My next attempt at relief is to try L Tyrosine is a non essential amino acid that is the precursor of the neurotransmitter, dopamine. Tyrosine is converted into Levodihydrophenylalanine (L-Dopa) and L-Dopa is subsequently and avidly converted into dopamine. More on the subject here:clinicaltrials.gov/ct2/show...
L Tyrosine may be helpful: My next... - Restless Legs Syn...
L Tyrosine may be helpful
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BoldMove
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Tried it myself, didn't help.
Since tyrosine hydroxylase tends to be increased in RLS cases, I've taken it to mean that in my case at least, any deficiency in dopamine is an iron problem.
Also dopamine levels are generally found to be normal with RLS. I don't think it's known whether this could be a result of some sort of feedback which limits the transmission of dopamine across the synapse when the supply of dopamine is low, or whether it's because, given a problem with postsynaptic receptors, presynaptic dopamine homeostasis is otherwise maintained.
In cases where dopamine agonists work, I think the pointer is towards the latter.
Thank you Ironbrain. I'm becoming increasingly hesitant and may just stay with iron, B12, B50, and trying to remain stress free - (not an easy feat).
in reply to BoldMove
ironbrain has a good point. Since I'm new to this 'wonderful' disease I'm willing to consider anything and everything. You did mention that word 'STRESS' I am such a Type A person, if anyone gets a handle on reducing stress, bottle it and I'll pay anything. At 73 I'm probably going to take stress to my grave. It drives me crazy when people try to be helpful with advice like'Just don't worry'etc. If it was that easy to control stress, I would have done it by now!(LOL-but not really.)
Let us know how you get on.
I looked into it for helping with the wirhdrawals- but decided against it-- Too many side effects.
Good luck.
I also have my concerns and it may take awhile before I try. Remembering to take it 30 minutes before a meal rather than whenever is also holding me back.
in reply to BoldMove
Hi BoldMove. I have several meds to take at odd times. This works for me. Since I almost always have my cell phon with me I set alarms(using different ringtones than for phone calls). Then I have pills in my purse. This helps me not miss doses. Just a thought.
BoldMove in reply to
thank u. I am not taking any of these meds. I am only trying natural means. So far, trying to have the computer off early in the day, and avoiding sources of stress, plus waking 30 min a day have been my greatest relief
in reply to BoldMove
Hi Boldmove,
How's the blue light filter working out? Do you notice a difference?
BoldMove in reply to
I feel more relaxed when I go to sleep, less vicious RLS, but I am in Houston and the stress of all that is going on here has ratcheted up the pain level. It will take more time to be sure, regardless, I like the softer light at sundown and thank you so much for finding this way of turning down the glare. It's appreciated.
Back to the cleanup from the storm of the century "Horrible Harvey"
in reply to BoldMove
I'm glad it's working for you.
Oh, I'm so sorry! I have 2 brothers in west Houston and near The Heights. The one in west Houston left before it hit for the sake of their 2 young boys. The other is riding it out (and was doing fine yesterday). I'll check in with him today, especially since things are moving rather quickly re evacuations. He sent me a picture of Addicks and wow! I hope you are holding up okay. Will be thinking about you.
BoldMove in reply to
Many thanks. Our subdivision is in a high spot. We were so lucky, but everything around us is devastated. Glad your other brother got out
I also tried L-Tyrosine and found it made absolutely no difference - sadly. It had that in common with L-Theanine, Magnesium, Taurine, Phosphatydil serene, Macuna pruriens, passiflora tincture etc etc etc Oh and also soap in the bed - that didn't work either.
Raising iron levels was the only non-pharmaceutical intervention to help me.
Thank you so much. I also tried L-Theanine and it appeared to help for a few weeks, then it just stopped working. I take Magnesium citrate regardless, but that does not seem to help, iron is also something I take. Soap in bed was just annoying.
So far the only thing consistent is 0 access to a computer - no RLS that night. But, I can't spend my life on vacation and I must live in the real world.
Thanks again.
I was just on a 7 day vacation and was RLS free for maybe 5 of those nights. At home I have pretty symptoms nightly (I had a Magnesium supplement respite for a couple months which appears to be past waning...so sad to report). I was reviewing all of the variables on vacation that could have contributed to being RLS free for much of it...I would guess maybe a lighter stress load, but I am curious if being screen free was of help?
Screen free has been my only opportunity for a good night sleep. But, I can't live life on vacation even if I'd like to.
in reply to BoldMove
I'm assuming by your post that you work with computers? Blue light affects the brain by making it believe it's light out and therefore time to get up.
I'm wondering if turning down the screen light would help you? Or, maybe there's a way to change the RGB settings.
in reply to BoldMove
Yesterday I bought a new computer..Had given mine to family member so using one in the senior living library so no access overnight. Last night very tempting to read and reply to posts but resisted til now 5:30 am when I got up to take med. Slept pretty well. Am going to try to stay off at night but still pretty tempting. Maybe it wakes my brain up and then my nervous System wakes up too. Sounds logical but IDon' t know Going back to bed. Early morn sleep after being up a short time is the best for me. Don't know why. Later, everyone. It's almost 6am. Goodnight. Butma
in reply to JumpinBean
Re: soap in bed: I agree but have to admire ingenuity. I recently saw an ad in one of my catalogs for thinly sliced soapbars for rls-not so bulky! You have to admire someone finds away to make money off this. They were expensive.Can you imagine!
it's interesting to hear that being on vacation dimishes the RLS for you. It normally does for me too. Do you think that it could be because it's exciting, stress-free, and there are things to keep us busy (other than work)? If only we could make daily life seem like a vacation...
