium l-threonate provided some mild RLS relief (I’m guessing for the same reason that other glutamate blockers like gabapentin help). I began taking it nightly, and I found that over time my body seemed to adjust to it, and it no longer provided much relief. When I stopped taking it after approximately 6 months, I suffered from significant rebound anxiety for about a week. I would caution others to be careful in experimenting with magnesium l-threonate as the neurological effects are quite powerful and I’m not sure how fully understood they are.
The takeaway here for me was that while I don’t think magnesium l-threonate is a great long-term treatment for RLS, I do believe that the chelation of a mineral (in this case magnesium) with threonic acid significantly changes the way the body metabolizes it and allows it to more efficiently cross the blood / brain barrier. And so my thought is: would it be possible to do the same with iron (chelate it with threonic acid)? I noticed from googling that this possibility is mentioned in one of the patents for magnesium l-threonate.