Hi I was diagnosed with PBC six months ago I had been unwell for months but I also suffer from Ulcerative Colitis and Entropathic Arthritis for 10 years. I haven't found the right treatment for my UC as I have had reactions to basically all meds I've been put on. I'm starting a new drug vedaluzimab so I am hoping to get some relief. My Drs haven't given me Urso for my PBC they are treating the itch, but I'm concerned, I want to do all I can to slow down progression. I have had such a hard time I have lost faith in my Drs. Is there a stage on which you should start Urso? I suffer from itching and chronic fatigue which I can't cope with! I'm exhausted constantly. I think I should be put on Urso I just don't know why I'm not.