Hi, A year ago I had my first bout of very strange and severe anxiety and depression linked to perimenopause. I am 48. A blood test showed my oestrogen level had significantly dropped. After a couple of months I seemed to re-stabilise and didn’t need HRT. I had been taking a supplement, recommended by both the GP I saw at the time and my naturopath, that increases oestrogen receptors that initially seemed helpful. Then I read about problems with oestrogen receptors in PBC that sounded like it might be wise to stop the supplement (Metagenics O-Lift), so I did. Around this time I’d improved anyway.
Now I’m back in a severe depression and anxiety which I can feel is hormonal. I’ve booked a counselling appointment through the Australian menopause society who provide support and advice. However, I doubt they will know much about PBC. I’ve found GPs do not know about it either.
I’ve read from others here about the recommendation of hormonal patches rather than oral medications if you have PBC. I’m wondering what has been the best treatment others have found that also seems to be compatible with PBC? While reduced sleep is an issue, extremely low mood over the past few weeks has been the most extreme symptom.
Thank you in advance for any input/advice. I’ll see if the PBC Foundation have info too.