My journey began about 6 months ago when after a 10 day course of Augmentin I noticed that my urine was a bright orange and I was itching all over my body. I also had incredibly bad indigestion along with constipation. This lasted about a week and I went in to see my physician. The labs came back with high LFT's and a billirubin of 4.0. They did an ultrasound and found no stones or billiary blockage. My labs were repeated in a week and my billirubin was back to normal and my LFT's were coming down. Within a few weeks all of my LFT's were normal except the alk phos. At this point he felt that my liver responded adversely to the Augmentin. I then saw a gastroenterologist who did an extensive blood workup. Everything was normal except for the AMA titer which was 1:160 and my alk phos was mildly elevated. All signs pointing to PBC. Last week I had a liver biopsy and today my doctor and I viewed the findings. They came back inconclusive with only a few lymphocytes seen in the bile ducts along with mild hepatitis. So now my doctor is going to call the pathologist and if he does not agree with the PBC then the liver biopsy will go to a hepatologist at The Mayo Clinic here in Phoenix. I am going to start on Urso after my doctor speaks with the pathologist just to get me going. If I do have PBC I suppose I am in the very early portion of stage 1, but time will tell. At this time I have no symptoms to speak of and I feel great. I continue to assume I have PBC because I have not heard of anyone having a positive AMA titer along with elevated alk phos and not having PBC. I will write in a couple weeks and give an update. Nice to meet you all. Bob
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