The next to the last paragraph is probably most pertinent to us. I'm sure it hasn't been tested on people with PMR yet but perhaps with other AI disorders or on immunosuppressant medications.
This is an article from last November that talks more about people in immunosuppressed states. nytimes.com/2017/11/10/heal...
This article out of Canada has more details comparing people who took Shingrix vs Placebo under the Clinical Trials section.
I found the discussion of adverse events most germaine.
Potential Immune-Mediated DiseasesIn studies ZOE-50 and ZOE-70, new onset of potential immune-mediated diseases (pIMDs) or exacerbation of existing pIMDs were reported for 1.2% of subjects who received SHINGRIX and 1.4% of subjects who received placebo during the entire follow-up period (median 4.4 years, range: 0 to 5.0 years). Approximately half of pIMDs occurred with time to onset longer than one year after the last vaccination. The most frequently reported pIMDs in the vaccine and placebo groups were polymyalgia rheumatica (0.2% in each group), rheumatoid arthritis (0.1% versus 0.2%, respectively), psoriasis (0.1% in each group), and autoimmune thyroiditis (0.1% in each group).
I think it is worthwhile discussing with my Rheumy. I had chicken pox at 18 months, and Herpes Zoster at age 22 in my middle ear. So I know it is lurking.....I had the older vaccine when it came out, but I suspect I'm susceptible. Not sure I want to rock the PMR boat right now, but if I read this correctly, there was no difference between Shingrix and Placebo groups over the four years tested.
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I’d be more reassured if I knew the placebo group just had something like saline instead of the carrier, with all the adjuvants etc, minus the virus. It may be the constituents of the vaccine other than the virus that stimulate an immune response that, in some, cause an overreaction.
Yes, should be but when I was researching vaccines for my kids, some vaccine data hadn’t be done like that. Also, another thing I found was short periods for collecting the data.
If its live...........................I would not touch it.
I had had shingles and then when it raised its ugly head again, the GP moved fast and I got the 'stuff' (cannot remember the name) which stopped it in its tracks. The 'stuff' has to be given within a 24 hours window from the first signs.
It's not live. And it's supposed to be much more effective in the older population than Zostavax. My husband had it last week and was knocked flat with flulike symptoms for most of a day. He had a large very red patch at vaccination site, which subsided to a bruiselike appearance after another couple of days. I wouldn't let him have Zostavax as I haven't had CP and didn't want to risk exposure to the live virus.
I think the ‘stuff’ is Acyclovir. I had it too as soon as the rash appeared. It stopped more blisters appearing but I was still poorly and had nerve pain for a few weeks.
Thank you it is the name of the 'stuff'. I am sorry to hear you still had pain and were poorly for a few weeks, a couple of days and I was fine. Guess I was lucky that day.
Still I feel conflicted about whether to have or not to have - even the non-live vaccine Shingrix !!!??? ---- I'll be interested to read the responses and consensus here and any reported experiences ...
I did not have this vaccine,l know someone who became very ill after it. I am sure that it may be perfectly OK for a lot of people but the side effects can be a problem and having PMR could make it more risky. I had chicken pox as a child and also had shingles a few years ago,although it was only a small area that was affected.
I had the shingles jab,the two months later had shingles, was very painful for about. 4 weeks, then faded out, I haven't had the pain afterwards, as some people have after shingles, so maybe the vaxination was the reason it wasn't so severe
Which vaccination did you have? Zostavax (live vaccine, fairly ineffective for older patients) or Shingrix (killed virus something like 90% effective in people over 50)?
Just got the first dose last week. Be sure you are not doing anything for 3 days after getting the shot. Very sore arm for about four days and felt under the weather for a couple of days.
It is claimed that it reduces the risk of developing shingles and, if you do develop shingles, reduces the risk of post-herpetic neuraligia which is probbaly the worse part of shingles.
If you weren't required to have a second shot it will have been Zostavax as the Shingrix requires two doses, the second within 2 to 6 months after the first.
Ha, guess I should have read further up thread. Start my day by checking my notifications.... I wonder if the second shot is typically better or worse for reaction than the first. If worse I think hubby will need to plan his schedule carefully.
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