BoldMove in reply to
I think it is the blue screen. I think there is a neurological disturbance created from the internet. I've had some stress free weekends, relaxing with friends, but using the internet and had RLS on and off all night.
I am going to try to not use the web for several hours prior to sleep - just don't know how to make that happen, and see if that helps.
in reply to BoldMove
How funny! I just finished my reply about blue screens, then saw this!
BoldMove in reply to
Great minds! I've tried amber safety glasses to wear from sundown till bedtime. They drove me crazy. It may be more than the light, it may be a combination of stimuli from computer use.
I would like to cut way back on computer use and try having it off for about 9 hours before bed, but I don't think that will ever happen.
in reply to BoldMove
Hear you there! There are so many things I know I need to cut back on but just can't. Is there a way to change the RGB settings? I honestly don't know the answer to that, so I'm asking. I'll experiment with it myself. Would you like me to let you know if I find out?
Hi, this is probably late but i read about going on holiday kills RLS for you. That's probably something to do with the magnesium in the sea i'd say.
This post is 3 months old though you're probably over it now hahah.
I take Mag citrate daily. It doesn't matter where I go for vacation, each time I leave for a couple of days I have little to no RLS.
Mine is neurological and is the neurological component that accompanies latent celiac disease. I still try to find help though. drugs don't work for me for more than a few days, then augments. I stay away from them.
Dell PC running Windows 10. Have a flat screen monitor.
in reply to BoldMove
Ok. Try this youtube video for for filtering blue light in Windows 10:
If that doesn't work, f.lux is a downloadable program designed to filter out blue light. It says it's free for ipad on iphone, but it doesn't mention desktops. I'm sure there are free ones for desktops as well, though.
Good luck,
BoldMove in reply to
Thank you! I got it set up (with help) to start tonight. I also intend to try a Walgreen's Restless Leg product several people have rated highly on this forum.
Yesterday, was a "vacation day" with very little computer time, and I had lest RLS activity and did not walk much or need ice sheets. Must be a multi pronged approach for many of us embracing a modern lifestyle.
Thanks again.
in reply to BoldMove
Yeah, it must be.
That Walgreen's cream doesn't happen to be Restless Leg Cream from Magnilife, does it? If so, I think you'll like it. I stock up on it every time I travel back to the States (I'm from Texas, but live in Norway).
Take care,
marsha2306 in reply to
I tried that same cream many times and it did nothing for me.
Thank you, but not a cream. I want to try Hyland's Restful legs dissolving tabs
in reply to BoldMove
Power to you for trying things! I really hope it works for you!
Helped me.
You suggested tyrosine. Why?
I read it raises dopamine levels, but has some side effects. Still debating over safety issues.
I'm in TX so if u respond to this, I may not answer for a week, I keep hoping I don't flood and power stays on.
The gabapentin works fine for me so no need for anything else.
I have a friend in Houston who just told me the water is covering the street and the sidewalks. She still has power.Where are you in Texas?
Also in Houston. Still have power. going to cook lunch. we've not had much time to eat. Continually working to keep water out of our house.
in reply to BoldMove
Just to say, how awful the hurricane has been over there. Hope you keep power AND keep the water out, it does seem to be getting worse from looking at our news here in the UK. Stay safe.
BoldMove in reply to
thank you, so far so good, taking it an hour at a time.
Sorry you've got all that to deal with.
So far home not flooded. So sad though seeing all the devastation.
BoldMove in reply to
It's the I want to try Hyland's Restful legs dissolving tabs that I've heard praised on this site. Worth a try. I'll also make a note of the cream u recommend, though another responder said it didn't work for her.
I'm in Texas too, originally from NY.
in reply to BoldMove
I'm originally from Houston, but now live in Norway.
The Hyland Restlful Leg product at Walgreens works really really well for me. I ordered it from Amazon and it was a little cheaper.
Yes, that is what I plan to buy at Walgreens. I'm glad to know it works for you, I hope it works form me.
Just FYI though, remember that I take gabapentin also (a pretty low dose) and use the dissolving tablets if/when the gabapentin wears off and my legs start jumping at bedtime. I also have RLS in my hands and the dissolving tabs stop that immediately and I fall right to sleep in minutes every time I take them.
OK, thanks. will keep in mind
Have you tried GABA, the amino acid? GABA CALM is a great product.
No, but I will put it on my list to order. I'm sure my problem is neurological. I have latent Celiac disease, diagnosed in 2009. It came with gallbladder removal surgery. Had all the signs from the moment I woke up the next day and was diagnosed a few months later. Latent CD has a neurological component. In 2010 I had the most mild signs that were mild disturbances, didn't last long, and not much of a bother. I would take iron at night and they were under control for awhile.
RLS gradually became more intense. I ran my symptoms by my GP who confirmed it. He gave me Mirapex which worked for 6 days, then not at all. I decided to try naturals.
Celiacs don't absorb meds or much else like normal people's guts, so all is problematic. But, everything is worth a shot. I have at least one decent night a week. I try to allow 10 hours for "sleep" in order to get between 5 and 6. During the walking time, I do little chores that I had let slide to gain those extra "sleep" hours. I may be a lost cause on this forum.
Sorry for the ramble.... which I usually don't have much time for.
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