Pelvic Pain Support Network
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Hi all , been a while since I posted does anyone take duloxetine for pudendal nerve pain ?? I have been going round and round the mulberry bush for nearly 6 years , been told various diagnosis , one so called rectal specialist said a chronic fissure, paid private to see a different rectal specialist who Did me a exam under a general aenethetic who diagnosed that there was no fissure higher up inside me two weeks before I was told there was , so I feel like I am just getting fobbed off

I do have fibromyalgia and have had it for 16 years and have read that duloxetine is good for fibro but is also a good nerve pain drug , when I can actually get a appointment with my regular g.p I want to ask to try this , as I need something for the pain as I am permanently climbing the walls with the pain

I am unfortunately drug sensitive , but think this may be a possibility, any ideas??!

9 Replies

I took duloxetine for a few months. It did help with the pain, but I had to stop taking it due to horrible nightmares. I'm not sure if this is a listed side effect or just me. It is not a drug you can stop taking instantly either, I had to reduce gradually. I hope this helps. I wish I could have stayed on it because it did reduce pain slightly.


Hi, I am in the same situation now five years.I think first and for most we have to get a

definite diagnosis, which is unbelievably hard to get. According to pudendal hope web site and health organisation web site - pudendal nerve entrapment should be diagnosed by MR Neurography and requires surgery. Pudendal neuralgia can be treated by pain management injections. It would be advisable to go to a pain management specialist who is experienced at treating the pudendal nerve. My symptoms are of pudendal nerve entrapment but causes my right hip to be unstable and irritation of the sciatic nerve as well. All I can suggest is go back to your GP and discuss both rectal specialists findings and ask him/her to help you get the diagnosis of a possible rectal fissure checked by ultrasound which your GP can request. Also a referral to a neurologist for MR Neurography to check the pelvic nerves, especially the pudendal nerves. Please keep in touch and let us know how you get on. This may take time so don't let neurologists fob you off without MR Neurograhy as you need a definite diagnosis so that you can get on the right track for treatment. Good Luck and let us know how you get on.

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My doctor tried me on duloxetine for my neuropathic pain, which may be PN, replacing amitriptyline(as the drugs clash). He also thought it might help with my depression & chronic low back pain.

It was nowhere near as effective for the neuralgia as the cheap and cheerful amitriptyline , but did lift my mood a bit.

The pain became unbearable so i switched back after trying the dulox for about 6 months.


I tried Duloxetine after going through most of the other drugs usually prescribed , including opiates, lyrica , amitriptiline ect. Duloxetine made me nauseous and I completely lost my appetite while taking it . It had an adverse psychological effect too.

I've read it can be very hard to stop because of severe withdrawal symptoms too. You may react differently to it and it may be worth a try, but I wouldn't expect too much in order to avoid disappointment.


Hi Folks. I have suffered for 15 years. I have had 7 nerve blocks and 2 operations last one Nov last year. Still in pain and my only relief comes from taking Pregabalin (Lyrica).


I heard Lyrica is expensive. Could you function well while taking it. I am currently taking Gabapentin and it makes me drowsy plus I have a metallic taste in mouth. Rocky68


I was taking 3600mg of Gabapentin to begin with and I was like a Zombie. Pregabalin works really well and when It wears off I do not get bad depression like I did with Gabapentin. Pregabalin makes me feel a little high but I can function normally.


There is an interventional radiologist in Atlanta, Georgia at Emory St. Joseph's Hospital who is curing PN through image-guided cryoablation. I know that's probably too far for many of you to travel, but if you've suffered for years with the pain it might be the relief you're looking for. 90% of PN patients treated by Dr. Prologo are pain free and it's a minimally invasive procedure; you're in and out in one day. I'm a journalist who just did a story with him and he is very passionate about what he does. Through image guiding he's able to locate the pudendal nerve and insert a tiny needle to freeze it. Freezing it and thawing it shuts down the nerve so it stops firing off pain signals. No big side-effects, just some soreness. Here's the study:

He uses the same technique to cure phantom limb pain in amputees.


n = 8. Is there more data on his outcomes?


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