Ever since I was diagnosed with PBC last year I've been anxious everytime I have my labs drawn. I'm always anxious to know all about what my Liver Function Tests (LFT's) numbers are and if they're rising.
When I joined this group many were concerned about elevated AST, ALT, and Alk-phos etc. So I became the same. And over this past year my Alk-phos has fluctuated. This last lab draw it was slowly climbing. 😔
Over the past year in all my research about PBC I've come across lots of good information. The informative posts on this site are of vital importance too and so many of us appreciate them. ❤
I often copy and keep posts to re-read over again or to share with my doctors. This is what I was doing when I came across a post (sorry I didn't copy who posted it😕) that I had read earlier several months ago and that only now has really sunk in. (Brain fog??)
It had to do with those LFT's that I've become so consumed with watching. And to be fair, they do serve their purpose giving our doctors rounded out information. However, this post stated that those LFT's were not a prediction of PBC progression. It stated that even ones in later stages of PBC could have normal or close to normal AST, ALT, and Alk-phos.
It said that liver enzymes were NOT liver function tests. Somewhere over this past year I confused the two. I even perpetuated the belief by my own posts that Liver enzymes and LFT's were the same thing. Even now I can't get it out of my head that my Alk-phos isn't something that I need to watch like a hawk. It's hard to un-learn.
The post stated that the best biochemical tests for liver "function" are ...*serum albumin concentration, *serum bilirubin, and *prothrombin time (that last one I've never seen on my labs).
It concluded by stating that the *serum bilirubin concentration (which may also be lowered by Ursodiol, yay!) is probably the "best" biochemical predictor of PBC disease progression. It also included this link.
The poster concluded with her own personal information which I found comforting and hope you do too. She said,
"I am Stage 4 with stable LFT's diagnosed 27 years ago."
So while I, ktltel - Stella, (out of habit) still check out my AST, ALT, and Alk-phos, I will now most importantly be watching my Albumin and bilirubin. ❤
Thank you to that poster!❤ I've been a little slow on the uptake.
**Revision: Please note that recent information stated that a rising Alk-phos does give indication of possible PBC progression. New and ongoing studies and trials are difficult to keep up with. If you are uncertain about the role a rising alkaline phosphatase can mean in your PBC case, please ask your doctor about current or new information.**